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GAZİOĞLU, IŞIL

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IŞIL
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GAZİOĞLU
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2020 - 20226
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Type: Article × Start date: 2020 × End date: 2022 ×

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Now showing 1 - 6 of 6
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    PublicationOpen Access
    Triterpenoids and steroids isolated from Anatolian Capparis ovata and their activity on the expression of inflammatory cytokines
    (2020-01-01T00:00:00Z) GAZİOĞLU, IŞIL; Semen, Sevcan; Acar, Ozden Ozgun; KOLAK, Ufuk; Sen, Alaattin; TOPÇU, GÜLAÇTI; GAZİOĞLU, IŞIL; TOPÇU, GÜLAÇTI
    Context: Capparis L. (Capparaceae) is grown worldwide. Caper has been used in traditional medicine to treat various diseases including rheumatism, kidney, liver, stomach, as well as headache and toothache. Objective: To isolate and elucidate of the secondary metabolites of the C. ovata extracts which are responsible for their anti-inflammatory activities. Materials and methods: Buds, fruits, flowers, leaves and stems of C. ovata Desf. was dried, cut to pieces, then ground separately. From their dichloromethane/hexane (1:1) extracts, eight compounds were isolated and their structures were elucidated by NMR, mass spectroscopic techniques. The effects of compounds on the expression of inflammatory cytokines in SH-SY5Y cell lines were examined by qRT-PCR ranging from 4 to 96 mM. Cell viability was expressed as a percentage of the control, untreated cells. Results: This is a first report on isolation of triterpenoids and steroids from C. ovata with anti-inflammatory activity. One new triterpenoid ester olean-12-en-3b,28-diol, 3b-pentacosanoate (1) and two new natural steroids 5a,6a-epoxycholestan-3b-ol (5) and 5b,6b-epoxycholestan-3b-ol (6) were elucidated besides known compounds; oleanolic acid (2), ursolic acid (3), b-sitosterol (4), stigmast-5,22-dien-3b-myristate (7) and bismethyl-octylphthalate (8). mRNA expression levels as EC10 of all the tested seven genes were decreased, particularly CXCL9 (19.36-fold), CXCL10 (8.14-fold), and TNF (18.69) by the treatment of 26 mM of compound 1 on SH-SY5Y cells. Discussion and conclusions: Triterpenoids and steroids isolated from C. ovata were found to be moderate-strong anti-inflammatory compounds. Particularly, compounds 1 and 3 were found to be promising therapeutic agents in the treatment of inflammatory and autoimmune diseases.
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    Determination of Polycyclic Aromatic Hydrocarbons in Nutritional Supplements by Fabric Phase Sorptive Extraction (FPSE) with High-Performance Liquid Chromatography (HPLC) with Fluorescence Detection
    (2020-01-01T00:00:00Z) GAZİOĞLU, IŞIL; Zengin, Ozge Sultan; Tartaglia, Angela; Locatelli, Marcello; Furton, Kenneth G.; Kabir, Abuzar; GAZİOĞLU, IŞIL
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    PublicationOpen Access
    Remineralization potential of P11-4 and fluoride on secondary carious primary enamel: A quantitative evaluation using microcomputed tomography.
    (2022-01-04T00:00:00Z) Gazioğlu, IŞIL; Taran, Pınar Kınay; Mammadlı, Narmin; Altınova, İlay Sena; ÖZDEMİR, ŞERİFE; ALTINOVA, İLAY SENA; GAZİOĞLU, IŞIL
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    Development of sol-gel phenyl/methyl/poly (dimethylsiloxane) sorbent coating for fabric phase sorptive extraction and its application in monitoring human exposure to selected polycyclic aromatic hydrocarbons using high performance liquid chromatography-fluorescence detection
    (2021-01-01T00:00:00Z) GAZİOĞLU, IŞIL; Kabir, Abuzar; Zengin, Ozge S.; Tekkeli, Evrim Kepekci; Furton, Kenneth G.; Tartaglia, Angela; Locatelli, Marcello; GAZİOĞLU, IŞIL; TEKKELİ, ŞERİFE EVRİM
    Following the convenient, yet very powerful pathway to create designer extraction sorbent using sol-gel chemistry, a novel sol-gel phenyl/methyl/poly(dimethylsiloxane) sorbent coating was created on polyester fabric substrate for fabric phase sorptive extraction (FPSE) and was subsequently applied to monitor human exposure to selected polycyclic aromatic hydrocarbons (PAHs) including pyrene, chrysene, and benzo[a]pyrene in plasma samples obtained from tobacco smoker volunteers using high performance liquid chromatography fluorescence detector (HPLC-FLD). A rapid FPSE-HPLC-FLD method was developed that adequately resolved the PAHs chromatographically, after their successful extraction from human plasma using fabric phase absorption extraction (FPSE) and subsequently analysed in the liquid chromatographic system by means of an analytical column (InterSustain C-18 column 150 x 4.6 mm, 5 mu m) using acetonitrile (ACN) and water as mobile phases in gradient elution mode. With the optimized conditions, the retention times were found to be 6.168, 7.214, and 10.404 min for pyrene, chrysene, and benzo[a]pyrene, respectively. The total chromatographic runtime was limited to 12.5 min.
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    Simultaneous determination of febuxostat and montelukast in human plasma using fabric phase sorptive extraction and high performance liquid chromatography-fluorimetric detection.
    (2021-12-05T00:00:00Z) Evrim Kepekci Tekkeli, S; Tartaglia, Angela; Aslan, Ceylin; Locatelli, Marcello; Kabir, Abuzar; GAZİOĞLU, IŞIL; TEKKELİ, ŞERİFE EVRİM
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    Spectrofluorimetric Determination of Aflatoxin B-1 in Winter Herbal Teas via Magnetic Solid Phase Extraction Method by using Metal-Organic Framework (MOF) Hybrid Structures Anchored with Magnetic Nanoparticles
    (2020-01-09T00:00:00Z) Durmus, Zehra; Kurt, BELMA; GAZİOĞLU, IŞIL; SEVGİ, ECE; Hancer, Cagla Kizilarslan; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA
    MIL53(Al)-SiO2@Fe3O4 composite was prepared by co-precipitation route with a typical Stober synthetic process and ultrasonic-agitation, then subsequently utilized as a multi-component novel sorbent in solid-phase microextraction (SPME) of aflatoxin B1 in winter herbal teas. Microstructural properties of MIL53(Al)-SiO2@Fe3O4 composite was characterized by using Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) methods, and Brunauer-Emmett-Teller (BET) surface area measurement. The MIL53(Al)-SiO2@Fe3O4 composite was found to be a very effective sorbent in spectrofluorimetric determination of aflatoxin B1 (AFB1) in winter herbal teas via magnetic solid-phase extraction (SPE) route. The proposed method showed a wide linear range from 0.5 to 150 ng/ml, low limit of detection (LOD = 0.5 ng/ml), and an acceptable recovery values (70.7-96.5%) in real samples analysis. This study shows that the suggested method possesses an important potential to use for detecting AFB1 in quality control laboratories.