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BABALI BALIBEY, FATMANUR

2020-12-16T00:00:00Z, Bulut, Şeyma, Obakan, Pınar, Babalı Balıbey, Fatmanur, Hacıosmanoğlu, Ebru, Bahadori, Fatemeh, BABALI BALIBEY, FATMANUR, HACIOSMANOĞLU, EBRU, BAHADORİ, FATEMEH

2017-02-12T00:00:00Z, ŞEKER, ZEHRA, BEKTAY, MUHAMMED YUNUS, BABALI BALIBEY, FATMANUR, ŞAHİN, HÜMEYRA, ŞEKER, ZEHRA, BEKTAY, MUHAMMED YUNUS, BABALI BALIBEY, FATMANUR

2017-02-12, Şeker Z., Babalı Balıbey F., Şahin Bektay H., Bektay M. Y., ŞEKER, ZEHRA, BABALI BALIBEY, FATMANUR, BEKTAY, MUHAMMED YUNUS

2022-01-01T00:00:00Z, Bilgin, Mehmet Gültekin, Güneş Bayır, Ayşe, Özman, Zeynep, Babalı Balıbey, Fatmanur, Turgay, Feyzanur, Karakaş, İrem, Köse, Nesrin, Sevinç, Tülay, Selçuk, Tuğbanur, Öztürk, Nezire, BİLGİN, MEHMET GÜLTEKİN, GÜNEŞ BAYIR, AYŞE, ÖZMAN, ZEYNEP, BABALI BALIBEY, FATMANUR

2022-12-16, Özman Z., Babalı Balıbey F., Balkan E., Koçyiğit A., ÖZMAN, ZEYNEP, BABALI BALIBEY, FATMANUR, BALKAN, EZGİ, KOÇYİĞİT, ABDÜRRAHİM

2024-06-04, Kocyigit A., Kanimdan E., Yenigun V. B., Ozman Z., Balıbey F. B., Durmuş E., Yasar O., KOÇYİĞİT, ABDÜRRAHİM, YAŞAR, ÖZNUR, KANIMDAN, EBRU, YENİGÜN, VILDAN BETÜL, ÖZMAN, ZEYNEP, BABALI BALIBEY, FATMANUR

Severe acute respiratory syndrome coronavirus 2 poses ongoing global health challenges due to its propensity for mutations, which can undermine vaccine efficacy. With no definitive treatment available, urgent research into affordable and biocompatible therapeutic agents is extremely urgent. Angiotensin converting enzyme-2 (ACEII), transmembrane protease serine subtype 2 (TMPRSS2), and Furin enzymes, which allow the virus to enter cells, are particularly important as potential drug targets among scientists. Olive leaf extract (OLE) has garnered attention for its potential against COVID-19, yet its mechanism remains understudied. In this study, we aimed to investigate the effects of OLE on ACEII, TMPRSS2, and Furin protein expressions by cell culture study. Total phenol, flavonoid content, and antioxidant capacity were measured by photometric methods, and oleuropein levels were measured by liquid LC-HR-MS. Cell viability was analyzed by ATP levels using a luminometric method. ACEII, TMPRSS2, and Furin expressions were analyzed by the Western Blotting method. ACEII, TMPRSS2, and Furin protein expression levels were significantly lower in dose dependent manner and the highest inhibition was seen at 100 ug/ml OLE. The results showed that OLE may be a promising treatment candidate for COVID-19 disease. However, further studies need to be conducted in cells co-infected with the virus.

2017-04-15T00:00:00Z, Babalı Balıbey, Fatmanur, BABALI BALIBEY, FATMANUR