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DOĞAN, BAYRAM

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BAYRAM
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DOĞAN
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    PublicationOpen Access
    The relationship of neutrophil to lymphocyte ratio with testicular cancer
    (2020-01-01) İlktaç, Abdullah; Akbulut, Habib; Akçay, Muzaffer; Ersöz, Cevper; Doğan, Bayram; İLKTAÇ, ABDULLAH; DOĞAN, BAYRAM; ERSÖZ, CEVPER; AKÇAY, MUZAFFER; AKBULUT, HABİB
    Purpose: To assess the relationship between testicular germ cell tumors (TGCT) and neutrophil to lymphocyte ratio (NLR) and to determine whether this ratio can be used as a serum tumor marker. Material and Methods: Sixty-one patients with testicular germ cell tumors were included into the study. Patients were grouped as localized and non-localized. Histologically patients were categorized as seminoma and nonseminomatous germ cell tumors. Complete blood cell count was measured the day before surgery and at the postoperative 1st month. Preoperative and postoperative mean NLR values were compared. Results: Thirty-six patients (59%) had seminomas and 25 patients (41%) had nonseminomatous testicular cancer. Forty-fi ve patients (73.8%) had localized and 16 patients (26.2%) had non-localized testicular cancer. There was a statistically signifi cant difference between preoperative and postoperative mean NLR of the localized patients (p=0.001) but no such difference was detected for non-localized patients (p=0.576). Nineteen patients with localized seminomas had normal preoperative serum tumor markers. There was a signifi cant difference between preoperative and postoperative mean NLR in this group of patients (p=0.010). Twenty-six patients with localized tumors had preoperative increased serum tumor markers which normalized after orchiectomy. Mean NLR of these patients signifi cantly decreased from 3.10±2.13 to 1.62±0.59 postoperatively (p=0.010). Conclusions: NLR appears to be a useful marker for TGCT. It is successful in predicting localized and non-localized disease in early postoperative period.
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    PublicationOpen Access
    Mesh related vesico-peritoneal fistula presenting with urinary ascites: A case report
    (2019-03-01T00:00:00Z) İLKTAÇ, ABDULLAH; ERSÖZ, CEVPER; DOĞAN, BAYRAM; KALKAN, Senad; İLKTAÇ, ABDULLAH; ERSÖZ, CEVPER; DOĞAN, BAYRAM; KALKAN, SENAD
    Vesicoperitoneal fistula is a very rare entity of epithelialized communication between peritoneal cavity and bladder.1 It results in accumulation of urine in peritoneal cavity and causes elevated urea and creatinine levels mimicking acute renal failure. Incisional hernia is common complication of abdominal surgery and often repaired with non-absorbable mesh.2 Using dual mesh can reduce mesh related complications but migration to adjacent organs can still happen and cause severe complications. Here we present a case of mesh related vesico-peritoneal fistula presenting with urinary ascites 2 years after incisional hernia repair.
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    PublicationOpen Access
    Expression of transient receptor potential melastatin 4 in differential diagnosis of eosinophilic renal tumors
    (2021-11-01T00:00:00Z) ÇOBAN, GANİME; YILDIZ, PELİN; DOĞAN, BAYRAM; ŞAHİN, NURHAN; GÜCİN, ZÜHAL; ÇOBAN, GANİME; YILDIZ, PELİN; DOĞAN, BAYRAM; ŞAHİN, NURHAN; GÜCİN, ZÜHAL
    Immunohistochemical and molecular studies to differentiate eosinophilic kidney tumors are gradually increasing. The present study investigated the role of transient receptor potential cation channel subfamily M member 4 (TRPM4), a non-selective cation channel associated with migration, proliferation and invasion in cancer cells, in this differentiation. The aim was to investigate the effectiveness of TRPM4 in differentiation of eosinophilic kidney tumors. The study included a total of 112 patients, including 97 eosinophilic kidney tumors with the diagnoses of 33 eosinophilic clear cell renal cell carcinoma (CCRCC), 35 eosinophilic chromophobe renal cell carcinoma (ChRCC), 8 papillary renal cell carcinoma type 2 (P2RCC), 21 renal oncocytoma (RO), as well as 15 papillary renal cell carcinoma type 1 to differentiate from P2RCC. For TRPM4, diffuse staining (>10%) was observed in 2 CCRCC, 15 ChRCC, 20 RO and 4 P2RCC cases. There was a significant difference between eosinophilic CCRCC and other eosinophilic tumors (P<0.05). While basolateral staining was observed in papillary tumors, membrane staining was observed in other stained cases. It was hypothesized that the use of TRPM4 along with morphological findings, cytokeratin 7 and other markers may be useful for the differentiation of eosinophilic kidney tumors.