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KIRMIZIKAN, SEDA

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KIRMIZIKAN

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    Publication
    Clues to the Harmful Effects of Aspartame on Liver Morphology and Function
    (2022-12-01) Hekimoğlu E. R.; Elibol B.; Toruntay C.; Kırmızıkan S.; Pasin Ö.; Sarıkaya U.; Alkhalidi D.; Eşrefoğlu M.; HEKİMOĞLU, EMİNE RÜMEYSA; KIRMIZIKAN, SEDA; PASİN, ÖZGE; SARIKAYA, UFUK; EŞREFOĞLU, MUKADDES
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    Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice
    (2022-05-01T00:00:00Z) Kukula, Osman; Kirmizikan, SEDA; Tiryaki, Emre Soner; Cicekli, Mustafa Nusret; Gunaydin, Caner; KIRMIZIKAN, SEDA
    Background: Psoriasis is a common skin disorder related to inflammation and immune response. However, many treatment modalities are present in the clinics, and drug conformity halts chronic treatment. Therefore, novel treatment options are still needed. In this study, the possible protective effect of asiatic acid is one of the active compounds present in Centella Asiatica, was investigated in the imiquimod-induced psoriasis murine model. Methods:Imiquimod (62.5 mg) was administered dorsal skin of the mice for 6 days. Animals were co-treated with low-dose (25 mg/kg, p.o.) and high-dose (100 mg/kg, p.o.) asiatic acid. The dorsal skin of the animals was daily scored for erythema, thickness, and scaling. At the end of the treatments, serum levels of IL-17A and IL-23 were determined by ELISA. Additionally, the dorsal skins of animals were histopathologically evaluated. Results: Asiatic acid (high-dose) prevented imiquimod-induced skin lesions and protected dermal integrity in addition decreasing mast cell infiltration due to the imiquimod. Furthermore, asiatic acid (high-dose) suppressed the imiquimod-induced increase in serum levels of IL-17A and IL-23. Conclusion: These results indicate that asiatic acid showed an anti-psoriatic effect in the imiquimod-induced psoriasis model via mediating IL-17A and IL-23 pathways. Because wound healing properties of asiatic acid are described, further investigations should be carried out to understand deeper mechanisms and possible use in dermatological pathologies such as psoriasis.
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    Publication
    Ageing-related alterations in rat stomach and intestines: A microscopic approach
    (2023-03-01) Kırmızıkan S.; Eşrefoğlu M.; KIRMIZIKAN, SEDA; EŞREFOĞLU, MUKADDES
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    Publication
    Changes in Histological Features, Apoptosis and Necroptosis, and Inflammatory Status in the Livers and Kidneys of Young and Adult Rats
    (2024-01-01) HEKİMOĞLU E. R.; EŞREFOĞLU M.; Elibol B.; KIRMIZIKAN S.; HEKİMOĞLU, EMİNE RÜMEYSA; EŞREFOĞLU, MUKADDES; ELİBOL, BİRSEN; KIRMIZIKAN, SEDA
    Objective: Aging entails a gradual rise in low-grade inflammation affected by cellular degeneration and death. Inflammaging refers to the chronic, low-grade inflammation that occurs alongside the aging process. This study attempts to evaluate the hepatic and renal histological changes, apoptosis and necroptosis rates, and inflammaging status of 6-week-old and 10-month-old rats. Materials and Methods: This study uses 12 male rats separated into two groups: Young Group (6-week-old rats; n = 6), and Adult Group (10-month-old rats; n = 6). Animals were sacrificed under anesthesia. The rats\" livers and kidneys were removed, and each organ tissue was divided into two parts: one for the microscopic examination (H&E and TUNEL immunohistochemistry) and the other for biochemical determination (tumor necrosis factor-alpha [TNF-α], nuclear factor-kappa beta [NF-κB], interleukin1-Beta [IL-1β], IL6, receptor-interacting serine/threonine protein kinase [RIP], and RIP3). Results: The histological features of the livers and kidneys of the 6-week-old rats were consistent with healthy mammalian organ features, while some histological changes were detected in sections of the 10-month-old rats. The apoptosis rate indicated by TUNEL immunohistochemistry was seen to have increased in the 10-month-old rats, while the necroptosis rate indicated by RIP3 Western-blotting analysis was conversely determined to have decreased. Significant increases in TNF-α and NF-κB levels were consistent with the increased apoptosis rate in the 10-month-old rats compared to the 6-week-old rats. Conclusion: One of the striking results of this study is that the degenerative changes related to aging began to be seen even in 10-month-old rats. The researchers used healthy rats of this age as control subjects as well as to create experimental models.