Person: TOPÇU, GÜLAÇTI
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Publication Metadata only Effect of a combination in situ gel-forming nasal delivery system on nasal mucosa damage repair in rabbits(2017-10-17) AKSOY, FADLULLAH; DOĞAN, REMZİ; OZTURAN, ORHAN; ALTUNTAŞ, EBRU; YENER, FATMA GÜLGÜN; TOPÇU, GÜLAÇTI; GÜLER, BERİL; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; TOPÇU, GÜLAÇTI; GÜLER, BERILPublication Metadata only Biological Activities and Chemical Composition of Ferulago idaea(2015-06-12) Aslan, Esin; DİNCEL, DEMET; Çakar, Begüm; TOPÇU, GÜLAÇTI; DİNCEL, DEMET; TOPÇU, GÜLAÇTIPublication Metadata only Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption(2019-01-01T00:00:00Z) Sen, Alaattin; Ayar, Buket; Yilmaz, Anil; Acar, Ozden Ozgun; Turgut, Gurbet Celik; TOPÇU, GÜLAÇTI; YILMAZ, ANIL; TOPÇU, GÜLAÇTITeucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium. The lactate dehydrogenase (LDH) cytotoxicity assay, glucose uptake test, glucose utilization (glycogen content) test, glucose transport test, glucose absorption (a-glucosidase activity) test, insulin secretion test, RNA isolation and cDNA synthesis assay, qPCR quantification assays, and statistical analyses were carried out in the present study. Alysine A exerted the following effects at non-cytotoxic doses:Publication Metadata only Isolation and Structure Elucidation of the Constituents of Some Anatolian Nepeta Species with Bioactivities(2013-09-02T00:00:00Z) Topçu, Gülaçtı; Yılmaz, Anıl; TOPÇU, GÜLAÇTIPublication Metadata only Evaluation of fruit extracts of six Turkish Juniperus species for their antioxidant, anticholinesterase and antimicrobial activities(2011-03-30T00:00:00Z) Ozturk, Mehmet; Tumen, Ibrahim; Ugur, Aysel; Aydogmus-Ozturk, Fatma; Topcu, GÜLAÇTI; TOPÇU, GÜLAÇTIBACKGROUND: Juniperus L. (Cupressaceae) species are mostly spread out in the Northern Hemisphere of the world, and some of them are used as folkloric medicines. The fruits of some species are eaten. Since oxidative stress is one of the reasons for neurodegeneration and is associated with the Alzheimer-s disease (AD), the extracts prepared from the fruits of six Juniperus species were screened for their antioxidant activity. Therefore, the extracts were also evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), which are chief enzymes in the pathogenesis of AD. In addition, antimicrobial activity was also evaluated.Publication Metadata only Investigation of Anticholinesterase Activity of a Series of Salvia Extractsand the Constituents of Salvia staminea(2013-03-01) Topçu, Gülaçtı; Boğa, Mehmet; Kolak, Ufuk; Öztürk, Mehmet; Dirmenci, Tuncay; Bahadori, Fatemeh; Bütün, Burcu; TOPÇU, GÜLAÇTI; BAHADORİ, FATEMEH; BÜTÜN, BURCUPublication Metadata only Synthesis of New Oleanane Triterpenoids Including Fatty Acids Esters and Investigation of Their in vitro Cytotoxic Effects on 3T3 Fibroblast and PC3 Prostate Cancer Cell Lines(2019-12-19) Dağ, Aydan; Topçu, Gülaçtı; Atasoy, Sezen; Aktaş, Asude Sena; Şenol, Halil; ŞENOL, HALIL; DAĞ, AYDAN; ATASOY, SEZEN; TOPÇU, GÜLAÇTIPublication Metadata only Ursolik Asit ve Oleanolik Asitten Hareketle alfa-Amirin ve beta-Amirin Sentezi için Yeni ve Etkin Bir Yöntem(2017-04-29) SEÇEN, HASAN; ŞENOL, HALİL; TOPÇU, GÜLAÇTI; TUNCAY, SALİH; ÖCAL, NÜKET; ŞENOL, HALIL; TOPÇU, GÜLAÇTIPublication Metadata only Abietane diterpenoids as butyrylcholinesterase inhibitors from Salvia species(2012-08-01) Topcu, GÜLAÇTI; Akdemir, ATİLLA; Öztürk, Mahmut Serdar; Boğa, Miray; Kola, U.; TOPÇU, GÜLAÇTI; AKDEMİR, ATİLLAPublication Metadata only Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada(2015-11-01) Butun, Burcu; Hatipoglu, Seda Damla; Dönmez, Ayşe; Topcu, Gülaçtı; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIThe methanol extract of the aerial parts of Salvia trichoclada Bentham (Lamiaceae) was studied for bioactive non-volatile secondary metabolites, and nine compounds were isolated. Structures of the isolated compounds were elucidated as lupeol (1), lupenone (2), glochidone (3), monogynol A (4), oleanolic acid (5), ursolic acid (6), beta-sitosterol (7), apigenin-7-O-rhamnoside (8), and rosmarinic acid (9) by using 1D and 2D-NMR spectroscopic techniques. A lupane triterpene glochidone was isolated from a Salvia species and Lamiaceae family for the first time in this study. The antioxidant potential of the extract and the isolated compounds were carried out by using lipid peroxidation inhibitory activity (beta-carotene bleaching method) and DPPH free radical scavenging activity test assays. Their anticholinesterase activity was investigated by the Ellman method against both acetylcholinesterase (AChE) and butyrylcholinesterase enzymes. Compounds 1, 3, 5, 6, 8 and 9 showed fairly high anticholinesterase activity almost at all concentrations. Among them, a flavone glycoside apigenin-7-O-rhamnoside exhibited the highest and selective AChE inhibitory activity. Glochidone (3) was found to be the most active one among the isolated lupanes, which exhibited a close activity to that of standard compound galanthamine. Among all the tested compounds, rosmarinic acid (9) exhibited highest antioxidant and good anticholinesterase activity.