Person: BEKTAY, MUHAMMED YUNUS
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Publication Metadata only ASSOCIATION OF PLASMA DIAZEPAM BINDING INHIBITOR WITH INFLAMMATORY, OXIDATIVE STRESS AND NEURODEGENERATIVE MARKERS IN ALZHEIMER-S DISEASE(2021-11-06T00:00:00Z) Gökçe, Mustafa; Bektay, Muhammed Yunus; Velioğlu, Halil Aziz; Güler, Eray Metin; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUSPublication Metadata only Determination of Pharmaceutical Care Needs of COVID-19 Patients in the 1st Wave of Pandemic(2021-09-08T00:00:00Z) Gökçe, Naçize; Bektay, Muhammed Yunus; İzzettin, Fikret Vehbi; BEKTAY, MUHAMMED YUNUS; İZZETTİN, FIKRET VEHBITurkey In 2020 COVID-19 pandemic spread all over the world. A multidisciplinary approach isnecessary for the treatment. The aim of this study is to determine the pharmaceutical care need of COVID-19 patients in the 1st wave of the pandemic. A retrospective, observational study was conducted. After ethical approval was given with 13/274 number, prescription records were investigated by a clinical pharmacist (CP). drug-related problems (DRP)identified through prescription examination. Study was held in 2 branches (i) hospitalized patients (HP) where CP is present and (ii) ambulatory care patients (AP). In this study 183HP and 182 AP patients prescriptions were examined. Half of the participants were female89 (%48.6), 83 (%45.6) for HP and AP respectively. The mean±SD age for HPs and APs were42±18, 42,5±16 respectively. Many participants had multiple comorbidities, in HPs 91(%49.5) at least have 2 or more existing diseases. The median medication number of HPsand APs were 7, 5 respectively. CP identified DRP events for HPs and APs 144, 306respectively. The most common DRP for HPs was using ondansetron instead of metoclopramide. On the other hand, the most prevalent DRP for APs was lack of any gastroprotective medication. DRPs are probable events. Our results demonstrated that HPshad a lower number of DRPs. This points out that CP is a valuable asset to prevent DRPs. In conclusion, every setting where a clinical pharmacist is present should be involved in the healthcare and take responsibility.Publication Open Access Transcranial Magnetic Stimulation (TMS) Applications in Alzheimer-s Disease: A Systematic Review(2021-10-01T00:00:00Z) VelIoglu, Halil Aziz; BEKTAY, MUHAMMED YUNUS; BEKTAY, MUHAMMED YUNUSAlzheimer-s disease (AD), is characterized by its progressive feature and loss of cognitive functions, is common among dementia types. There is no curative treatment of the disease today. In recent years, transcranial magnetic stimulation (TMS) techniques together with drug therapy have been explored by experts considering that they will produce beneficial results. Repetetive TMS (rTMS) can modulate cortical excitability and prevent long-term neuroplastic changes. The aim of this study is an updated and comprehensive systematic review of studies using TMS/rTMS in AD patients. Our study was designed as a systematic review prepared according to the PRISMA guideline. In this study, English and Turkish AD-TMS articles that entered the literature published between 2002 and 2017 were included. Randomized and non-randomized controlled clinical studies on humans evaluating the effectiveness of rTMS applications at different concentrations, durations and different regions in AD have been reviewed. The databases we used were Pubmed (R), MEDLINE (R), Webofscience (R), EMBASE (R), Turkiye Atif Dizini (R). Keywords were -TMS, rTMS, Alzheimers Disease- used in our search, 116 artticles complied with the determined protocol were identified and 14 were included in our study. The studies presented in this review, show the therapeutic potential of rTMS in AD patients. Benefits of rTMS were to communicate with patients and especially caregivers in their daily activities, thereby improving their QoL. The possibility of using TMS to increase neuroplasticity is promising not only to improve our understanding of brain plasticity mechanisms, but also to design new neurorehabilitation strategies.Publication Metadata only Quantifying structural and electromagnetic interference (EMI) shielding properties of thermoplastic polyurethane-carbon nanofiber/magnetite nanocomposites(2016-09-01) Durmus, ZEHRA; Durmus, Ali; Bektay, MUHAMMED YUNUS; Kavas, Huseyin; Unver, Ibrahim Saim; Aktas, Bekir; BEKTAY, MUHAMMED YUNUSIn this study, mixed-structure carbon-magnetite nanocomposites were prepared by decorating of carbon nanofiber (CNF) surfaces with magnetite (Fe3O4) nanoparticles synthesized via reflux method and characterized. The compositions of CNF-Fe3O4 nanocomposites were varied using different amounts of CNF into the Fe3O4 synthesis medium as 25/75, 50/50, and 75/25 (w/w). These nanocomposites were then used as functional fillers to prepare flexible, thermoplastic polyurethane (TPU)-based electromagnetic interference (EMI) shielding composites by solution mixing method. Structural features of fillers, morphological, and electromagnetic properties of flexible composites were studied. It was found that the magnetite nanoparticles with the average size of 8-10 nm were formed and successfully covered the oxidized CNF surfaces. It was also found that the resulting CNF-Fe3O4 nanocomposites exhibited sufficiently high saturation magnetization (M-s) values compared to Fe3O4. These CNF-Fe3O4 nanocomposites were embedded into TPU phase by employing the weight percent of 20 wt%. The flexible TPU-CNF-Fe3O4 nanocomposite having the composition of 80-5-15 wt% showed the reflection loss (RL) value of -32 dB which signified that the composite material could absorb the 97 % of an incident electromagnetic wave at around 12.14 GHz.Publication Metadata only Are Students Using Pharmacological Cognitive Enhancement More Successful?(2021-09-08T00:00:00Z) Sümbül Şekerci, Betül; Bektay, Muhammed Yunus; Bildik, Özlem; İzzettin, Fikret Vehbi; SÜMBÜL ŞEKERCİ, BETÜL; BEKTAY, MUHAMMED YUNUS; BİLDİK, ÖZLEM; İZZETTİN, FIKRET VEHBIIntroduction: The use of psychostimulant drugs to increase academic success is common among young people, especially medical students. However, the effect of psychostimulants on academic success not clear in the current literature. Materials and Methods: A structured online survey was carried out with 431 undergraduate students in different faculties of Medicine in Turkey. Comparisons between groups, correlation and regression analysis about associated variables were made. The academic performance of the students was evaluated with grade point average (GPA) score. Also, academic success, academic anxiety, study performance, sleep quality and pharmacological knowledge levels were questioned with the scale based on self-evaluations. Results: 23 (5.4%) healthy students reported using psychostimulants to improve academic success. There was no significant difference in age, gender, semester, objective (GPA score) and subjective (self-report) assessment of success between users and non-users. But most of the users evaluated that the psychostimulants are useful. Smoking and increased knowledge level of pharmacology are risk factors for psychostimulant use. Conclusion: We could not find a relationship between academic success and pharmacological cognitive enhancement. Psychostimulant use had an positive effect on self-assessment of students. It can support the hypothesis that the psychostimulants has a motivational contribution rather than a purely pharmacological effect. The relationship of psychostimulants with alcohol and smoking should be examined in detail, and users should be questioned in terms of susceptibility to risky behaviors and addiction.Publication Metadata only The role of the clinical pharmacist in patient education and monıtoring of patients under warfarin treatment(2019-01-01) İZZETTİN, FİKRET VEHBİ; SANCAR, MESUT; AKSOY, NİLAY; TEZCAN, SONGÜL; BEKTAY, MUHAMMED YUNUS; İZZETTİN, FIKRET VEHBI; BEKTAY, MUHAMMED YUNUSThis study was carried out on patients who were under anticoagulation treatment with warfarin, at the outpatient cardiology clinic. The aim was to determine the effectiveness of pharmacist consultation, education, and intervention on each patient-s therapeutic results. A cross-sectional randomized trial has been done. Twenty-five patients were included in the study. The Oral Anticoagulation Knowledge (OAK) Test, Short Form-36 (SF-36) and Duke Anticoagulation Satisfaction Scale (DASS) were applied. Patients resumed their routine anticoagulation treatment and INR and complications were recorded during the study. Additionally, patients received patient education, consultation on lifestyle and anticoagulant usage issues from a pharmacist. The same tests were applied again to the patients on the 90th day of the study and the results were compared with the initial test. Maintenance of INR within the target range and complication rates were compared before and after the intervention. Pre-test and post-test results of the patients revealed statistically significant improvements on the physical and mental score components of the SF-36 (p = 0.001; p = 0.001), OAK test scores (p <= 0.001) and the (negative) -limitations- and -burdens- and -positive effects- components of the DASS (p = 0.005; p < 0.001; p = 0.001). The successful maintenance of INR within target range was significantly higher (p = 0.027). The positive effects of pharmacist consultation and education on therapeutic results were demonstrated.Publication Metadata only Evaluation of analgesic use behaviors of individuals for pain management: an observational study(2022-11-25) Köroğlu F.; Mercümek B.; Bektay M. Y.; İzzettin F. V.; MERCÜMEK, BERRE; BEKTAY, MUHAMMED YUNUS; İZZETTİN, FIKRET VEHBIPublication Metadata only Comparision of different decision support software programs in perspective of potential drug-drug interactions in oncology clinic.(2019-10-25T00:00:00Z) ŞEKER, ZEHRA; BEKTAY, MUHAMMED YUNUS; İZZETTİN, FİKRET VEHBİ; Eke, Hatice Kübra; BEKTAY, MUHAMMED YUNUS; ŞEKER, ZEHRA; TÜRK, HACI MEHMET; İZZETTİN, FIKRET VEHBIPublication Metadata only Hepatoselüler Karsinoma, Mide ve Kolorektal Kanser Hastalarında Tedavi Öncesi ve Sonrası Oksidatif Stresin Araştırılması(2019-10-01) Bozbulut, Elif; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS; Serilmez, Murat; Uzun, Mustafa; Aksoy, Turgut; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Investigation of the Anxiety and Knowledge Levels of Individuals: the Role of Pharmacist(2021-09-08T00:00:00Z) Tütüncü, Beyza; Sosyal, Damla; Bektay, Muhammed Yunus; İzzettin, Fikret Vehbi; SOSYAL, DAMLA; BEKTAY, MUHAMMED YUNUS; İZZETTİN, FIKRET VEHBI