Person: ÇAKIR, FATMA BETÜL
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Publication Metadata only Cross-sectional study: long term follow-up care for pediatric cancer survivors in a developing country, Turkey: current status, challenges, and future perspectives(2020-01-01T00:00:00Z) Incesoy Ozdemir, Sonay; TAÇYILDIZ, NURDAN; VARAN, ALİ; KEBUDİ, Rejin; ZÜLFİKAR, Osman Bülent; Celkan, Tiraje; Sahin, Gurses; Corapcioglu, Funda; Keskin Yildirim, Zuhal; PINARLI, FARUK GÜÇLÜ; Olgun, Nur; Sari, Neriman; Dagdemir, Ayhan; Ozyoruk, Derya; Eren, Tuba; ÇAKIR, FATMA BETÜL; Adakli Aksoy, Basak; Bozkurt, Ceyhun; Guler, Elif; Ozguven, Ali Aykan; Erbey, Fatih; Berber, Melda; Dincaslan, Handan; Unal, Emel; Kantar, Mehmet; ÇAKIR, FATMA BETÜLAim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey.Publication Open Access A Difficult Case of Hodgkin Lymphoma with Differential Diagnosis of Tuberculosis and Sarcoidosis.(2015-06-08) GÖKNAR, N; Çakır, FATMA BETÜL; KASAPCOPUR, O; YEGEN, G; GEDIK, AH; OKTEM, F; ÇAKIR, ERKAN; ÇAKIR, FATMA BETÜLWe report here the case of a 14-year-old boy with history of fever, weight loss, and mediastinal lymphadenopathy. The clinical symptoms and laboratory findings mimicking tuberculosis and sarcoidosis complicated the diagnostic process. He was diagnosed with Hodgkin's lymphoma after several X-rays, computed tomography, positron emission tomography-computed tomography, laboratory tests and three lymph node biopsy. Clinicians should be alerted on new lesions and symptoms in high risk patients and should repeat diagnostic tests and lymph node biopsies as indicated.Publication Open Access Ceftriaxone-induced hemolytic anemia in a child successfully managed with intravenous immunoglobulin(2016-03-01) Vehapoglu, AYSEL; GOKNAR, Nilufer; TUNA, Rumeysa; Cakir, FATMA BETÜL; VEHAPOĞLU TÜRKMEN, AYSEL; ÇAKIR, FATMA BETÜLDrug-induced hemolytic anemia is an immune-mediated phenomenon that leads to the destruction of red blood cells. Here, we present a case of life-threatening ceftriaxone-induced hemolytic anemia (CIHA) in a previously healthy 3-year-old girl. We also reviewed the literature to summarize the clinical features and treatment of hemolytic anemia. Acute hemolysis is a rare side effect of ceftriaxone therapy associated with high mortality. Our patient had a sudden loss of consciousness with macroscopic hematuria and her hemoglobin dropped from 10.2 to 2.2 g/dl over 4 hours, indicating that the patient had life-threatening hemolysis after an intravascular dose of ceftriaxone who had previously been treated with ceftriaxone in intramuscular form for six days. CIHA is associated with a positive direct antiglobulin test, revealing the presence of IgG in all cases and C3d in most cases. Our patient's direct antiglobulin test was positive for IgG (3+) and for C3d (4+). The case was managed successfully with supportive measures and intravenous immunoglobulin therapy. Ceftriaxone is used very frequently in children; an early diagnosis and proper treatment of hemolytic anemia are essential to improve the patient outcome. The pathophysiological mechanism is the same as for non-drug autoimmune hemolytic anemia. However, there is still no consensus treatment for CIHA. Intravenous immunoglobulin can be used in clinical emergencies, such as our case, or in refractory cases.Publication Open Access False positivity of magnetic resonance imaging under the effect of granulocyte-colony stimulating factor in a child with leukemia(2013-06-01) ÇAKIR, FATMA BETÜL; Baysal, Begümhan; Doğan, Öner; ÇAKIR, FATMA BETÜLGranulocyte-colony stimulating factor (G-CSF) increases the proliferation and maturation of committed polymorphonuclear leukocyte precursors, as well as the function of mature polymorphonuclear leukocytes. It has previously been shown in pediatric patients that G-CSF induces reconversion of fatty bone marrow to hematopoietic bone marrow in the pelvis and lower extremities that is detectable by magnetic resonance imaging (MRI). Here, we report a 13-year-old Burkitt leukemia patient with bone pain while he was in remission. He was on G-CSF after cessation of high-dose and low-dose cytarabine chemotherapy. He was suspected to have a leukemia relapse. Pelvic MRI was consistent with leukemic infiltration. However, the pathology of bone marrow biopsy resulted in normal findings. Thus it was suggested that concurrent administration of G-CSF could be the causative agent for both bone pain and false-positive MRI findings. The control MRI after interruption of G-CSF revealed normal findings. In conclusion, radiologists should be informed about the type of therapy, including G-CSF administration, in order to overcome misinterpretation of bone marrow MRI.Publication Open Access Evaluation of diagnostic components and management of childhood pulmonary tuberculosis: a prospective study from Istanbul, Turkey.(2022-01-31T00:00:00Z) Dogan Demir, Aysegul; Kut, Arif; Ozaydin, Erhan; Cakir, Fatma Betul; Nursoy, Mustafa; Ustabas Kahraman, Feyza; Erenberk, Ufuk; Uzuner, Selcuk; Collak, Abdulhamit; Cakin, Zeynep Ebru; Cakir, Erkan; ÇAKIR, FATMA BETÜL; USTABAŞ KAHRAMAN, FEYZA; ERENBERK, UFUK; UZUNER, SELÇUK; ÇAKIR, ERKANIntroduction: The diagnosis of childhood tuberculosis is difficult and most of the patients are diagnosed clinically. The objective of this study is to reveal the diagnostic and therapeutic components of childhood pulmonary tuberculosis and to analyze the changes that occurred in our country over the years. Methodology: All patients diagnosed with tuberculosis between 2006 and 2016 were included. Demographic characteristics, diagnostic and treatment outcomes were recorded and patients were followed up prospectively. Results: A total of 492 patients were included in the study. 97% had Bacillus Calmette-Guerin vaccine, 36% were diagnosed with microbiologically-confirmed tuberculosis and 64% were diagnosed with clinically-proven tuberculosis. 94% of the patients had symptoms consistent with tuberculosis, all patients had radiologic findings, 74% had a history of tuberculosis contact and 63% had tuberculin skin test positivity. The diagnoses included primary tuberculosis in 62%, secondary tuberculosis in 21%, progressive primary tuberculosis in 13% and miliary tuberculosis in 4%. 48% of the patients received a treatment regimen containing three drugs as the initial treatment, and drug-related side effects developed in 12%. Isoniazid resistance was detected in 13% of the patients and rifampicin resistance was detected in 8%. None of the patients died due to tuberculosis. In the last 50 years in Turkey, the rates of Bacillus Calmette-Guerin vaccination and diagnosis of tuberculosis cases have increased and the mortality rates have decreased over the years. Conclusions: Our study is one of the few prospective studies and revealed the differences between the recent data and the past 50 years in childhood tuberculosis in Turkey.