Person: KÖKER, İBRAHİM HAKKI
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Publication Metadata only Spinal cord ischemia after endoscopic ultrasound guided celiac plexus neurolysis: case report and review of the literature(2017-01-01) Koker, Ibrahim Hakki; Aralasmak, AYŞE; Unver, NURCAN; Asil, TALİP; Senturk, HAKAN; KÖKER, İBRAHİM HAKKI; ARALAŞMAK, AYŞE; ÜNVER, NURCAN; ASİL, TALIP; ŞENTÜRK, HAKANIntroduction: Endosonography guided celiac plexus neurolysis is efficacious in the management of severe pain due to advanced pancreatic cancer. Although endoscopic ultrasound (EUS) guided celiac neurolysis (CN) is mostly a safer procedure than the percutaneous posterior approach, severe complications such as paraplegia have been reported.Publication Metadata only Evaluation of Ki67 index in endoscopic ultrasound-guided fine needle aspiration samples for the assessment of malignancy risk in gastric gastrointestinal stromal tumors.(2020-10-05T00:00:00Z) Senturk, Hakan; Seven, GÜLSEREN; Kochan, KORAY; Caglar, Erkan; Kiremitci, Sercan; Koker, Ibrahim Hakki; SEVEN, GÜLSEREN; KOÇHAN, KORAY; KÖKER, İBRAHİM HAKKI; ŞENTÜRK, HAKANBackground: The risk of malignancy in resected gastrointestinal stromal tumors (GISTs) depends on tumor size, location, and mitotic index. Reportedly, the Ki67 index has a prognostic value in resected GISTs. We aimed to analyze the accuracy of endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) samples with reference to Ki67 index, using surgical specimens as the gold standard. Methods: Fifty-five patients who underwent EUS-FNA followed by surgical resection for gastric GISTs were retrospectively analyzed. Patients’ age and sex; tumors’ size and location; mitotic index, cell type, cellularity, pleomorphism, presence of ulceration, hemorrhage, necrosis, mucosal or serosal invasion, growth pattern, and Ki67 index based on pathology were investigated. Results: Location in fundus, ulceration, hemorrhage, mucosal invasion, and Ki67 index in surgical specimens were significant in predicting high-risk groups (P < 0.05) on univariate analysis. resence of bleeding (P = 0.034) and the Ki67 index (P = 0.018) were the only independent significant factors in multivariate analysis. The optimal cutoff level of Ki67 was 5%, with 88.2% sensitivity and 52.8% specificity (P = 0.021). The mean Ki67 index was lower in EUS-FNA samples than in surgical specimens [2% (1-15) vs. 10% (1-70), P = 0.001]. The rank correlation coefficient value of Ki67 was 0.199 (P = 0.362) between EUS-FNA and surgical samples and showed no reliability for EUS-FNA samples. Conclusion: The Ki67 index in resected specimens correlated with high-risk GISTs, although it had no additive value to the current criteria. The Ki67 index in EUS-guided FNA samples is not a reliable marker of proliferation in GISTs.Publication Metadata only Patient selection bias and inappropriate stent selection leading to false conclusions in the comparison of metal and plastic stents(2016-01-01T00:00:00Z) Koker, Ibrahim Hakki; KÖKER, İBRAHİM HAKKIPublication Metadata only The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients(2012-01-01T00:00:00Z) Soylu, Ali Riza; Tuglu, Cengiz; Arikan, Ender; Yetisyigit, Tarkan; Kunduracilar, Hakan; Koker, Ibrahim Hakki; Unsal, Gulbin; Tezel, Ahmet Huseyin; Umit, Hasan; Berkarda, Sakir; KÖKER, İBRAHİM HAKKIObjective. In this study, we aimed to investigate the possible role of serum cytokines in the development of hepatic osteodystrophy. Matherial and Methods. 44 consecutive male cirrhotic patients (17 alcoholic, 20 hepatitis B, 7 hepatitis C), 15 age- and sex-matched chronic alcoholics without liver disease, and 17 age- and sex-matched healthy controls were included in the study during one year period. Bone mineral density was measured by dual X-ray absorptiometry in the lumbar vertebrate and femoral neck. Serum interleukin levels were measured by ELISA method. Results. Although osteopenia frequency between our cirrhotic patients was 20%, there was no difference in T-scores among the controls and other groups. Serum interleukin-1, interleukin-8, and tumor necrosis factor-alpha levels were not different between all groups. Serum interleukin-2 and interleukin-6 levels were higher in the cirrhotics than controls (P < 0.001). However, there were no significant difference between osteopenic and nonosteopenic cirrhotics. Conclusion. According to the results of the study in this small population of 44 male cirrhotic patients, frequency of hepatic osteopenia is small and serum interleukins 1, 2, 6, 8, and tumor necrosis factor-alpha may not play a role in the pathogenesis of hepatic osteodystrophy. Further studies in which large number of patients involved are necessary in this field.Publication Metadata only Importance of ascites adenosine deaminase in diagnosing abdominal tuberculosis with ascites(2015-07-01T00:00:00Z) Koker, Ibrahim Hakki; KÖKER, İBRAHİM HAKKIPublication Metadata only The largest colorectal polyp cohort study in Turkey: Should more details be evaluated?(2014-10-01T00:00:00Z) Koker, Ibrahim Hakki; KÖKER, İBRAHİM HAKKI