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AÇIKGÖZ, NUSRET

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Author: PEKDEMİR, HASAN × End date: 2011 × Start date: 2011 ×

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Now showing 1 - 7 of 7
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    Comparison of atrial electromechanical coupling interval and P-wave dispersion in non-dipper versus dipper hypertensive subjects
    (2011-02-01T00:00:00Z) Acikgoz, Nusret; ERMİŞ, NECİP; Cuglan, Bilal; CANSEL, MEHMET; Yagmur, Julide; Tasolar, Hakan; Barutcu, Irfan; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Background. The lack of nocturnal BP fall less than 10% of the daytime, called non-dipper hypertension, is associated with increased cardiovascular morbidity and mortality. The aim of our study was to investigate atrial conduction time in patients with non-dipper hypertension using electromechanical coupling interval and P-wave dispersion (PWD), measured with the surface electrocardiogram and tissue Doppler echocardiographic imaging (TDI). Methods. Age-and sex-matched 43 dipper hypertensive patients (19 male, 24 female, mean age: 53.9 +/- 10.5 years), 40 non-dipper patients (18 male, 22 female, mean age 54.3 +/- 9.6 years) and 46 healthy subjects (22 male, 24 female, mean age: 52.8 +/- 9.6 years) were included in the study. The difference between the maximum and minimum P-wave durations was calculated and defined as PWD. Atrial electromechanical coupling (PA), inter-atrial and intra-atrial electromechanical delays were measured with TDI. Results. PWD was significantly higher in patients with non-dippers compared with dippers (p < 0.02) and controls (p < 0.001). The inter-atrial conduction time was delayed in non-dippers compared with dippers (p < 0.01) and controls (p < 0.001). There was a positive correlation between left atrial (LA) diameter and inter-atrial conduction times (r = 0.46, p < 0.001). LA diameter was also correlated with PWD (r = 0.44, p < 0.001). Conclusion. The patients with non-dipper hypertension have higher P-wave duration, PWD and delayed inter-atrial electromechanical coupling intervals compared with those of dippers and controls. This indicates that these subjects may be more prone to atrial rhythm disturbances.
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    Elevated Oxidative Stress Markers and its Relationship With Endothelial Dysfunction in Behcet Disease
    (2011-05-01T00:00:00Z) Acikgoz, Nusret; ERMİŞ, NECİP; Yagmur, Julide; CANSEL, MEHMET; Karincaoglu, Yelda; Atas, Halil; Cuglan, Bilal; Barutcu, Irfan; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Behcet-s disease (BD) is a multisystemic disorder characterized by endothelial dysfunction. However, the relationship between oxidative stress and endothelial function has not been clearly shown. We investigated the relationship between oxidative stress markers and endothelial function in patients with BD. Patients with BD (n = 40) having active disease and sex-and age-matched 40 controls were included. Endothelial function was assessed by flow-mediated dilatation (FMD) technique. Serum gammaglutamyltransferase (GGT) and high-sensitive C-reactive protein levels (hsCRP) were measured in all participants. Brachial artery FMD was significantly lower in patients with BD than in controls. Gamma-glutamyltransferase and hsCRP levels were higher in patients with BD than in controls. Also, GGT and hsCRP levels were inversely correlated with endothelial function. Oxidative stress markers are elevated in patients with BD having active disease. This may be one of the reasons behind the vasculitis in active BD.
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    Assessment of Atrial Electromechanical Delay by Tissue Doppler Echocardiography in Obese Subjects
    (2011-04-01T00:00:00Z) Acikgoz, Nusret; Yagmur, Julide; CANSEL, MEHMET; ERMİŞ, NECİP; Yagmur, Murat; Atas, Halil; Tasolar, Hakan; Karakus, Yasin; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Our aim was to evaluate whether atrial electromechanical delay measured by tissue Doppler imaging (TDI), which is an early predictor of atrial fibrillation (AF) development, is prolonged in obese subjects. A total of 40 obese and 40 normal-weight subjects with normal coronary angiograms were included in this study. P-wave dispersion (PWD) was calculated on the 12-lead electrocardiogram (ECG). Systolic and diastolic left ventricular (LV) functions, inter-and intra-atrial electromechanical delay were measured by TDI and conventional echocardiography. Inter-and intra-atrial electromechanical delay were significantly longer in the obese subjects compared with the controls (44.08 +/- 10.06 vs. 19.35 +/- 5.94 ms and 23.63 +/- 6.41 vs. 5.13 +/- 2.67 ms, P < 0.0001 for both, respectively). PWD was higher in obese subjects (53.40 +/- 5.49 vs. 35.95 +/- 5.93 ms, P < 0.0001). Left atrial (LA) diameter, LA volume index and LV diastolic parameters were significantly different between the groups. Interatrial electromechanical delay was correlated with PWD (r = 0.409, P = 0.009), high-sensitivity C-reactive protein (hsCRP) levels (r = 0.588, P < 0.0001). Interatrial electromechanical delay was positively correlated with LA diameter, LA volume index, and LV diastolic function parameters consisting of mitral early wave (E) deceleration time (DT) and isovolumetric relaxation time (IVRT; r = 0.323, P = 0.042; r = 0.387, P = 0.014; r = 0.339, P = 0.033; r = 0.325, P = 0.041; respectively) and, negatively correlated with mitral early (E) to late (A) wave ratio (E/A) (r = -0.380, P = 0.016) and myocardial early-to-late diastolic wave ratio (E-m/A(m)) (r = -0.326, P = 0.040). This study showed that atrial electromechanical delay is prolonged in obese subjects. Prolonged atrial electromechanical delay is due to provoked low-grade inflammation as well as LA enlargement and early LV diastolic dysfunction in obese subjects.
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    Subclinical left ventricular dysfunction in Behcet-s disease assessed by two-dimensional speckle tracking echocardiography
    (2011-07-01T00:00:00Z) Yagmur, Julide; ŞENER, SERPİL; Acikgoz, Nusret; CANSEL, MEHMET; ERMİŞ, NECİP; Karincaoglu, Yelda; Tasolar, Hakan; Karakus, Yasin; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Aims The aim of this study was to evaluate the left ventricular (LV) systolic strain by speckle tracking echocardiography (STE) in order to provide the early detection of myocardial dysfunction in patients with Behcet-s disease (BD). We also aimed to examine the relationship between LV systolic strain and N-terminal pro-B type natriuretic peptide (NT-proBNP), which is a cardiac biomarker of ventricular dysfunction.
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    Early single clinical experience with the new Figulla ASD Occluder for transcatheter closure of atrial septal defect in adults
    (2011-03-01T00:00:00Z) CANSEL, MEHMET; Acikgoz, Nusret; PEKDEMİR, HASAN; Yagmur, Julide; Tasolar, Hakan; ERMİŞ, NECİP; Kurtoglu, Ertugrul; Atas, Halil; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Background. Recently, the Occlutech Figulla ASD Occluder (FSO) has been introduced for transcatheter closure of atrial septal defects. This device can be used for transcatheter closure of small as well as large atrial septal defects.
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    The evaluation of mean platelet volume levels in patients with idiopathic and ischemic cardiomyopathy: an observational study
    (2011-11-01T00:00:00Z) Acikgoz, Nusret; ERMİŞ, NECİP; Yagmur, Julide; CANSEL, MEHMET; Atas, Halil; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Objective: Cardiomyopathy (CMP) is a disorder associated with an increased risk of thromboembolism due to blood stasis, platelet activation and altered coagulation status. In this study, we aimed to investigate mean platelet volume (MPV) in patients with idiopathic CMP and ischemic CMP and to compare with those of the controls, and aimed to determine whether there is a relationship between MVP and echocardiographic parameters in patients with CMP.
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    Effects of Transcatheter Closure of Atrial Septal Defects on Heart Rate Variability
    (2011-03-01T00:00:00Z) Acikgoz, N.; CANSEL, MEHMET; Yagmur, J.; ERMİŞ, NECİP; Tasolar, H.; Atas, H.; Muezzinoglu, K.; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    This study evaluated heart rate variability and its changes in 30 patients before and after transcatheter closure of secundum atrial septal defects. Heart rate variability data from 30 healthy volunteers with normal echocardiographic parameters and no history of atrial septal defects were included as controls. Values for the SD of all the normal RR intervals (SDNN), the SD of the means of all the 5-min segment normal RR intervals (SDANN), and the mean of all the 5-min SDs of normal RR intervals during the 24-h period (SDNN index) in patients with atrial septal defects before transcatheter closure were statistically significantly different from controls. At 6 months after closure of the defects these values were not statistically different from controls. It is concluded that transcatheter closure of secundum atrial septal defects had positive effects on heart rate variability and, consequently, may contribute to less mortality and morbidity.