Person: NADİR, AYDIN
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Publication Metadata only The frequency, serial changes and clinical characteristics of cardiac troponin release in patients with acute heart failure syndrome(2011-08-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; Gencer, E.; Tek, M.; BİLGİN, MUZAFFER; Nadiradze, AYDIN; BİRDANE, ALPARSLAN; GÖRENEK, BÜLENT; Unalir, A.; ATA, NECMİ; NADİR, AYDINPublication Metadata only Effects of levosimendan and dobutamine on systolic time intervals in patients with acute decompensated heart failure(2013-05-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; Nadir, AYDIN; MERT, KADİR UĞUR; Gencer, E.; MUTLU, FEZAN; ULUS, TANER; NADİR, AYDINPublication Metadata only Ivabradine treatment prevents dobutamine-induced increase in heart rate in patients with acute decompensated heart failure(2015-09-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; MERT, KADİR UĞUR; Nadir, AYDIN; MUTLU, FEZAN; Morrad, Bektas; ULUS, TANER; NADİR, AYDINBackground Ivabradine is a heart rate (HR)-lowering agent acting by inhibiting the I-f-channel. Dobutamine does increase the HR and has some deleterious effects on myocardium. So, we aimed to evaluate whether ivabradine treatment blunts a dobutamine-induced increase in HR.Publication Metadata only Ivabradine treatment blunts dobutamine-induced increase in heart rate in patients with acute decompensated heart failure: a comparative study with beta-blocker therapy(2013-05-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; MERT, KADİR UĞUR; Nadir, AYDIN; MUTLU, FEZAN; Gencer, E.; ULUS, TANER; NADİR, AYDINPublication Metadata only Comparison of the Effects of Levosimendan Dobutamine and Vasodilator Therapy on Ongoing Myocardial Injury in Acute Decompensated Heart Failure(2017-03-01T00:00:00Z) Gencer, Erkan; Dogan, Volkan; Ozturk, Mujgan Tek; Nadir, AYDIN; MUSMUL, AHMET; ÇAVUŞOĞLU, YÜKSEL; NADİR, AYDINBackground: Cardiac troponins (cTn) are reliable and the most sensitive biomarker in the setting of acute decompensated heart failure (ADHF). Acute decompensated heart failure is usually associated with worsening chronic heart failure, and it may be caused by ongoing minor myocardial cell damage that may occur without any reported precipitating factors. Methods: We compared the short-term effect of levosimendan (LEV), dobutamine (DOB), and vasodilator treatment (nitroglycerin [NTG]) on myocardial injury with hemodynamic, neurohumoral, and inflammatory indicators. One hundred twenty-two patients with a mean age of 66 +/- 9 years were treated with LEV (n = 40), DOB (n = 42), and NTG (n = 40) and examined retrospectively. Blood samples (cTnI, N-terminal probrain natriuretic peptide [NT-proBNP], highly sensitive C-reactive protein [HsCRP], and others), left ventricular ejection fraction (LVEF), systolic pulmonary artery pressure (sPAP), and 6-minute walk distance (6MWD) were compared before and after treatment. Results: At admission, detectable levels of cTnI were observed in 53% of patients (>= 0.05 ng/mL). Serial changes in the mean cTnI levels were not significantly different between the groups (LEV 0.04 +/- 0.01 to 0.03 +/- 0.01 ng/mL; DOB 0.145 +/- 0.08 to 0.08 +/- 0.03 ng/mL; NTG 0.1 +/- 0.03 to 0.09 +/- 0.02 ng/mL; overall P = .859). Favourable effects on the NT-proBNP, sPAP values, LVEF, 6MWD, and HsCRP were observed overall, especially in the LEV groups. Conclusion: Beneficial effects of short-term use of LEV, DOB, and NTG on ongoing myocardial injury were demonstrated. These findings can be attributed to the anti-ischemic properties as well as the hemodynamic, neurohumoral, and functional benefits from the positive inotropes, especially LEV, in patients with ADHF.Publication Metadata only Cardiovascular involvement in patients with pseudoexfoliation syndrome(2013-08-01T00:00:00Z) ULUS, TANER; Nadir, AYDIN; Yaz, Yasemin Aydin; ÖZDEMİR, ATİLLA ÖZCAN; MUTLU, FEZAN; Yazici, Huseyin Ugur; ÇAVUŞOĞLU, YÜKSEL; YILDIRIM, NİLGÜN; NADİR, AYDINAimPseudoexfoliation (PEX) syndrome, diagnosed by ocular examination, is a common disorder of the extracellular matrix. Previous studies have demonstrated accumulation of PEX material in the walls of blood vessels and myocardium. We aimed to investigate whether PEX is associated with cardiovascular involvement using carotid ultrasound measurements and myocardial tissue Doppler imaging (TDI).MethodsThirty-six PEX patients and 34 age-matched and sex-matched healthy controls who had no PEX material were included. Fasting blood samples were taken and the following data were obtained from all cases: myocardial TDI measurements, the mean carotid intima-media thickness (IMT), total carotid plaque area and number.ResultsThere were no significant differences between the groups regarding clinical and biochemical data. The peak systolic TDI velocities at the septal (septal S) and lateral annuli (lateral S), and the isovolumic contraction velocity at the lateral annulus [lateral isovolumic contraction velocity (IVC)] were significantly lower in patients with PEX, than in controls (P=0.001, <0.001 and 0.016, respectively) whereas IMT, total carotid plaque area and number were significantly higher (P=0.002, 0.035 and 0.033, respectively). In a logistic regression analysis including age, septal S, lateral S, lateral IVC, IMT, total carotid plaque area and number, septal S, lateral S and IMT were significantly associated with PEX, (P=0.035, 0.011 and 0.035, respectively).ConclusionPeak systolic TDI velocities were significantly lower and IMT was significantly increased in patients with PEX. However, PEX was weakly associated with carotid plaque measurements.