Person: ZENGİN KURT, BELMA
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ZENGİN KURT
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BELMA
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- PublicationMetadata onlyQuinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies.(2021-02-24T00:00:00Z) Zengin Kurt, Belma; Cakmak, Elmas Begum; Ozturk Civelek, DİLEK; Angeli, Andrea; Akdemir, Atilla; Sonmez, Fatih; Supuran, Claudiu T; Kucukislamoglu, Mustafa; ZENGİN KURT, BELMA; ÖZTÜRK CİVELEK, DİLEK
- PublicationMetadata onlySynthesis and Cytotoxic Activity of Coumarin-Carvacrol Derivatives and determination of CA-IX and CA-XII expressions(2018-10-07) ZENGİN KURT, BELMA; Çelebi, Gülşen; ÖZTÜRK, DİLEK; SONMEZ, FATIH; ZENGİN KURT, BELMA; ÖZTÜRK CİVELEK, DİLEK
- PublicationMetadata onlyThree novel Cu(II), Cd(II) and Cr(III) complexes of 6-Methylpyridine-2-carboxylic acid with thiocyanate: Synthesis, crystal structures, DFT calculations, molecular docking and alpha-Glucosidase inhibition studies(2018-12-13) Avci, Davut; Alturk, Sumeyye; Sonmez, Fatih; Tamer, Omer; Basoglu, Adil; Atalay, Yusuf; Kurt, BELMA; Dege, Necmi; ZENGİN KURT, BELMANovel complexes of 6-methylpyridine-2-carboxylic acid and thiocyanate ([Cu(NCS)(6-mpa)(2)], (1); [Cd(NCS)(6-mpa)](n), (2); [Cr(NCS)(6-mpa)(2)center dot H2O], (3)} were synthesized, and their structures were characterized by XRD analysis, FT-IR and UV-Vis spectroscopic techniques. The inhibitory activities of the synthesized complexes (1-3) on alpha-glucosidase were determined by using genistein reference compound. Furthermore, the optimized geometry and vibrational harmonic frequencies for the complexes 1-3 were obtained by DFT/HSEh1PBE/6-311G(d,p)/LanL2DZ level. Electronic spectral properties were examined by using TD-DFT/FISEh1PBE/6-311G(d,p)/LanL2DZ level with CPCM model. Additionally, major contributions to the electronic transitions were determined via Swizard program. The refractive index, linear optical and non-nonlinear optical parameters of the complexes 1-3 were investigated at HSEh1PBE/6 -311G(d,p) level. The docking studies of the complexes 1-3 to the binding site of the target protein (the template structure S. cerevisiae isomaltase are fulfilled. Lastly, natural bond orbital analysis was used to investigate inter- and intra-molecular bonding and interaction among bonds. (C) 2018 Elsevier Ltd. All rights reserved.
- PublicationMetadata onlySinnamaldehitin yeni schiff bazlarının sentezi ve antioksidan özelliklerinin incelenmesi(2018-06-01) ZENGİN KURT, BELMA; ZENGİN KURT, BELMA
- PublicationMetadata onlySynthesis, molecular docking and molecular dynamics studies of novel tacrine-carbamate derivatives as potent cholinesterase inhibitors(2021-10-01T00:00:00Z) Ozten, Ozge; ZENGİN KURT, BELMA; Sonmez, Fatih; Dogan, Berna; Durdagi, Serdar; ZENGİN KURT, BELMA© 2021 Elsevier Inc.In the present study, new tacrine derivatives containing carbamate group were synthesized and their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition activities were evaluated. All synthesized compounds inhibited both cholinesterases at nanomolar level. Among them, ((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl(3-nitrophenyl) carbamate (6k) showed the best inhibitor activity against AChE and BuChE with IC50 value of 22.15 nM and 16.96 nM, respectively. The calculated selectivity index revealed that the synthesized compounds (exclude 6l) have stronger inhibitory activity against BuChE than AChE. The most selective compound was 2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl(4-methoxyphenyl)-carbamate (6b) with the selectivity index of 0.12. Molecular modeling approaches were employed to understand the interaction between the synthesized compounds and proteins. As carbamate derivatives can act as pseudo-irreversible inhibitors of AChE and BuChE, covalent docking approaches was applied to determine the binding modes of novel compounds at binding sites of cholinesterase enzymes.
- PublicationMetadata onlyThe New Synthesis of Coumarylchalcone Derivatives Containing Urea Groups(2014-04-19) ZENGİN KURT, BELMA; SÖNMEZ, FATİH; KÜÇÜKİSLAMOĞLU, MUSTAFA; ZENGİN KURT, BELMA
- PublicationMetadata onlyIn vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives(2016-09-01) Kurt, BELMA; Sonmez, Fatih; GÖKÇE, Başak; Ergun, Adem; Gencer, Nahit; Demir, Taki; Arslan, Oktay; Kucukislamoglu, Mustafa; ZENGİN KURT, BELMACoumarin and heterocyclic compounds incorporating urea have clinical applications as antiepileptics, diuretics, and antiglaucoma agents due to their carbonic anhydrase inhibitory properties. We investigated inhibition of carbonic anhydrase I and II with a series of coumarylthiazole derivatives containing urea/thiourea groups. All the investigated compounds exhibited inhibitory activity on both hCA I and hCA II, with 1-(3-chlorophenyl)-3-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)urea being the strongest inhibitor. Structure-activity relationship study showed that most of urea derivatives were more inhibiting for hCA I and hCA II than thiourea derivatives. The electron-withdrawing groups at the phenyl ring increased the inhibitory activity compared to electron-donating groups.
- PublicationMetadata onlySynthesis and Characterization of Block Copolymers by Combination of Iniferter Polymerization and Click Reactions(2015-10-22) TEMEL, BİNNUR; ZENGİN KURT, BELMA; Çamlık, Gamze; TEMEL, BİNNUR; ZENGİN KURT, BELMA
- PublicationMetadata onlySynthesis, DFT calculations and molecular docking study of mixed ligand metal complexes containing 4,4′-dimethyl-2,2′-bipyridyl as α-glucosidase inhibitors(2020-04-05T00:00:00Z) Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Kurt, BELMA; ZENGİN KURT, BELMA
- PublicationMetadata onlyA new dinuclear copper (II) complex of 2,5– Furandicarboxyclic acid with 4(5)-Methylimidazole as a high potential ?-glucosidase inhibitor: Synthesis, Crystal structure, Cytotoxicity study, and TD/DFT calculations(2019-01-01) Sönmez, Fatih; Basoglu, Adil; Altürk, Sümeyye; Avcı, Davut; Tamer, Ömer; Öztürk, Dilek; Dege, Necmi; Zengin Kurt, Belma; Atalay, Yusuf; ZENGİN KURT, BELMA; ÖZTÜRK CİVELEK, DİLEK