Person: YILDIZ, PELİN
Current Approach to the Prognostic Parameters of Testicular Germ Cell tumors Accompanied by Our Cases
2020-08-01T00:00:00Z, Çoban, Ganime, Yıldız, Pelin, Sezal, Zeynep, Adıllı, Adile, Beşiroğlu, Mehmet, Akçay, Muzaffer, Gücin, Zühal, ÇOBAN, GANİME, YILDIZ, PELİN, BEŞİROĞLU, MEHMET, AKÇAY, MUZAFFER, GÜCİN, ZÜHAL
N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions.
2018-11-01T00:00:00Z, Ceylan, B, Ozansoy, M, Kılıç, Ü, Yozgat, Y, Ercan, Ç, Yıldız, PELİN, Aslan, T, YILDIZ, PELİN
Objective: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity. Methods: Twenty-eight Wistar rats were divided into four groups comprised of control, colistin, NAC, and colistin–NAC co-treatment, respectively. Serum creatinine and urine N-acetyl-b-D-glucosaminidase (NAG) levels were measured at different time intervals. Histological changes, apoptosis, total oxidant and antioxidant status, and the expression levels of endothelial nitric oxide synthase (eNOS), superoxide dismutase 2 (SOD2), and matrix metalloproteinase 3 (MMP3) were evaluated in renal tissue. Results: In the colistin group, post-treatment creatinine levels were higher than pretreatment levels (p ¼ .001). There was a significant increase in urine NAG level following colistin treatment on day 10, compared to the baseline value and the first day of treatment (p ¼ .001 and .0001, respectively). Urine NAG levels were higher in the colistin group on the 10th day of treatment than in the other groups (p < .01). Colistin treatment increased the apoptosis index and renal histological damage score (RHDS) significantly and these changes were reversed in NAC co-treatment (RHSD and apoptosis index were 45 and 0 for sterile saline group, 29 and 2 for NAC group, 122 and 7 for colistin group, and 66 and 2 for colistin þ NAC group). We observed no difference between groups regarding total antioxidant and total oxidant status in the kidneys. The expression levels of eNOS, SOD2, and MMP3 decreased significantly in the kidneys of colistin-treated rats; these changes were reversed in the kidneys of NAC co-treated rats. Conclusions: N-acetylcysteine prevented colistin-induced nephrotoxicity through activation of expression levels of SOD2, eNOS, and MMP3.
A Case of Multiple Familial Trichoepitelioma with Malignant Transformation Successfully Treated with Vismodegib.
2020-05-13T00:00:00Z, Cengiz, Fatma Pelin, Kelahmetoglu, Osman, Yildiz, P, Tekce, E, Akarslan, Tc, Shbair, A, Seker, M, Onsun, N, KELAHMETOĞLU, OSMAN, YILDIZ, PELİN, YENİGÜN, ALPER, TEKÇE, ERTUĞRUL
Effects of Orally Consumed <i>Rosa damascena</i> Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats.
2019-11-10T00:00:00Z, Demirbolat, İ, Ekinci, C, Nuhoğlu, F, Yıldız, PELİN, Geçer, MÖ, KARTAL, MURAT, YILDIZ, PELİN
Diabetes mellitus is a multisystemic metabolic disorder that may affect the eyes, kidneys, vessels, and heart. Chronic hyperglycemia causes non-enzymatic glycation of proteins and elevation of the polyol pathway resulting in oxidative stress that damages organs. The current study aimed to investigate the dose-dependent effects of orally consumed Rosa damascena Mill. hydrosol on hematology, clinical biochemistry, lens enzymatic activity, and lens pathology in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced into male Sprague-Dawley rats by intraperitoneal administration of STZ (40 mg/kg body weight). Rose hydrosols containing 1515 mg/L and 500 mg/L total volatiles (expressed as citronellol) were introduced to rats orally for 45 days. Consumption of 1515 mg/L volatile containing rose hydrosol successfully ameliorated hematologic, hepatic, and renal functions. Hydrosols also attenuated hyperglycemia and decreased the advanced glycation end-product formation in a dose-dependent manner. Rose hydrosol components significantly increased the lens enzymatic activities of glutathione peroxidase and decreased the activity of aldose reductase to prevent cataractogenesis. Histopathological examinations of rat lenses also indicated that increasing the dose of rose hydrosol had a protective effect on lenses in diabetic conditions. Additionally, in silico modeling of aldose reductase inhibition with rose hydrosol volatiles was carried out for extrapolating the current study to humans. The present results suggest that rose hydrosol exerts significant protective properties in diabetes mellitus and has no toxic effect on all studied systems in healthy test groups.
Localized Darier-s Disease
2016-08-01, BAHALI, Anil G., Su, Ozlem, Biyik Ozkaya, DİLEK, Dizman, DİDEM, Yildiz, PELİN, Demirkesen, Cuyan, Onsun, NAHİDE, BAHALI, ANIL GÜLSEL, SU KÜÇÜK, ÖZLEM, BIYIK ÖZKAYA, DİLEK, DİZMAN, DİDEM, YILDIZ, PELİN, ONSUN, NAHIDE
Inverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern
2015-10-01, ÖZNUR, MELTEM, YILDIZ, PELİN, BAHADIR, BURAK, BEHZATOĞLU, KEMAL, YILDIZ, PELİN
High-grade prostatic intraepithelial neoplasia (HGPIN) is considered to be an important precursor for prostatic adenocarcinoma. The present study aimed to investigate the histological features of the uncommon inverted (hobnail) pattern of HGPIN in transrectal ultrasonographic (TRUS) prostatic needle biopsies from 13 cases. These 13 diagnosed cases of inverted HGPIN were identified out of a total of 2,034 TRUS biopsies (0.63%), obtained from patients suspected to have prostate cancer. The hobnail pattern is comprised of secretory cell nuclei, which are histologically localized at the luminal surface of the prostate gland, rather than the periphery, and exhibit reverse polarity. Histological examinations were performed and the results demonstrated that 5 of the 13 cases exhibited pure inverted histology, while HGPIN was observed to be histologically associated with other patterns in the remaining 8 patients. In addition, an association with adenocarcinoma was identified in 7 of the 13 cases. All 7 carcinomas accompanied by inverted HGPIN were conventional acinar adenocarcinoma cases; of note, for these 7 cases, the Gleason score was 7 for each. One acinar adenocarcinoma case accompanying inverted HGPIN demonstrated hobnail characteristics in large areas of the invasive component. It was observed that nuclei were proliferated in the invasive cribriform glands, which was comparable to that of inverted HGPIN, and were located on the cytoplasmic luminal surface; a similar morphology was also observed in individual glands. In conclusion, the results of the present study suggested that the hobnail HGPIN pattern may be of diagnostic importance due to its high association with adenocarcinoma and the high Gleason scores in the accompanying carcinomas.
Diffusion MRI on lymph node staging of gastric adenocarcinoma
2015-06-01, HASBAHCECI, Mustafa, Akcakaya, ADEM, Memmi, NAİM, TURKMEN, Ihsan, Cipe, Gokhan, Yildiz, PELİN, Arici, DİLEK SEMA, MUSLUMANOGLU, Mahmut, AKÇAKAYA, ADEM, MEMMİ, NAİM, YILDIZ, PELİN, ARICI, DILEK SEMA
Objective: The purpose of this study was to evaluate the accuracy of diffusion weighted magnetic resonance imaging (MRI) in preoperative assessment of metastatic lymph nodes of gastric cancer. Methods: A total of 23 gastric cancer patients with a mean age of 59.4±10.9 years were analyzed. Lymph nodes were grouped as perigastric lesser curvature (Group Ia), perigastric greater curvature (Group Ib), D1+/D2 lymph nodes (Group II). Identification of histologically metastatic lymph nodes by diffusion weighted MRI was regarded as the main outcome. Results: A total of 1,056 lymph nodes including 180 histologically proven metastatic lymph nodes were dissected. Although diffusion weighted MRI could identify the metastatic lymph nodes in 18 out of 23 patients (77.8%), only 69 of total 1,056 nodes (6.53%), either metastatic or non-metastatic, could be detected. There was no correlation between histopathology and diffusion weighted MRI with regard to lymph node groups (P>0.05 for all). Overall accuracy was calculated as 69.56, 65.21 and 52.17 for Groups II, Ib and Ia lymph nodes, respectively. Apparent diffusion coefficient (ADC) values could not be helpful to differentiate metastatic lymph nodes (P=0.673). Conclusions: Diffusion weighted MRI has low accuracy to detect or to differentiate metastatic and non-metastatic lymph nodes based on their ADC values in gastric cancer.