Person: AÇIKGÖZ, NUSRET
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Publication Metadata only Response: Is Mean Platelet Volume Increased in Behcet-s Disease with Thrombosis?(2010-11-01T00:00:00Z) Acikgoz, NUSRET; Karincaoglu, Yelda; ERMİŞ, NECİP; Yagmur, Julide; Atas, Halil; Kurtoglu, Ertugrul; CANSEL, MEHMET; Barutcu, Irfan; PEKDEMİR, HASAN; ÖZDEMİR, RAMAZAN; AÇIKGÖZ, NUSRETPublication Metadata only Elevated serum gamma-glutamyl transferase activity in patients with cardiac syndrome X and its relationship with carotid intima media thickness(2010-10-01T00:00:00Z) Acikgoz, Nusret; Yagmur, Julide; ERMİŞ, NECİP; Cansel, Mehmet; Atas, Halil; Karakus, Yasin; Pekdemir, Hasan; Ozdemir, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZANObjectives - We aimed to evaluate serum gamma-glutamyl transferase (GGT) activity and its relationship with carotid intima media thickness (CIMT) in patients with cardiac syndrome X (CSX).Publication Metadata only Increased Mean Platelet Volume in Behcet-s Disease with Thrombotic Tendency(2010-06-01T00:00:00Z) Acikgoz, Nusret; Karincaoglu, Yelda; ERMİŞ, NECİP; Yagmur, Juelide; Atas, Halil; Kurtoglu, Ertugrul; CANSEL, MEHMET; Barutcu, Irfan; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZANThe relationship between Behcet-s disease (BD) and platelet aggregation has not sufficiently been investigated yet. Mean platelet volume (MPV) is a marker of platelet function, and the increase in MPV has been identified as an independent risk factor of recurrent vascular events. BD is characterized by a relapsing vasculitis of the venous as well as arterial thrombosis. However, the precise pathogenic mechanisms underlying thrombotic tendency in BD are not known. We hypothesized that there might be an association between thrombotic complication and MPV in these patients. Therefore, we investigated activation of platelets in patients with BD using a simple marker, MPV, the most accurate measure of platelet size. A total of 60 patients with BD and 40 age- and gender-matched controls were included. The BD patients were divided into subgroups based on the presence (n = 22) or absence of thrombosis (n = 38) and clinically active (n = 30) or inactive (n = 30) state. MPV was higher in patients with BD than controls (8.14 +/- 0.8 vs. 7.48 +/- 0.3 fl, p = 0.001). Among BD patients, MPV was larger in patients with thrombosis than those without thrombosis (8.45 +/- 1.0 vs. 7.96 +/- 0.7 fl, p = 0.038). However, there was no significant difference in MPV between BD patients with active and inactive states. The increase in MPV is independent of the disease activity, and the presence of thrombosis is associated with higher MPV in BD patients. Therefore, antiplatelet therapy may be useful to prevent thrombotic complications in BD patients.Publication Metadata only Assessment of atrial conduction time by tissue Doppler echocardiography and P-wave dispersion in patients with mitral annulus calcification(2010-07-01T00:00:00Z) Acikgoz, Nusret; PEKDEMİR, HASAN; CANSEL, MEHMET; Yagmur, Julide; ERMİŞ, NECİP; Kurtoglu, Ertugrul; Tasolar, Hakan; Atas, Halil; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZANThe aim of our study was to investigate atrial conduction time in patients with mitral annulus calcification (MAC) using P-wave dispersion (PWD) and electromechanical coupling measured with the surface electrocardiogram and the tissue Doppler echocardiography. Fifty-nine patients with MAC and 43 control subjects underwent resting the surface electrocardiogram and tissue Doppler echocardiography. The difference between the maximum (Pmax) and minimum P-wave durations was calculated and defined as PWD. Interatrial and intraatrial electromechanical delays were measured with tissue Doppler echocardiography. Both Pmax and PWD were higher in patients with MAC compared with controls (111.4 +/- 15.8 vs 97.3 +/- 18.8 milliseconds; P < .0001 and 46.4 +/- 14.6 vs 31.4 +/- 13.1 milliseconds; P < .0001, respectively). Both interatial and intraatrial conduction time were also delayed in patients with MAC compared with controls (29.8 +/- 13.3 vs 17.6 +/- 12.5 milliseconds; P < .0001; 9.4 +/- 5.1 vs 6.8 +/- 4.0 milliseconds; P < .008, respectively). Left atrial (LA) diameter was significantly higher in patients with MAC compared with controls (35.4 +/- 5.0 mm vs 32.3 +/- 4.2 mm; P < .001). The LA diameter correlated significantly with both interatrial conduction times and PWD (r = 0.56; P < .0001 and r = 0.47; P < .0001, respectively). There is a delay in both intraatrial and interatrial electromechanical coupling intervals in patients with MAC. (C) 2010 Elsevier Inc. All rights reserved.Publication Metadata only P wave dispersion and atrial electromechanical delay in patients with prehypertension(2010-09-01T00:00:00Z) ERMİŞ, NECİP; Acikgoz, NUSRET; Yasar, E.; Tasolar, H.; Atas, H.; PEKDEMİR, HASAN; Yagmur, J.; CANSEL, MEHMET; ÖZDEMİR, RAMAZAN; AÇIKGÖZ, NUSRET