Person: EROL, EBRU
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Publication The Benefits of Plant Extracts for Human Health(2021-06-01T00:00:00Z) Erol, Ebru; EROL, EBRUThe genusBerberisincludes about 500 different species and commonly grown in Europe, the United States, South Asia, and some northern areas of Iran and Pakistan. Leaves and fruits can be prepared as food flavorings, juices, and teas. Phytochemical analysis of these species has reported alkaloids, tannins, phenolic compounds and oleanolic acid, among others. Moreover,p-cymene, limonene and ocimene as major compounds in essential oils were found by gas chromatography.Berberisis an important group of the plants having enormous potential in the food and pharmaceutical industry, since they possess several properties, including antioxidant, antimicrobial, anticancer activities. Here we would like to review the biological properties of the phytoconstituents of this genus. We emphasize the cultivation control in order to obtain the main bioactive compounds, the antioxidant and antimicrobial properties in order to apply them for food preservation and for treating several diseases, such as cancer, diabetes or Alzheimer. However, further study is needed to confirm the biological efficacy as well as, the toxicity.Publication Yeşil Alg Caulerpa cylindracea Sonder-den İzole Edilen Bis-İndol Alkaloidlerin SARS-CoV-2-ye Karşı in vitro Antiviral Aktivitesi(2022-06-23T00:00:00Z) Erol, Ebru; Avşar, Timuçin; Okudan, Emine Şükran; Topçu, Gülaçtı; EROL, EBRU; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTICaulerpaceae familyasına ait olanCaulerpa cylindraceaSonder yeşil bir deniz yosunudur. Gelibolu yarımadası kıyılarından SCUBA dalışlatoplananCaulerpacylindracea-nın builk kimyasal araştırması ile caulerpin1, mono metil caulerpinat2, beta-sitosterol ve palmitik asit izole edildi. İzole edilen bileşiklerin kimyasal yapıları, 1D- ve 2D-NMR ve kütle spektroskopik analizlerle aydınlatıldı. Caulerpin ve mono metil caulerpinatınin vitroanti-viral aktivitesi, Spike proteini ve main proteaza (3CL) karşı incelendi. Bu çalışmanın bulguları, caulerpin ve mono metil caulerpinatın Spike ve ACE2 etkileşimini önemli ölçüde inhibe ettiğini ortaya koymaktadır. Ayrıca, izole edilen bileşiklerin sitotoksik aktivitesi, sağlıklı fibroblast hücre hattı CCD-1079Sk ve iki meme kanseri hücre hattı; MDA-MB-231 ve MCF-7’ye karşı incelendi.Publication Antioxidant Activity of Polysaccharide Extract of Tricholoma imbricatum’’(2015-08-23T00:00:00Z) Kaplaner, Erhan; Erol, Ebru; Ozturk, Mehmet; Duru, Mehmet Emın; EROL, EBRUPublication Antioxidant Activity of Tricholoma focale mushroom(2015-08-23T00:00:00Z) Sıngec, Mehmet Huseyın; Kaplaner, Erhan; Erol, Ebru; Ozturk, Mehmet; Turkoglu, Azız; EROL, EBRUPublication The effect of cooking on the nutritional properties and the chemical composition of Armillaria mellea (Vahl: Fr.) Kumm(2012-10-01T00:00:00Z) Erol, Ebru; Çetintaş, Yunus; Ozturk, Mehmet; Duru, Mehmet Emın; EROL, EBRUPublication Di-, and Triterpenoids Isolation and LC-MS Analysis of Salvia marashica Extracts with Bioactivity Studies(2021-11-01T00:00:00Z) Toraman, Gulbahar O. Alim; Aydin, Sibel Kiran; Ertas, Abdulselam; Boga, Mehmet; EROL, EBRU; Saygi, Tuba Kusman; Halfon, Belkis; TOPÇU, GÜLAÇTI; EROL, EBRU; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIIn this study, dichloromethane, acetone, and methanol extracts of the aerial parts of the Salvia marashica plant which is an endemic species to Anatolia, were investigated. The total phenolic amounts of these extracts were determined as pyrocatechol equivalent and total flavonoids as quercetin equivalent. Antioxidant activity was determined by four complementary methods including inhibition of lipid peroxidation (by beta-carotene color expression), DPPH free radical scavenging activity, ABTS cation radical scavenging activity and CUPRAC methods. Anticholinesterase activity of the extracts was investigated by the Ellman method against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Viability and cytotoxic activity tests were carried out on the fibroblast L929 cells and cytotoxic A549 lung cancer cells, respectively. The triterpenoids and diterpenoids constitute the major secondary metabolites of the S. marashica acetone and methanol extracts isolated by chromatographic methods. Their structures were determined based on spectroscopic methods, namely NMR and mass analyses. Ten terpenoids were obtained from either acetone or methanol extracts of the S. marashica. Seven of them were triterpenoids, elucidated as lupeol, lupeol-3-acetate, lup-12, 20(29)-diene, lup-20(29)-ene, alpha-amyrin-tetracosanoate, oleanolic acid and ursolic acid besides a steroid beta-sitosterol. Two abietane diterpenes, abieta-8,11,13-triene (1) and 18-acetoxymethylene-abieta-8,11,13-triene (2), were obtained from the acetone extract which were isolated from a Salvia species for the first time in the present study. The methanol extract was found to be very rich in rosmarinic acid determined by LC-MS/MS analysis.Publication Determination of Antioxidant and Radical Removal Capacity, Total Phenolic and Flavonoid Content of Tricholoma terreum mushroom(2012-10-01T00:00:00Z) Ozturk, Mehmet; Tel Cayan, Gulsen; Cetıntas, Yunus; Erol, Ebru; Deveci, Ebru; Duru, Mehmet Emın; EROL, EBRUPublication Secondary Metabolites of Tricholoma caligatum (Viv.) Ricken(2018-04-09T00:00:00Z) Erol, Ebru; EROL, EBRUPublication Cytotoxic and antioxidant activity of Tricholoma caligatum (Viv.) Ricken(2015-08-01T00:00:00Z) EROL, EBRU; Ozturk, Mehmet; EROL, EBRUPublication Antioxidant, anticholinesterase and tyrosinase inhibition activities, and fatty acids of Crocus mathewii - A forgotten endemic angiosperm of Turkey(2016-09-01T00:00:00Z) Yildiztekin, Fatma; Nadeem, Said; Erol, EBRU; Yildiztekin, Mahmut; Tuna, Atilla L.; Ozturk, Mehmet; EROL, EBRUContext We report the first ever chemical/biochemical study on Crocus mathewii Kerndorff (Iridaceae) - a Turkish endemic angiosperm. This plant has never been explored for its phytochemistry and bioactivities.Objective This study explores C. mathewii corm and aerial parts for the chemical and biological properties of hexane, ethyl acetate, methanol and water fractions of the extracts.Material and methods Plant material (20g) was extracted by methanol (250mLx5, 3 days each) and fractioned into hexane, ethyl acetate, methanol and water. All fractions were subjected to -carotene-linoleic acid, DPPH, ABTS(+), CUPRAC, metal chelating and tyrosinase inhibition activities. Hexane fractions were submitted to GC-MS analysis.Results Ethyl acetate fractions showed excellent IC50 values in DPPH (aerial 36.210.76 and corm 33.87 +/- 0.02mg/L) and ABTS(+) (aerial 33.01 +/- 0.79 and bulb 27.87 +/- 0.33mg/L); higher than the IC50 of the standard -tocopherol (DPPH 116.25 +/- 1.97; ABTS 52.64 +/- 0.37mg/L), higher than BHA in DPPH (57.31 +/- 0.25mg/L), but slightly lower in ABTS (19.86 +/- 2.73mg/L). Methanol extract of aerial parts also showed higher activity than -tocopherol in DPPH (85.56 +/- 11.51mg/L) but slightly less (72.90 +/- 3.66mg/L) than both the standards in ABTS. Linoleic (aerial 53.9%, corm 43.9%) and palmitic (aerial 22.2%, corm 18%) were found as the major fatty acids.Discussion and conclusion Some fractions of C. mathewii showed higher antioxidant activities than the standards. There is a need to explore more about this plant.