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YILDIZ, PELİN

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2013 - 20142
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Author: TOSUNER, ZEYNEP × Author: Tosuner, ZEYNEP × Has files: true × Type: Article ×

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Now showing 1 - 2 of 2
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    PublicationOpen Access
    Primary cutaneous carcinosarcoma: The first reported case with peripheral nerve sheath differentiation
    (2014-06-01T00:00:00Z) Yildiz, PELİN; Tosuner, ZEYNEP; Guneren, ETHEM; Demirkesen, Cuyan; YILDIZ, PELİN; TOSUNER, ZEYNEP; GÜNEREN, ETHEM
    Primary cutaneous carcinosarcomas (CS) are extremely rare biphasic tumors mainly located on sun-exposed areas of the body. Two hypotheses-multiclonal (convergence) and monoclonal (divergence)-have been suggested for the evolution of these tumors. According to multiclonal hypothesis two or more stem cells of epithelial and mesenchymal origin give rise to these tumors, while a single totipotential cell differentiate into epithelial and mesenchymal components, either synchronously or metachronously according to monoclonal hypothesis. Cutaneous CSs are subdivided into two distinct groups as epidermal and adnexal CSs, due to their epithelial content. We present an interesting case of cutaneous adnexal CS, showing peripheral nerve sheath differentiation and having the spiradenocarcinoma component derived from spiradenoma. To the best of our knowledge, it is the first reported case of CS with these features in the literature.
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    PublicationOpen Access
    Hamartoma of the breast in two patients: A case report
    (2013-08-01T00:00:00Z) Sonmez, FATMA CAVİDE; Gucin, ZÜHAL; Yildiz, PELİN; Tosuner, ZEYNEP; SÖNMEZ, FATMA CAVİDE; GÜCİN, ZÜHAL; YILDIZ, PELİN; TOSUNER, ZEYNEP
    Breast hamartomas are rare, benign, tumor-like nodules composed of glandular, adipose and fibrous tissue. The hamartoma was first described in 1971 as a lipofibroadenoma, fibroadenolipoma or adenolipoma, based on the predominant component of the breast tissue. Clinical findings resemble fibroadenoma and if there is a palpable mass, the patients may receive an immediate diagnosis. Ductal hyperplasia, apocrine metaplasia, calcification and adenosis may occur within the hamartoma, with rarer instances of lobular or ductal intraepithelial neoplasms. Although hamartoma is usually benign, a malignant transformation is possible. An excision and histological examination is necessary for the differential diagnosis and also for any epithelial lesions of the hamartoma. Simple excision is enough for treatment if there is no coincidental epithelial malignant lesion. The patients in the present study were treated by simple excision as there were no proliferative changes in the lesions. No recurrence or other problems were detected in the 18-month follow-up. The current study presents two cases of breast hamartoma that were diagnosed as an adenolipoma and a fibroadenolipoma, and then describes the macroscopic and microscopic observations of these lesions.