Person: MATUR, ZELİHA
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Publication Metadata only Somatosensory Evoked Potentials In Patients With Juvenile Myoclonic Epilepsy(2016-01-01T00:00:00Z) Ozemir, Zeynep Aydin; Matur, ZELİHA; BAYKAL, Betül; ÖGE, Ali Emre; MATUR, ZELİHAWhile a small number of studies dealing with somatosensory evoked potential (SEP) have demonstrated hyperexcitability in the primary somatosensory cortex of juve-nile myoclonic epilepsy (JME) patients, the underlying mechanisms have yet to be illuminated. Determination of higher cortical SEP responses in some JME patients and recordings of very high amplitude responses, called -giant SEP,- in a specific subgroup may indicate a clinical and possibly genetic heterogeneity within JME patients. In the present review, the findings of previous studies concerned with SEP in JME patients are summarized, and their importance regarding JME etiopathogenesis and related clinical findings is discussed.Publication Metadata only Clinical, Electrophysiological, and Serological Evaluation of Patients with Cramp-Fasciculation Syndrome(2017-06-01T00:00:00Z) Poyraz, Muruvvet; Matur, ZELİHA; Aysal, Fikret; TÜZÜN, Erdem; Hanoglu, Lutfu; ÖGE, Ali Emre; MATUR, ZELİHAIntroduction: Cramp-fasciculation syndrome (CFS) is a rare peripheral nerve hyperexcitability syndrome. There are only a few reports on clinical and serological profile of a CFS cohort that was followed up by a single outpatient clinic.Publication Metadata only Evaluation of OnabotulinumtoxinA Treatment in Patients with Concomitant Chronic Migraine and Temporomandibular Disorders(2018-12-01T00:00:00Z) Kocaman, Gulsen; Kahraman, Nese; Gurkan Koseoglu, Banu; Bilgic, Basar; Ertas, Mustafa; Gulsen, Yesim; Baykan Baykal, Betul; MATUR, ZELİHAIntroduction: Migraine and temporomandibular disorders (TMD) are both common diseases and TMD are reported as a risk factor in migraine progression. OnabotulinumtoxinA is used in the treatment of chronic migraine (CM), and also has a potential role in TMD treatment. In this study, it is aimed to compare the efficacy of onabotulinumtoxinA treatment in CM patients with and without TMD.Publication Metadata only Increased photosensitivity following short sleep in sleep deprived patients(2017-06-01T00:00:00Z) Elmali, Ayse Deniz; Kurucu, Hatice; Cetin, Ozdem Erturk; Cokar, Ozlem; Matur, ZELİHA; Dervent, Aysin; BENBİR ŞENEL, GÜLÇİN; Gurses, Candan; Demirbilek, Veysi; MATUR, ZELİHAIntroduction. We aimed to determine the effect of short day-time sleep on photoparoxysmal epileptic activity in sleep-deprived patients.Publication Metadata only Electromyography in Pediatric Population(2018-03-01T00:00:00Z) KOCASOY ORHAN, Elif; Baysal Kirac, Leyla; YALİNAY DİKMEN, PİNAR; Matur, ZELİHA; Ertas, Mustafa; ÖGE, Ali Emre; Deymeer, Feza; Yazici, Jale; BASLO, Mehmet Barış; MATUR, ZELİHAIntroduction: Electrodiagnostic evaluation provides an important extension to the neurological examination for the evaluation of pediatric neuromuscular disease. Many pediatric neuromuscular diseases are analogous to those seen in the adult. However, the relative frequency of these illnesses varies greatly when different age populations are compared. The purpose of the present study is to provide a retrospective analysis of children referred to our electromyography (EMG) laboratory for electrophysiological examinations.Publication Metadata only Exonic duplication CNV of NDRG1 associated with autosomal-recessive HMSN-Lom/CMT4D(2014-05-01T00:00:00Z) Okamoto, Yuji; Goksungur, Meryem Tuba; Pehlivan, Davut; Beck, Christine R.; Gonzaga-Jauregui, Claudia; Muzny, Donna M.; Atik, Mehmed M.; Carvalho, Claudia M. B.; Matur, ZELİHA; BAYRAKTAR, Şerife; Boone, Philip M.; Akyuz, Kaya; Gibbs, Richard A.; Battaloglu, Esra; Parman, Yesim; Lupski, James R.; MATUR, ZELİHAPurpose: Copy-number variations as a mutational mechanism contribute significantly to human disease. Approximately one-half of the patients with Charcot-Marie-Tooth (CMT) disease have a 1.4Mb duplication copy-number variation as the cause of their neuropathy. However, non-CMTIA neuropathy patients rarely have causative copy-number variations, and to date, autosomal-recessive CMT disease has not been associated with copy-number Variation as a mutational mechanism.Publication Metadata only Genotypic and phenotypic presentation of transthyretin-related familial amyloid polyneuropathy (TTR-FAP) in Turkey(2016-07-01T00:00:00Z) Durmus-Tekce, Hacer; Matur, ZELİHA; Atmaca, Murat Mert; PODA, Mehveş; ÇAKAR, Arman; Ulas, Umit Hidir; Oflazer-Serdaroglu, Piraye; Deymeer, Feza; Parman, Yesim G.; MATUR, ZELİHATransthyretin-related familial amyloid polyneuropathy (TTR-FAP) is an autosomal dominant disorder caused by mutations of the transthyretin (TTR) gene. The mutant amyloidogenic transthyretin protein causes the systemic accumulation of amyloid fibrils that result in organ dysfunction. TTR-associated FAP is a progressive and fatal disease, if left untreated, and should be considered in the differential diagnosis of any person presenting with a progressive polyneuropathy, particularly with accompanying autonomic involvement. The clinical, electrophysiological, histopathological, and genetic characteristics of 17 patients from Turkey (5 female, 13 male) from nine families with polyneuropathy and mutations in TTR were evaluated. Sequence analysis of the TTR gene revealed five mutations (Va130Met, Glu89Gln, Gly53Glu, Glu54Gly and Gly47Glu). Mean age at disease onset was 40.4 +/- 13.9 years (range 21-66 years). The most commonly reported initial complaint was paresthesia in the feet (asymmetric in three patients). Three patients (2 male) with the Glu89Gln mutation presented with carpal tunnel syndrome. Two patients with the Gly53Glu mutation showed episodes of dysarthria and hemiparesis, consistent with this genotype. Seven patients died during the period of follow-up as a result of systemic involvement. Our study suggests that a cohort of patients from Turkey with TTR-FAP exhibits clinical and genetic heterogeneity. (C) 2016 Elsevier B.V. All rights reserved.Publication Metadata only Erratum: Evaluation of OnabotulinumtoxinA Treatment in Patients with Concomitant Chronic Migraine and Temporomandibular Disorders.(2019-03-01T00:00:00Z) Kocaman, Gülşen; Kahraman, Neşe; Köseoğlu, Banu Gürkan; Bilgiç, Başar; Matur, ZELİHA; Ertaş, Mustafa; Gülşen, Yeşim; Baykan, Betul; MATUR, ZELİHAPublication Metadata only Genotypic and phenotypic presentation of TTR-FAP in Turkey(2016-06-01T00:00:00Z) Durmus, H.; Cakar, A.; Atmaca, M. M.; Matur, ZELİHA; Altunoglu, U.; PODA, Mehveş; Ulas, U. H.; Oflazer, P.; Deymeer, F.; Parman, Y.; MATUR, ZELİHAPublication Metadata only The Impact of Affective State on Quality of Life in Focal Epilepsy in Turkey(2019-04-01T00:00:00Z) TAŞKIRAN, EMİNE; Matur, ZELİHA; Gul, Gunay; BEBEK, Nerses; BAYKAL, Betül; Gokyigit, Aysen; Gurses, Candan; MATUR, ZELİHAContext: Seizures and accompanying situations including social, medical, and psychiatric problems threaten the quality of life (QOL) in patients with epilepsy. The World Health Organization defines health is a state of complete physical, mental, and social well-being, and not merely the absence of disease or infirmity. Aims: This study examines the prevalence of both depression and anxiety symptoms and also impact of the affective state on QOL in patients with focal epilepsy in Turkey. Settings and Design: One hundred and five patients with focal epilepsy over 18 years old were included in this study. The patients were classified into four groups according to the presence of AS and seizure control. Subjects and Methods: Patients- affective symptoms (AS) and QOL were examined using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and QOL in Epilepsy Inventory-31 (QOLIE-31). Statistical Analysis Used: We used descriptive statistics, Chi-square test, independent samples t-test, one-way analysis of variance, Mann-Whitney U-test, Kruskal-Wallis H-test, and also Pearson-s and Spearman-s correlation test for correlations. Results: There were positive correlations between total QOLIE-31 score and epilepsy surgery, employment, and seizure freedom, whereas negative correlations were found with antiepileptic drug use, anxiety, and depression. Statistically significant differences were found in QOLIE-31 totals and subscores between Groups 3 and 4 (P < 0.05). Conclusions: The presence of AS has a negative impact on QOL in patients with focal epilepsy. Physicians should be aware that psychiatric comorbidities in epilepsy have a severe impact and epilepsy treatment requires comprehensive management.