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GAZİOĞLU, IŞIL

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Type: Article × Author: Hacibekiroglu, IŞIL ×

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Now showing 1 - 7 of 7
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    Effect of roasting on antioxidant and anticholinesterase capacities of coffee
    (2014-01-01) Yilmaz, Pelin Koseoglu; Hacibekiroglu, IŞIL; Kolak, Ufuk; GAZİOĞLU, IŞIL
    The aim of the study was to investigate the effect of the roasting degree on total phenolic and flavonoid contents, antioxidant and anticholinesterase activities of the hexane, acetone, ethanol and water extracts of coffee. The antioxidant capacity of the water extracts prepared according to the brewing procedure of Turkish coffee was measured for the first time by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and cupric ion reducing antioxidant capacity (CUPRAC) assays. The in vitro anticholinesterase activity of the coffee extracts and caffeine was determined for the first time. Water extracts of the coffee samples exhibited the highest 2,2--azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) cation radical scavenging, DPPH free radical scavenging and CUPRAC effects. The hexane extract of coffee roasted for 25 min showed the highest acetylcholinesterase inhibitory activity among the tested extracts. Caffeine, which is known to have therapeutic effect against Alzheimer-s disease, was found to possess almost the same anticholinesterase activity as galanthamine. The roasting degree had an irregular effect on the antioxidant and anticholinesterase activities of the coffee extracts. The caffeine contents in extracts of coffee roasted for 25 min, which had strong anticholinesterase effect, were determined by HPLC, and the water extract was found to possess the highest caffeine content.
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    Antioxidant and anticholinesterase activities of eleven edible plants
    (2011-03-01T00:00:00Z) Boga, Mehmet; Hacibekiroglu, IŞIL; Kolak, Ufuk; GAZİOĞLU, IŞIL
    Objective: The antioxidant potential and anticholinesterase activity of eleven edible plants were investigated.
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    Screening antioxidant and anticholinesterase potential of Iris albicans extracts
    (2015-03-01) Hacibekiroglu, IŞIL; Kolak, Ufuk; GAZİOĞLU, IŞIL
    The antioxidant and anticholinesterase activities of the extracts prepared from the rhizomes and flowering aerial parts of Iris albicans were determined in this study. The chloroform extract of the rhizomes was rich in total phenolic contents (431.98 +/- 0.49 mu gPEs/mg), and the chloroform extract of the aerial parts in total flavonoid contents (663.05 +/- 0.32 mu gQEs/mg). Although the chloroform extract of the rhizomes exhibited the best antioxidant effect in beta-carotene bleaching and CUPRAC methods among the tested extracts at all concentrations, it was found inactive in the metal chelating assay. The methanol extract of the aerial parts indicated moderate metal chelating activity (60%) at 100 mu g/mL. The chloroform extract of the rhizomes showed moderate anticholinesterase effect at 200 mu g/mL. The chloroform extract of the aerial parts showed significantly inhibition against butyrylcholinesterase (78.44 +/- 0.51%). (C) 2012 Production and hosting by Elsevier B. V. on behalf of King Saud University.
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    In vitro biological activities and fatty acid profiles of Pistacia terebinthus fruits and Pistacia khinjuk seeds
    (2015-03-04) Hacibekiroglu, IŞIL; Yilmaz, Pelin Koseoglu; Hasimi, Nesrin; Kilinc, Ersin; Tolan, Veysel; Kolak, Ufuk; GAZİOĞLU, IŞIL
    This study reports in vitro anticholinesterase, antioxidant and antimicrobial effects of the n-hexane, dichloromethane, ethanol and ethanol-water extracts prepared from Pistacia terebinthus L. fruits and Pistacia khinjuk Stocks seeds as well as their total phenolic and flavonoid contents, and fatty acid compositions. Ethanol and ethanol-water extracts of both species exhibited higher anticholinesterase activity than galanthamine. Among ABTS, DPPH and CUPRAC assays, the highest antioxidant capacity of the extracts was found in the last one. P. terebinthus ethanol extract being rich in flavonoid content showed the best cupric reducing effect. All extracts possessed no antimicrobial activity. The main fatty acid in P. terebinthus fruits (52.52%) and P. khinjuk seeds (59.44%) was found to be oleic acid. Our results indicate that P. terebinthus fruits and P. khinjuk seeds could be a good source of anticholinesterase compounds, and could be phytochemically investigated.
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    Antioxidant and Anticholinesterase Constituents from the Petroleum Ether and Chloroform Extracts of Iris suaveolens
    (2011-04-01T00:00:00Z) Hacibekiroglu, IŞIL; Kolak, Ufuk; GAZİOĞLU, IŞIL
    The aim of this study was to investigate the phytochemical, antioxidant and anticholinesterase activities of Iris suaveolens. After determining total phenolic and flavonoid contents of the petroleum ether, chloroform and methanol extracts prepared from the rhizomes, the antioxidant capacity of the extracts was established using beta-carotene-linoleic acid and CUPRAC methods. The chloroform extract which was rich in phenolic content exhibited the highest inhibition of lipid peroxidation in the beta-carotene-linoleic acid system, and the best cupric reducing antioxidant capacity among the tested extracts. The petroleum ether extract indicated moderate anticholinesterase activity while the chloroform extract revealed significant butyrylcholinesterase inhibitory activity (75.03 +/- 1.29%). Spectroscopic methods were used for the structural elucidation of the compounds (1-13) isolated from the petroleum ether and chloroform extracts. Coniferaldehyde (6), having the highest antioxidant activity in the beta-carotene-linoleic acid assay at 25 and 50 mu g/mL, demonstrated also the best effect in the CUPRAC method among the tested compounds (1-12). 3-Hydroxyirisquinone (10) showed the best anticholinesterase activity among the tested compounds (1-4, 6-12), and coniferaldehyde exhibited almost the same butyrylcholinesterase inhibitory activity (82.60 +/- 2.33%) as galantamine (86.26 +/- 0.66%). Copyright (C) 2010 John Wiley & Sons, Ltd.
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    Aflatoxins in various food from Istanbul, Turkey
    (2013-12-01) Hacibekiroglu, IŞIL; Kolak, U.; GAZİOĞLU, IŞIL
    The present work reports the total aflatoxin and aflatoxin B1 levels in 62 food samples from Istanbul, Turkey. The total aflatoxin content in dried American cucumber, squash, tomato, okra and saffron samples was found to be 1.7g/kg. AFB1 levels in five dried vegetables (red bell pepper, American cucumber, squash, tomato and okra), two tea (linden and jasmine flower) and three spice samples (cardamom, galangal and saffron) were 1g/kg. Of the tested samples, 76% exceeded legal limits of total aflatoxin. The highest levels were determined in chestnut (232.9g/kg), nutmeg (206.1g/kg) and sumac (182.5g/kg). These findings confirm the existing knowledge that food should be regularly and effectively controlled.
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    Phytochemical Investigation of Leontice leontopetalum L. subsp ewersmannii with Antioxidant and Anticholinesterase Activities
    (2011-01-01T00:00:00Z) Kolak, Ufuk; Hacibekiroglu, IŞIL; Boga, Mehmet; Özgökçe, Fevzi; Ünal, Murat; CHOUDHARY, M. Iqbal; Ulubelen, Ayhan; GAZİOĞLU, IŞIL
    Two known quinolizidine alkaloids, lupanine and leontiformidine, were isolated from the tubers of L. leontopetalum subsp. ewersmannii. Lupanine having the highest inhibition of lipid peroxidation at 100 mu g/mL among the tested samples indicated almost the same ABTS cation radical scavenging activity with BHT, alpha-tocopherol and (+)-catechin at the same concentration. Lupanine and the alkaloidal extract showed almost the same butyrylcholinesterase inhibitory activity with galantamine at 200 mu g/mL.