2017-01-01, Koker, Ibrahim Hakki, Aralasmak, AYŞE, Unver, NURCAN, Asil, TALİP, Senturk, HAKAN, KÖKER, İBRAHİM HAKKI, ARALAŞMAK, AYŞE, ÜNVER, NURCAN, ASİL, TALIP, ŞENTÜRK, HAKAN

Introduction: Endosonography guided celiac plexus neurolysis is efficacious in the management of severe pain due to advanced pancreatic cancer. Although endoscopic ultrasound (EUS) guided celiac neurolysis (CN) is mostly a safer procedure than the percutaneous posterior approach, severe complications such as paraplegia have been reported.

2012-01-01T00:00:00Z, Soylu, Ali Riza, Tuglu, Cengiz, Arikan, Ender, Yetisyigit, Tarkan, Kunduracilar, Hakan, Koker, Ibrahim Hakki, Unsal, Gulbin, Tezel, Ahmet Huseyin, Umit, Hasan, Berkarda, Sakir, KÖKER, İBRAHİM HAKKI

Objective. In this study, we aimed to investigate the possible role of serum cytokines in the development of hepatic osteodystrophy. Matherial and Methods. 44 consecutive male cirrhotic patients (17 alcoholic, 20 hepatitis B, 7 hepatitis C), 15 age- and sex-matched chronic alcoholics without liver disease, and 17 age- and sex-matched healthy controls were included in the study during one year period. Bone mineral density was measured by dual X-ray absorptiometry in the lumbar vertebrate and femoral neck. Serum interleukin levels were measured by ELISA method. Results. Although osteopenia frequency between our cirrhotic patients was 20%, there was no difference in T-scores among the controls and other groups. Serum interleukin-1, interleukin-8, and tumor necrosis factor-alpha levels were not different between all groups. Serum interleukin-2 and interleukin-6 levels were higher in the cirrhotics than controls (P < 0.001). However, there were no significant difference between osteopenic and nonosteopenic cirrhotics. Conclusion. According to the results of the study in this small population of 44 male cirrhotic patients, frequency of hepatic osteopenia is small and serum interleukins 1, 2, 6, 8, and tumor necrosis factor-alpha may not play a role in the pathogenesis of hepatic osteodystrophy. Further studies in which large number of patients involved are necessary in this field.

2012-06-01T00:00:00Z, Bugdaci, Mehmet Sait, Oztekin, Erkan, Kara, Ekrem, Koker, Ibrahim, Tufan, Ayhan, KÖKER, İBRAHİM HAKKI

Background: Acute pancreatitis (AP) is a systemic disease with a rising incidence. Cardiac dysfunction may occur as an early complication of AP. B type natriuretic factor (BNP) is a diagnostic and prognostic indicator of cardiac disorders. Therefore, in this study we aimed to assess the relationship between serum BNP concentrations and severity of AP.

2019-06-01T00:00:00Z, Koçhan, K, Şentürk, H, Köker, İH, Gülen, B, İnce, ALİ TÜZÜN, BİBERCİ KESKİN, ELMAS, KOÇHAN, KORAY, KÖKER, İBRAHİM HAKKI, İNCE, ALİ TÜZÜN, ŞENTÜRK, HAKAN

Background Hypertriglyceridemia (HTG)-induced acute pancreatitis (AP) leads to higher morbidity and mortality compared with other etiologies. The role of plasma exchange (PE) in this context is still not well established. We aimed to assess the clinical outcomes of patients with HTG-induced AP who underwent PE and compare it with those who did not. Patients and methods We retrospectively evaluated the data of patients who were admitted with HTG-induced AP between January 2013 and May 2018. The endpoint of the study was to assess the clinical outcomes, which included complication rates, mortality, and pancreatitis recurrence rate. Results Overall, 41 patients were included in the final analysis. Of these, 12 (29.2%) underwent PE. Patients undergoing PE had more severe pancreatitis on the basis of the Japanese Severity Score [10 (83.3%) vs. 14 (48.3%), P=0.03, respectively). Although mortality was higher in patients who underwent PE [three (25.0%) vs. zero, P<0.01, respectively], there was no difference in terms of complications and recurrence rates. Over a median 21 months of follow-up, 11 (26.8%) patients had recurrent AP. Conclusion Although PE effectively reduced plasma triglyceride levels, there was no decrease in mortality or recurrences.

2020-10-05T00:00:00Z, Senturk, Hakan, Seven, GÜLSEREN, Kochan, KORAY, Caglar, Erkan, Kiremitci, Sercan, Koker, Ibrahim Hakki, SEVEN, GÜLSEREN, KOÇHAN, KORAY, KÖKER, İBRAHİM HAKKI, ŞENTÜRK, HAKAN

Background: The risk of malignancy in resected gastrointestinal stromal tumors (GISTs) depends on tumor size, location, and mitotic index. Reportedly, the Ki67 index has a prognostic value in resected GISTs. We aimed to analyze the accuracy of endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) samples with reference to Ki67 index, using surgical specimens as the gold standard. Methods: Fifty-five patients who underwent EUS-FNA followed by surgical resection for gastric GISTs were retrospectively analyzed. Patients’ age and sex; tumors’ size and location; mitotic index, cell type, cellularity, pleomorphism, presence of ulceration, hemorrhage, necrosis, mucosal or serosal invasion, growth pattern, and Ki67 index based on pathology were investigated. Results: Location in fundus, ulceration, hemorrhage, mucosal invasion, and Ki67 index in surgical specimens were significant in predicting high-risk groups (P < 0.05) on univariate analysis. resence of bleeding (P = 0.034) and the Ki67 index (P = 0.018) were the only independent significant factors in multivariate analysis. The optimal cutoff level of Ki67 was 5%, with 88.2% sensitivity and 52.8% specificity (P = 0.021). The mean Ki67 index was lower in EUS-FNA samples than in surgical specimens [2% (1-15) vs. 10% (1-70), P = 0.001]. The rank correlation coefficient value of Ki67 was 0.199 (P = 0.362) between EUS-FNA and surgical samples and showed no reliability for EUS-FNA samples. Conclusion: The Ki67 index in resected specimens correlated with high-risk GISTs, although it had no additive value to the current criteria. The Ki67 index in EUS-guided FNA samples is not a reliable marker of proliferation in GISTs.

2020-01-01T00:00:00Z, Medetalibeyoglu, Alpay, Celik, Seda, Deniz, Rabia, Caparali, Emine Bilge, Kose, Murat, Akpinar, Timur Selcuk, Arman, Yucel, Atici, Adem, Akarsu, Murat, Yoldemir, Sengul Aydin, KÖKER, İBRAHİM HAKKI, Tukek, Tufan, KÖKER, İBRAHİM HAKKI

Objective: The aim of this study is to investigate the role of sTREM-1 molecule in the diagnosis of spontaneous bacterial peritonitis in patients with portal type ascites.

2015-07-01T00:00:00Z, Koker, Ibrahim Hakki, KÖKER, İBRAHİM HAKKI

2016-01-01T00:00:00Z, Koker, Ibrahim Hakki, KÖKER, İBRAHİM HAKKI

2021-08-01T00:00:00Z, KÖKER, İBRAHİM HAKKI, ŞAHİN, NURHAN, KÖKER, İBRAHİM HAKKI, ŞAHİN, NURHAN

2019-05-01, biberci keskin, elmas, Sümbül Gültepe, Bilge, Köker, ibrahim Hakkı, Şentürk, HAKAN, BİBERCİ KESKİN, ELMAS, İNCE, ALİ TÜZÜN, KÖKER, İBRAHİM HAKKI, ŞENTÜRK, HAKAN