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ERENBERK, UFUK

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    SIRT1 gene variants are related to risk of childhood obesity
    (2015-04-01) Kilic, Ulkan; GOK, Ozlem; ELIBOL-CAN, BİRSEN; Ozgen, Ilker Tolga; Erenberk, UFUK; Uysal, Omer; DUNDAROZ, Mehmet Rusen; ELİBOL, BİRSEN; ÖZGEN, İLKER TOLGA; ERENBERK, UFUK; UYSAL, ÖMER
    Obesity is a multifactorial disorder resulting from the interaction between genetic, psychological, physical, environmental, and socioeconomic factors. SIRT1 gene has important effects on the regulation of adiponectin, caloric restriction, insulin sensitivity, coronary atherosclerosis, and cardiovascular diseases. The aim of this study was to investigate the association between childhood obesity and SIRT1 gene polymorphisms regarding rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 using PCR-CTPP method in 120 obese and 120 normal weight children. In this study, BMI, systolic and diastolic blood pressure, LDL cholesterol, triglyceride, and insulin levels were significantly higher and HDL-cholesterol levels were significantly lower in obese children compared to normal weight children. For rs7895833 A > G, the rate of having AG genotype and G allele was significantly higher in obese children compared to non-obese group (p T. There was no significant difference for rs7069102 C > G gene polymorphism between groups.
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    Extraordinary cause of complete colonic obstruction in children: Urinary retention
    (2014-06-01) KILINÇASLAN, Huseyin; SILAY, Mesrur Selcuk; ERDEM, Mehmet Remzi; DÖNMEZ, Tugrul; BİLİCİ, Mustafa; Erenberk, UFUK; ERENBERK, UFUK
    Complete colonic obstruction in children may occur secondary to congenital, and acquired factors related to the gastrointestinal system. Herein, we report an extraordinary presentation of complete colonic obstruction due to extensive urinary retention in a 3-year-old boy. The possible underlying mechanism was detected as urinary infection in a child with horseshoe kidney. The treatment of the bladder symptoms and urinary infection relieved the obstruction of the colon. To our knowledge, especially in children, colonic obstruction due to urinary retention has not been reported in the literature.
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    Evaluation of Autonomic Nervous System function in Children with Overactive Bladder Syndrome
    (2017-03-01) DEMIR, Aysegul Dogan; Gursoy, AZİZE ESRA; GOKNAR, Nilufer; Uzuner, SELÇUK; Ozkaya, EMİN; Erenberk, UFUK; Vehapoglu, Aysel; DUNDAROZ, Mehmet Rusen; OKTEM, Faruk; GÜRSOY, AZIZE ESRA; UZUNER, SELÇUK; ÖZKAYA, EMİN; ERENBERK, UFUK; VEHAPOĞLU TÜRKMEN, AYSEL
    Purpose We aimed to evaluate the autonomic nervous system activity in children with overactive bladder (OAB) syndrome.Methods Included in the study were 40 children with overactive bladder and 28 healthy controls. Autonomic tests were performed on all participants, including heart rate interval variation (RRIV), heart rate response to valsalva maneuver, and sympathetic skin response (SSR).Results Mean valsalva rates in the overactive bladder and control groups were 1.530.29 and 1.30 +/- 0.18, respectively, a statistically significant difference (P0.05).Conclusions This study demonstrated a parasympathetic hyperactivity in children with OAB, results suggesting a dysfunction in their autonomic nervous systems. (C) 2016 Wiley Periodicals, Inc.
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    Melatonin attenuates phenytoin sodium-induced DNA damage
    (2014-04-01) Erenberk, UFUK; DUNDAROZ, Rusen; GOK, Ozlem; Uysal, Omer; AGUS, Sami; Yuksel, Adnan; Yilmaz, Bayram; KILIC, Ulkan; ERENBERK, UFUK; UYSAL, ÖMER
    Phenytoin sodium (PHT Na+) is a potent antiepileptic drug against epileptic seizures and is used as a prophylactic treatment in traumatic brain injury. PHT Na+ leads to the formation of reactive oxygen species (ROS), and DNA is a crucial molecular target of ROS-initiated toxicity. Melatonin and its metabolites possess free-radical-scavenging activity. We therefore designed this study to investigate the potential protective effect of melatonin against PHT Na+-induced DNA damage by using the comet assay in a rat model in vivo. Thirty-three 3-month-old male Wistar rats were divided into five groups of control treated with isotonic sodium chloride (a single injection of isotonic sodium chloride and 100 mL in drinking water for 10 days), ethanol treated (in drinking water for 10 days containing 100 mL of ethanol in each 300-mL drinking bottle), melatonin treated (4 mg/kg body weight [b.w.] intraperitoneally [i.p.] at the start, in drinking water for 10 days), PHT Na+ treated (a single i.p. injection of 50 mg/kg) and PHT Na+ (50 mg/kg b.w., single i.p.) and melatonin (4 mg/kg b.w. i.p. at the start and 4 mg/kg in drinking water for 10 days) cotreated. To determine the protective effects of melatonin, the comet assay was performed using lymphocytes isolated in different time intervals (0, 15, 30, 45 and 60 minutes) from each group of animals. On days 1, 3, 7 and 10, blood samples were taken and the comet assay technique was performed. Our present data suggest that melatonin reversed PHT Na+-induced DNA damage.