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GAZİOĞLU, IŞIL

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IŞIL
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Now showing 1 - 10 of 27
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    Effect of roasting on antioxidant and anticholinesterase capacities of coffee
    (2014-01-01) Yilmaz, Pelin Koseoglu; Hacibekiroglu, IŞIL; Kolak, Ufuk; GAZİOĞLU, IŞIL
    The aim of the study was to investigate the effect of the roasting degree on total phenolic and flavonoid contents, antioxidant and anticholinesterase activities of the hexane, acetone, ethanol and water extracts of coffee. The antioxidant capacity of the water extracts prepared according to the brewing procedure of Turkish coffee was measured for the first time by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and cupric ion reducing antioxidant capacity (CUPRAC) assays. The in vitro anticholinesterase activity of the coffee extracts and caffeine was determined for the first time. Water extracts of the coffee samples exhibited the highest 2,2--azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) cation radical scavenging, DPPH free radical scavenging and CUPRAC effects. The hexane extract of coffee roasted for 25 min showed the highest acetylcholinesterase inhibitory activity among the tested extracts. Caffeine, which is known to have therapeutic effect against Alzheimer-s disease, was found to possess almost the same anticholinesterase activity as galanthamine. The roasting degree had an irregular effect on the antioxidant and anticholinesterase activities of the coffee extracts. The caffeine contents in extracts of coffee roasted for 25 min, which had strong anticholinesterase effect, were determined by HPLC, and the water extract was found to possess the highest caffeine content.
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    Synthesis, antioxidant activity and SAR study of novel spiro-isatin-based Schiff bases
    (2018-12-01) Sönmez, Fatih; ZENGİN KURT, BELMA; Küçükislamoğlu, Mustafa; Avcı, Davut; GAZİOĞLU, IŞIL; Güneşli, Zuhal; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL
    A new series of 21 Schiff bases of spiro-isatin was synthesized, and their DPPH, CUPRAC and ABTS cation radical scavenging abilities were investigated for antioxidant activity. The results showed that all the synthesized compounds exhibited antioxidant activity for each assay. 5 & x30d;-(2,3-Dihydroxybenzylideneamino)spiro[[1,3] dioxolane-2,3 & x30d;-indoline]-2 & x30d;-on (5c) (IC50 = 4.49 mu M, for DPPH; IC50 = 0.39 mu M, for ABTS(.+); and A(0.50) = 0.42 mu M, for CUPRAC) showed significantly better ABTS, CUPRAC and DPPH radical scavenging ability than quercetin (IC50 = 8.69 mu M, for DPPH; IC50 = 15.49 mu M, for ABTS(.+); and A(0.50) = 18.47 mu M, for CUPRAC), which is used as a standard. SAR study showed that the synthesized compounds had higher ABTS(.+) activity than DPPH and CUPRAC activities. Moreover, the compounds (5c and 5d), containing two hydroxyl groups, exhibited the highest antioxidant activities for all assays. Quantum chemical calculations were also carried out to support SAR results.
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    Biological activities and phenolic-flavonoid contents of bilberry extracts
    (2012-12-01T00:00:00Z) Hacibekiroǧlu, IŞIL; KOLAK, Ufuk; GAZİOĞLU, IŞIL
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    Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives
    (2017-02-15) KURT, Belma Zengin; Gazioglu, IŞIL; Dag, AYDAN; Salmas, Ramin Ekhteiari; Kayik, Gulru; Durdagi, Serdar; Sonmez, Fatih; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; DAĞ, AYDAN
    New thymol and carvacrol derivatives with the carbamate moiety were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 5-isopropyl-2-methylphenyl(3-fluorophenyl)carbamate (29) was found to be the most potent AChE inhibitor with IC50 values of 2.22 mu M, and 5-isopropyl-2-methylphenyl (4-fluorophenyl)carbamate (30) exhibited the strongest inhibition against BuChE with IC50 value of 0.02 mu M. Additionally, the result of H4IIE hepatoma cell toxicity assay for compounds 18, 20, 29, 30 and 35 showed negligible cell death at 0.07-10 mu M. Moreover in order to better understand the inhibitory profiles of these molecules, molecular modeling studies were applied. Binding poses of studied compounds at the binding pockets of AChE and BuChE targets were determined. Predicted binding energies of these compounds as well as structural and dynamical profiles of molecules at the target sites were estimated using induced fit docking (IFD) algorithms and post-processing molecular dynamics (MD) simulations methods (i.e., Molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) approaches). (C) 2016 Elsevier Ltd. All rights reserved.
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    Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.
    (2017-01-01) Kalaycıoğlu, Zeynep; Gazioglu, IŞIL; Erim, F. Bedia; GAZİOĞLU, IŞIL
    Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer-s disease were controlled. Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity. The activity of demethoxycurcumin (DMC) followed BDMC, whereas curcumin showed very little acetylcholinesterase inhibition activity. Antidiabetic activity of curcuminoids was evaluated by their -glucosidase inhibitory activities. All curcuminoids show activities with decreasing order as BDMC>curcumin>DMC. The significant activities of BDMC compared to its isomers and examination of chemical structures of isomers might be a starting point in designing new drugs for Alzheimer-s and Diabetes Mellitus.
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    High performance liquid chromatographic analysis of lercanidipine in human breast milk
    (2019-01-01) Tekkeli, Evrim Kepekci; GAZİOĞLU, IŞIL; TIRIS, GİZEM; Onal, Cem; TEKKELİ, ŞERİFE EVRİM; GAZİOĞLU, IŞIL; TIRIS, GİZEM
    A simple, rapid, precise and accurate isocratic reversed phase HPLC method was developed and validated for the determination of lercanidipine hydrochloride in pharmaceutical tablets and spiked human breast milk. The chromatographic separation was achieved on C18 (250x4.6 mmx5 mu m) column using a mobile phase consisting of acetonitrile and phospate buffer (pH=4) (55:45, v/v) at a flow rate of 1.1 mL/min and UV detection at 237 nm. The linearity of the proposed method was investigated in the range of 1.0-40 mu g/mL (r(2)=0.9990). The method was validated in terms of accuracy, precision, reproducibility, specificity, robustness, and detection and quantification limits, in accordance with ICH guidelines. The proposed method is found as suitable for routine quantification of lercanidipine in human breast milk.
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    Antioxidant and anticholinesterase activities of eleven edible plants
    (2011-03-01T00:00:00Z) Boga, Mehmet; Hacibekiroglu, IŞIL; Kolak, Ufuk; GAZİOĞLU, IŞIL
    Objective: The antioxidant potential and anticholinesterase activity of eleven edible plants were investigated.
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    Fatty Acid, Essential Oil and Phenolic Compositions of Alcea pallida and Alcea apterocarpa with Antioxidant, Anticholinesterase and Antimicrobial Activities
    (2016-01-01) Ertas, Abdulselam; Boga, Mehmet; Gazioglu, IŞIL; Yesil, Yeter; Hasimi, Nesrin; Ozaslan, Cumali; YILMAZ, Hasibe; KAPLAN, Muammer; GAZİOĞLU, IŞIL
    This study was the first phytochemical and biological activity report on Alcea pallida and Alcea apterocarpa extracts. The main constituents of the essential oils were identified as arachidic acid (34.2%) for A. pallida, and hexatriacontane (25.3%) for A. apterocarpa. The main constituents of the fatty acids obtained from petroleum ether extracts of A. pallida and A. apterocarpa were identified as palmitic acid (31.2%) and oleic acid (25.6%), respectively. The phenolic compositions of the samples were determined using HPLC (LC-20 liquid chromatographic system). A. pallida and A. apterocarpa showed the same peaks which were ascorbic, caffeic, salicylic and p-hydroxybenzoic acids and quercetin, respectively. Salicylic acid showed the highest abundance. Among the eight extracts, the acetone extract of A. pallida possessed the best ABTS cation radical scavenging activity and moderate butyryl-cholinesterase activity at 200 mu g/mL. The A. pallida acetone extract exhibited 53.12% inhibition in DPPH free radical scavenging activity method at 100 mu g/mL concentration. The acetone extract of A. pallida showed weak antimicrobial activity against Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa and moderate activity against Candida albicans (inhibition zone diameter 16 mm). The acetone extract of A. apterocarpa showed moderate activity against C. albicans (inhibition zone diameter 14 mm) and S. aureus (inhibition zone diameter 13 mm); weak activity against E. coli., S0 pyogenes, and P. aeruginosa.
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    In vitro biological activities and fatty acid profiles of Pistacia terebinthus fruits and Pistacia khinjuk seeds
    (2015-03-04) Hacibekiroglu, IŞIL; Yilmaz, Pelin Koseoglu; Hasimi, Nesrin; Kilinc, Ersin; Tolan, Veysel; Kolak, Ufuk; GAZİOĞLU, IŞIL
    This study reports in vitro anticholinesterase, antioxidant and antimicrobial effects of the n-hexane, dichloromethane, ethanol and ethanol-water extracts prepared from Pistacia terebinthus L. fruits and Pistacia khinjuk Stocks seeds as well as their total phenolic and flavonoid contents, and fatty acid compositions. Ethanol and ethanol-water extracts of both species exhibited higher anticholinesterase activity than galanthamine. Among ABTS, DPPH and CUPRAC assays, the highest antioxidant capacity of the extracts was found in the last one. P. terebinthus ethanol extract being rich in flavonoid content showed the best cupric reducing effect. All extracts possessed no antimicrobial activity. The main fatty acid in P. terebinthus fruits (52.52%) and P. khinjuk seeds (59.44%) was found to be oleic acid. Our results indicate that P. terebinthus fruits and P. khinjuk seeds could be a good source of anticholinesterase compounds, and could be phytochemically investigated.
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    Synthesis, Anticholinesterase, Antioxidant, and Anti-Aflatoxigenic Activity of Novel Coumarin Carbamate Derivatives
    (2018-04-17) KURT, Belma Zengin; Gazioglu, IŞIL; KANDAS, Nur Ozten; Sonmez, Fatih; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL
    New coumarin derivatives with the carbamate moiety were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 4-methyl-2-oxo-2H-chromen-7-yl cycloheptylcarbamate (4h) showed the strongest inhibition against AChE with IC50 values of 2.30 mu M, and 2-oxo-2H-chromen-7-yl-(cyclohexylmethyl)carbamate (4c) and 4-methyl-2-oxo-2H-chromen-7-yl-(cyclohexylmethyl)carbamate (4g) were found to be the most potent BuChE inhibitors with IC50 value of 0.003 mu M and 0.004 mu M, respectively. Moreover antioxidant, anti-aflatoxigenic activities, protective effects against aflatoxin-B1 (AFB1) in H4IIE-C3 cells and effects on glutathione s-transferase of the synthesized compounds were investigated. The synthesized coumarin carbamates inhibited AFB1 in H4IIE-C3 cells. Western blot analyses confirmed that GST alpha protein was induced in cells treated with coumarin carbamates and AFB1. These results showed that the synthesized coumarin carbamates possess a potent protective effect against AFB1.