Person: AKÇAKAYA, ADEM
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Publication Metadata only Evaluation of Parathyroid allo-transplantation with the Presence of Auto-CASR Antibody(2022-05-01) Selepcioğlu Kaya H.; Göncü B. S.; Ersoy Y. E.; Akçakaya A.; SELEPCİOĞLU KAYA, HARİKA; GÖNCÜ, BEYZA SERVET; ERSOY, YELIZ EMINE; AKÇAKAYA, ADEMPublication Metadata only EDITORIAL(2022-07-01) Akçakaya A.; AKÇAKAYA, ADEMPublication Open Access EDITORIAL(2022-04-01) Akçakaya A.; AKÇAKAYA, ADEMPublication Open Access EDITORIAL(2021-09-01) Akçakaya A.; AKÇAKAYA, ADEMPublication Open Access Editorial(2022-04-01) Akçakaya A.; AKÇAKAYA, ADEMPublication Open Access EDITORIAL(2022-04-01) Akçakaya A.; AKÇAKAYA, ADEMPublication Metadata only The Challenge of Preoperative Panel Reactive Antibody Positivity in Parathyroid Transplantation(2024-02-01) Göncü B. S.; Yücesan E.; Selepcioğlu Kaya H.; Kazancıoğlu R.; Ersoy Y. E.; Akçakaya A.; GÖNCÜ, BEYZA SERVET; SELEPCİOĞLU KAYA, HARİKA; KAZANCIOĞLU, RÜMEYZA; ERSOY, YELIZ EMINE; AKÇAKAYA, ADEMPublication Metadata only An Alternative and Up-To-Date Recommendation for a Proper Site for Parathyroid Transplantation: The Omentum(2024-02-01) Ersoy Y. E.; Göncü B. S.; Yücesan E.; Selepcioğlu Kaya H.; Kazancıoğlu R.; Akçakaya A.; ERSOY, YELIZ EMINE; GÖNCÜ, BEYZA SERVET; SELEPCİOĞLU KAYA, HARİKA; KAZANCIOĞLU, RÜMEYZA; AKÇAKAYA, ADEMObjectives: Various sites have been used for parathyroid allotransplant, such as injection into the forearm, sternocleidomastoid, or deltoid muscles. However, transplant efficiency in these regions varies according to the results reported in the literature and also obtained from our previous studies. Using the omentum "as a natural incubator" for composite tissue-derived cell transplants to increase transplant success is possible. Materials and methods: To examine the efficiency of transplant sites for parathyroid allotransplant, we compared clinical cases from the literature and our experience with 23 cases. The omental transplant process is performed under general anesthesia by laparoscopic intervention. The abdominal cavity is visualized with an endocamera from a 5-mm trocar. With the help of a flexible catheter from another 5-mm trocar, microencapsulated or naked parathyroid cells are deposited on the omentum in approximately 30 mL of isotonic saline. The trocar sites are then sutured, and the surgery is terminated. Recipients were followed for 6 months with examination of biochemical parameters (parathormone, calcium, and phosphorus levels), medication use, and clinical scoring. Results: In the 23 patients who received parathyroid allotransplants over the omentum, 7 recipients did not exhibit any changes according to the scoring system criteria. However, on average, serum calcium and phosphorus levels remained within the healthy reference range. In addition, use of oral medications among patients decreased, indicating successful transplant survival. These results were consistent with a significant decrease in hypocalcemia symptoms among patients. Conclusions: In the 23 patients, the success rate was 69.5% for the first 6-month period after transplant. Recent developments and large cohorts are needed to demonstrate the higher efficacy of parathyroid allotransplant over the omentum.Publication Open Access Phytotherapy in Obesity: Is It Necessary to Have Surgery?(2024-10-01) AKÇAKAYA A.; AKÇAKAYA, ADEMThe prevalence of obesity, which is defined by the World Health Organization as abnormal or excessive fat accumulation in the body that impairs health, is increasing day by day. In addition to behavioral therapy aimed at changing the individual\"s lifestyle based on the strategies developed against the disease, diet therapy, exercise, medical nutrition therapy, pharmacological and, as a last resort, surgical treatment are recommended. The effect of methods other than surgical treatment on weight loss is slow. For this reason, many obese patients prefer obesity surgery to lose weight quickly, but these methods have many complications such as weight regain, tachycardia, fistula, bleeding, herniation, anastomotic stenosis, gastric erosion, small bowel obstructions, deep vein thrombosis and pulmonary embolism. Post-surgical weight regain and complications have recently led to new searches, and the use of medical nutrition and phytotherapy products has again come to the fore as hope. Phytotherapy products can also be used alone or in combination with other methods. Natural anti-obesity products have functional ingredients such as phytochemicals, polyphenols, flavonoids and phytosterols. There are many natural products used in this field and therefore there are different classifications. Phytotherapeutics are classified according to their effectiveness as those that increase fat burning and stimulate metabolism, suppress appetite, create a feeling of satiety, control blood sugar and insulin, inhibit the absorption of carbohydrates and fats, and inhibit inflammation. However, more clinical research is needed to elucidate the antiobesity effectiveness and mechanism of action of natural products. The risks and side effects of the method to be chosen in obesity treatment should be discussed with the patient. Recommendations to the patient should be given after a multidisciplinary evaluation. Treatment should be started with the most appropriate and least risky method for the patient\"s current condition. It should be explained to the patient that it is most likely that he/she will lose weight with one of these methods, but that the important thing is to maintain his/her weight through behavioral changes.