Person: MATUR, ZELİHA
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Publication Metadata only Somatosensory Evoked Potentials In Patients With Juvenile Myoclonic Epilepsy(2016-01-01T00:00:00Z) Ozemir, Zeynep Aydin; Matur, ZELİHA; BAYKAL, Betül; ÖGE, Ali Emre; MATUR, ZELİHAWhile a small number of studies dealing with somatosensory evoked potential (SEP) have demonstrated hyperexcitability in the primary somatosensory cortex of juve-nile myoclonic epilepsy (JME) patients, the underlying mechanisms have yet to be illuminated. Determination of higher cortical SEP responses in some JME patients and recordings of very high amplitude responses, called -giant SEP,- in a specific subgroup may indicate a clinical and possibly genetic heterogeneity within JME patients. In the present review, the findings of previous studies concerned with SEP in JME patients are summarized, and their importance regarding JME etiopathogenesis and related clinical findings is discussed.Publication Metadata only Restless Legs Syndrome in Patients with Behcet-s Disease and Multiple Sclerosis: Prevalence, Associated Conditions and Clinical Features(2020-03-01T00:00:00Z) Onalan, Aysenur; Matur, ZELİHA; Pehlivan, Munevver; Akman, Gulsen; MATUR, ZELİHAIntroduction: To investigate the prevalence and characteristics of Restless Legs Syndrome (RLS) in patients with Behcet-s Disease (BD) and Multiple Sclerosis (MS).Publication Metadata only Clinical, Electrophysiological, and Serological Evaluation of Patients with Cramp-Fasciculation Syndrome(2017-06-01T00:00:00Z) Poyraz, Muruvvet; Matur, ZELİHA; Aysal, Fikret; TÜZÜN, Erdem; Hanoglu, Lutfu; ÖGE, Ali Emre; MATUR, ZELİHAIntroduction: Cramp-fasciculation syndrome (CFS) is a rare peripheral nerve hyperexcitability syndrome. There are only a few reports on clinical and serological profile of a CFS cohort that was followed up by a single outpatient clinic.Publication Metadata only Evaluation of OnabotulinumtoxinA Treatment in Patients with Concomitant Chronic Migraine and Temporomandibular Disorders(2018-12-01T00:00:00Z) Kocaman, Gulsen; Kahraman, Nese; Gurkan Koseoglu, Banu; Bilgic, Basar; Ertas, Mustafa; Gulsen, Yesim; Baykan Baykal, Betul; MATUR, ZELİHAIntroduction: Migraine and temporomandibular disorders (TMD) are both common diseases and TMD are reported as a risk factor in migraine progression. OnabotulinumtoxinA is used in the treatment of chronic migraine (CM), and also has a potential role in TMD treatment. In this study, it is aimed to compare the efficacy of onabotulinumtoxinA treatment in CM patients with and without TMD.Publication Metadata only Increased photosensitivity following short sleep in sleep deprived patients(2017-06-01T00:00:00Z) Elmali, Ayse Deniz; Kurucu, Hatice; Cetin, Ozdem Erturk; Cokar, Ozlem; Matur, ZELİHA; Dervent, Aysin; BENBİR ŞENEL, GÜLÇİN; Gurses, Candan; Demirbilek, Veysi; MATUR, ZELİHAIntroduction. We aimed to determine the effect of short day-time sleep on photoparoxysmal epileptic activity in sleep-deprived patients.Publication Metadata only Neurogenic heterotopic ossification in Guillain-Barre syndrome: a rare case report(2020-03-01T00:00:00Z) Nalbantoglu, Mecbure; Tuncer, Ozlem Gungor; Acik, M. Eren; Matur, ZELİHA; Altunrende, Burcu; Ozgonenel, Ebru; Ozgonenel, Levent; MATUR, ZELİHANeurogenic heterotopic ossification (NHO) is an abnormal development of bone in extra-skeletal tissues, related to neurological disease. NHO is frequently seen after traumatic brain injury or spinal cord injury. NHO may also occur as a rare complication of Guillain Barre Syndrome (GBS). Here, we present a 39 year old man with an acute onset of GBS who developed NHO around both hips two months after the disease onset. Our patient had a history of mechanical ventilation, incomplete tetraplegia and prolonged immobilisation. The pathogenesis of NHO is unclear. Various risk factors have been associated with the development of NHO; prolonged coma, long-term sedation, spasticity, degree of paralysis. NHO is a rare complication of GBS and physicians should be aware that it can develop especially in patients with severe paralysis and in need of mechanical ventilation. Pain and restriction of movements, especially in the hips, should bring NHO to the mind.Publication Metadata only Electromyography in Pediatric Population(2018-03-01T00:00:00Z) KOCASOY ORHAN, Elif; Baysal Kirac, Leyla; YALİNAY DİKMEN, PİNAR; Matur, ZELİHA; Ertas, Mustafa; ÖGE, Ali Emre; Deymeer, Feza; Yazici, Jale; BASLO, Mehmet Barış; MATUR, ZELİHAIntroduction: Electrodiagnostic evaluation provides an important extension to the neurological examination for the evaluation of pediatric neuromuscular disease. Many pediatric neuromuscular diseases are analogous to those seen in the adult. However, the relative frequency of these illnesses varies greatly when different age populations are compared. The purpose of the present study is to provide a retrospective analysis of children referred to our electromyography (EMG) laboratory for electrophysiological examinations.Publication Metadata only Exonic duplication CNV of NDRG1 associated with autosomal-recessive HMSN-Lom/CMT4D(2014-05-01T00:00:00Z) Okamoto, Yuji; Goksungur, Meryem Tuba; Pehlivan, Davut; Beck, Christine R.; Gonzaga-Jauregui, Claudia; Muzny, Donna M.; Atik, Mehmed M.; Carvalho, Claudia M. B.; Matur, ZELİHA; BAYRAKTAR, Şerife; Boone, Philip M.; Akyuz, Kaya; Gibbs, Richard A.; Battaloglu, Esra; Parman, Yesim; Lupski, James R.; MATUR, ZELİHAPurpose: Copy-number variations as a mutational mechanism contribute significantly to human disease. Approximately one-half of the patients with Charcot-Marie-Tooth (CMT) disease have a 1.4Mb duplication copy-number variation as the cause of their neuropathy. However, non-CMTIA neuropathy patients rarely have causative copy-number variations, and to date, autosomal-recessive CMT disease has not been associated with copy-number Variation as a mutational mechanism.Publication Metadata only Evaluation of neurological examination, SEP results, MRI results, and lesion levels in patients who had been operated for myelomeningocele(2020-10-01T00:00:00Z) Canaz, Gokhan; Canaz, Huseyin; Erdogan, Ezgi T.; Alatas, Ibrahim; Emel, Erhan; Matur, ZELİHA; MATUR, ZELİHAObjective: Myelomeningocele is the most severe and the most frequent form of spina bifida. Most of the myelomeningocele patients undergo operations in new-born age. In terms of life quality and rehabilitation, follow-up-s of these patients in the growth and development period after the operation is critical. In our study, our aim is to emphasize the correlation of SEP results with MRI results and clinical features of the myelomeningocele patients. Materials and Methods: In our study, we included 36 patients who had undergone myelomeningocele operation and have been followed-up in Istanbul Bilim University Florence Nightingale Hospital, Spina Bifida Research and Treatment Centre. Posterior tibial nerve SEP was performed on each patient and neurological examinations were done in the same session. Results were compared with clinical functional lesion levels, levels of fusion defect and ambulation levels. In order to evaluate SEP results, we used age-related reference values from Boor et al.-s study in 2008. Patients were grouped as normal, unilaterally prolonged, bilaterally prolonged, unilaterally lost, and bilaterally lost. Results: The correlations of posterior tibial nerve SEP results were significant with ambulation levels (r = 0.428, P < 0.01), clinical functional lesion levels (r = 0.477, P < 0.01) and fusion defect levels (r = -0.528 P < 0.05). The lumbar SEP results were only significantly correlated with functional lesion levels (r = 0.443 P < 0.05). Conclusions: Radiological studies are insufficient when evaluating the functionality of the central nervous system. To fully evaluate the functionality and watch the neurological development with accuracy, especially in operated patients, electrophysiological studies should be an indispensable part of myelomeningocele follow-ups.Publication Metadata only Genotypic and phenotypic presentation of transthyretin-related familial amyloid polyneuropathy (TTR-FAP) in Turkey(2016-07-01T00:00:00Z) Durmus-Tekce, Hacer; Matur, ZELİHA; Atmaca, Murat Mert; PODA, Mehveş; ÇAKAR, Arman; Ulas, Umit Hidir; Oflazer-Serdaroglu, Piraye; Deymeer, Feza; Parman, Yesim G.; MATUR, ZELİHATransthyretin-related familial amyloid polyneuropathy (TTR-FAP) is an autosomal dominant disorder caused by mutations of the transthyretin (TTR) gene. The mutant amyloidogenic transthyretin protein causes the systemic accumulation of amyloid fibrils that result in organ dysfunction. TTR-associated FAP is a progressive and fatal disease, if left untreated, and should be considered in the differential diagnosis of any person presenting with a progressive polyneuropathy, particularly with accompanying autonomic involvement. The clinical, electrophysiological, histopathological, and genetic characteristics of 17 patients from Turkey (5 female, 13 male) from nine families with polyneuropathy and mutations in TTR were evaluated. Sequence analysis of the TTR gene revealed five mutations (Va130Met, Glu89Gln, Gly53Glu, Glu54Gly and Gly47Glu). Mean age at disease onset was 40.4 +/- 13.9 years (range 21-66 years). The most commonly reported initial complaint was paresthesia in the feet (asymmetric in three patients). Three patients (2 male) with the Glu89Gln mutation presented with carpal tunnel syndrome. Two patients with the Gly53Glu mutation showed episodes of dysarthria and hemiparesis, consistent with this genotype. Seven patients died during the period of follow-up as a result of systemic involvement. Our study suggests that a cohort of patients from Turkey with TTR-FAP exhibits clinical and genetic heterogeneity. (C) 2016 Elsevier B.V. All rights reserved.
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