Person: KURT, GÖKMEN
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Publication Metadata only Effects of cell-mediated osteoprotegerin gene transfer and mesenchymal stem cell applications on orthodontically induced root resorption of rat teeth(2018-06-21T00:00:00Z) GÜL AMUK, NİSA; KURT, GÖKMEN; BARAN, YUSUF; SEYRANTEPE, VOLKAN; KARTAL YANDIM, MELİS; ADAN, AYSUN; DEMİR AKYILDIZ, SEÇİL; KİRAZ, YAĞMUR; SÖNMEZ, MEHMET FATİH; KURT, GÖKMENPublication Metadata only Effects of Photobiomodulation and Ultrasound Applications on Orthodontically Induced Inflammatory Root Resorption; Transcriptional Alterations in OPG, RANKL, Cox-2: An Experimental Study in Rats(2018-12-01) Amuk, Nisa Gul; Kurt, GÖKMEN; Güray, Enis; KURT, GÖKMENObjective: The aim of this study was to evaluate and compare the reparative and inhibitory effects of a light-emitting diode-mediated photobiomodulation (PBM) and of a low-intensity pulsed ultrasound (LIPUS) on orthodontically induced inflammatory root resorption (OIIRR). Materials and methods: Forty-nine Wistar rats were divided into four groups: untreated group (negative control), group treated with orthodontic appliances (positive control), PBM-treated group (wavelength: 618 nm, output power density: 20 mW/cm(2)), and LIPUS-treated group (frequency: 1.5% +/- 5% MHz, pulse repetition ratio: 1.0% +/- 10% kHz, effect area: 3.88% +/- 1% cm(2) and intensity: 30% +/- 30% mW/cm(2)). OIIRR was induced experimentally in rats for 14 days with an applied force of 100g, and therapeutic approaches were performed concurrently. At the end of the experiment, upper first molar teeth of rats were prepared for genetic analysis, scanning electron microscopy, hematoxylin and eosin staining, and tartrate-resistant acid phosphatase staining. Kruskal-Wallis and post hoc Dunn-s tests were performed. Results: Number of osteoclasts (p < 0.01), number of resorption lacunae and resorption area ratio (p < 0.001) decreased and number of total cells (p < 0.001) increased with the PBM and LIPUS applications when compared with the positive control group. Receptor activator of nuclear factor kappa B ligand (RANKL) levels of PBM and LIPUS groups were lower (p < 0.001), and osteoprotegerin (OPG) levels were higher (p < 0.001) than the positive control group. Cyclooxygenase-2 (Cox-2) expression significantly decreased with LIPUS and PBM administrations (p < 0.05). No significant difference was observed among PBM and LIPUS groups. Conclusions: PBM and LIPUS applications showed marked inhibitory and reparative effects on OIIRR by modulating the OPG/RANKL ratio, Cox-2 expression, and cell differentiation of osteoblasts and osteoclasts.Publication Open Access A minimally invasive transfer method of mesenchymal stem cells to the intact periodontal ligament of rat teeth: a preliminary study(2018-01-01) GÜL AMUK, NİSA; KURT, GÖKMEN; YANDIM KARTAL, MELIS; ADAN, AYSUN; BARAN, YUSUF; KURT, GÖKMENThe aim of this study was to introduce a minimally invasive procedure for mesenchymal stem cell (MSC) transfer into the intact periodontal ligament (PDL) of the molar teeth in rats. Ten 12-week-old Wistar albino rats were used for this preliminary study. MSCs were obtained from bones of two animals and were labeled with green fluorescent protein (GFP). Four animals were randomly selected for MSC injection, while 4 animals served as a control group. Samples were prepared for histological analysis, Cox-2 mRNA expression polymerase chain reaction analysis, and fluorescent microscopy evaluation. The number of total cells, number of osteoclastic cells, and Cox-2 mRNA expression levels of the periodontal tissue of teeth were calculated. The number of total cells was increased with MSC injections in PDL significantly (P < 0.001). The number of osteoclastic cells and Cox-2 mRNA expression were found to be similar for the two groups. GFP-labeled MSCs were observed with an expected luminescence on the smear samples of the PDL with transferred MSCs. The results of this preliminary study demonstrate successful evidence of transferring MSCs to intact PDL in a nonsurgical way and offer a minimally invasive procedure for transfer of MSCs to periodontal tissues.Publication Metadata only The effects of different desensitizer agents on shear bond strength of orthodontic brackets after home bleaching: an in vitro study(2018-05-01T00:00:00Z) GÜL AMUK, NİSA; BAYSAL, ASLI; ÜSTÜN, YAKUP; KURT, GÖKMEN; KURT, GÖKMENPublication Metadata only Development of a new three-directional distractor system for the correction of maxillary transverse and sagittal deficiency(2018-03-01) Asan, Canay Yilmaz; Kutuk, NÜKHET; Kurt, GÖKMEN; Alkan, ALPER; KÜTÜK, NÜKHET; KURT, GÖKMEN; ALKAN, ALPERPurpose: Class 3 malocclusions with maxillary deficiency, which are treated surgically and/or ordonotically, are common among adult patients. The aim of this study was to develop a three-directional bone-borne distractor that would allow the transverse expansion and sagittal advancement of the maxilla simultaneously.Publication Metadata only Rapid canine retraction by dentoalveolar distraction osteogenesis response(2018-01-01T00:00:00Z) Kurt, GÖKMEN; Iseri, Haluk; Kisnisci, Reha; ÖZKAYNAK, Ozkan; KURT, GÖKMENPublication Unknown Şiddetli İskeletsel Maksiller Darlığın Transpalatal Distraksiyon ile Tedavisi(2018-10-13T00:00:00Z) KURT, GÖKMEN; TÜRKER, GÖKHAN; GÜL AMUK, NİSA; KÜTÜK, NÜKHET; KURT, GÖKMEN; KÜTÜK, NÜKHET