Person: YEŞİLBAŞ, OSMAN
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Publication A Case of Bronchiolitis Obliterans Secondary to Human Metapneumovirus Bronchiolitis(2016-10-01T00:00:00Z) yeşilbaş, OSMAN; şevketoğlu, Esra; kıhtır, Hasan Serdar; TALIP PETMEZCI, Mey; bato, Elif; balkaya, Seda; hatipoğlu, Nevin; Kuskucu, Mert Ahmet; PALABIYIK, Figen; Cakir, ERKAN; YEŞİLBAŞ, OSMAN; ÇAKIR, ERKANHuman metapneumovirus (hMPV), formerly classified in Paramyxoviridae family is now moved into Pneumoviridae, which was described as a novel family. It causes upper and lower respiratory tract infections (LRTIs) usually in children younger than five years old. The recent epidemiological studies indicated that hMPV is the second most frequently detected virus in LRTIs of young children, following the respiratory syncytial virus (RSV). Bronchiolitis obliterans (BO) is a chronic obstructive lung disease characterized by fibrosis of the distal respiratory airways. It is usually a result of an inflammatory process triggered by a LRTI related to adenovirus, RSV, Mycoplasma pneumoniae, measles virus, Legionella pneumophila, influenza virus or Bordetella pertussis as a causative agent. In this report, a case of hMPV bronchiolitis complicated with BO has been reported to point out the complications and severity of the clinical progress belongs to this virus. A three-month-old female patient has admitted to our pediatric intensive care unit with the diagnosis of acute bronchiolitis and respiratory failure. She was born at term, weighing 2950 gram and had been hospitalized in newborn intensive care unit for 11 days with the diagnosis of transient tachypnea of the newborn and neonatal sepsis. On auscultation, there were bilateral crepitant rales, wheezing and prolonged expirium. Her oxygen saturation was 97-98% while respiratory support was given with a non-rebreathing reservoir mask. Complete blood count, procalcitonin and C-reactive protein levels were in normal ranges. The chest radiography yielded right middle lobe atalectasia, left paracardiac infiltration and bilateral air trapping. A nasopharyngeal swab sample was analyzed by a commercial multiplex real-time reverse transcriptase-polymerase chain reaction (Thermo Fisher Scientific (R), USA) developed for the detection of 15 respiratory viruses. Her sample yielded positive result for only hMPV. On the 4th day of hospitalization, the patient was intubated because of respiratory failure and carbon dioxide retention. She was extubated on the 19th day but could not tolerate. In the thorax computed tomography (CT), bilateral hyperinflation, patchy infiltration, mosaic perfusion and atelectasis especially bilateral posterior areas were detected. Bronchoscopy was normal except mild bronchomalacia in right middle lobe bronchus. The patient was diagnosed as BO secondary to hMPV bronchiolitis, according to the clinical, virological, bronchoscopic and thorax CT results. On the 76th day of admission, she was discharged with respiratory support with home ventilation via a tracheostomy cannula and medical treatments of oral metilprednisolone, nebulized salbutamol and budesonide. In conclusion, hMPV should not be undervalued especially in infants with severe LRTI that can be complicated with BO.Publication Persistent pleural effusion in an infant with an unusual diagnosis: congenital alveolar rhabdomyosarcoma(2020-01-01T00:00:00Z) Yozgat, Can Yilmaz; YEŞİLBAŞ, Osman; YOZGAT, Yılmaz; AKDEMİR, OSMAN CEMİL; YURTSEVER, İsmail; TEKİN, NUR; BAGHISHOV, DAMAT; BAYRAMOVA, NİGAR; ELAGÖZ, Şahande; ÇAKIR, FATMA BETÜL; YEŞİLBAŞ, OSMAN; YOZGAT, YILMAZ; AKDEMİR, OSMAN CEMİL; YURTSEVER, İSMAİL; TEKİN, NUR; BAGHISHOV, DAMAT; BAYRAMOVA, NİGAR; ELAGÖZ, ŞAHANDE; ÇAKIR, FATMA BETÜLRhabdomyosarcoma (RMS) is a malignant form of neoplasm that originates from skeletal muscle. RMSs can exist anywhere in the human body but are more commonly detected in the neck region and extremities. The alveolar type is one of the subtypes of RMS that has a poor prognosis. Because the clinical manifestation of a tumour can be a painless mass, symptoms might be non-contributary to the diagnosis. Herein, a four-month-old girl was admitted to the emergency department with complaints of respiratory distress without a runny nose, cough, and fever. Recurrent effusions subsided with subsequent tube thoracostomy. Video-assisted thoracoscopic surgery (VATS) was performed to determine the aetiology of the recurrent effusion. The Tru-Cut biopsy obtained during VATS resulted in the diagnosis of alveolar rhabdomyosarcoma. Pleural effusion decreased, and the tube drainage was stopped rapidly after first vincristine, actinomycin-D, and cyclophosphamide chemotherapy cycle. Persistent and recurrent pleural effusions should alert physicians to rule out unusual diagnoses like that of our case.Publication Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli(2021-09-01T00:00:00Z) YEŞİLBAŞ, Osman; Yozgat, Can Yilmaz; AKINCI, NURVER; SÖNMEZ, ŞİRİN; TEKİN, ESER; TALEBAZADEH, FARAZ; JAFAROV, UZEYİR; OTÇU TEMUR, Hafize; YOZGAT, YILMAZ; YEŞİLBAŞ, OSMAN; AKINCI, NURVER; SÖNMEZ, ŞİRİN; TEKİN, ESER; TALEBAZADEH, FARAZ; JAFAROV, UZEYİR; OTÇU TEMUR, HAFİZE; YOZGAT, YILMAZCardiovascular involvement is uncommon in pediatric patients with hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC-HUS). In this case report we presented a case of 17-month-old toddler who had a sporadic type of STEC-HUS complicated by acute myocarditis. The patient was successfully treated by a single dose of eculizumab after six doses of therapeutic plasma exchange (TPE) were inefficient to prevent the cardiac complication. Hepatotoxicity was observed after a single dose of eculizumab. Hepatic and cholestatic enzyme levels slowly returned to normal within 6 months. To the best of our knowledge, this is the first case of myocarditis/cardiomyopathy treated with eculizumab in STEC-HUS. This case illustrates the need for vigilance regarding myocardial involvement and eculizumab-induced hepatotoxicity in STEC-HUS.Publication Subdural empyema, brain abscess, and superior sagittal sinus venous thrombosis secondary to Streptococcus anginosus(2021-01-01T00:00:00Z) YEŞİLBAŞ, Osman; YOZGAT, Can Yılmaz; Tahaoglu, Irmak; BURSAL DURAMAZ, BURCU; TÜREL, Özden; TEKİN, NUR; UZUNER, SELÇUK; Abdallah, Anas; YEŞİLBAŞ, OSMAN; YOZGAT, YILMAZ; BURSAL DURAMAZ, BURCU; TÜREL, ÖZDEN; TEKİN, NUR; UZUNER, SELÇUKStreptococcus anginosus can be frequently isolated from brain abscesses, but is a rare cause of the liver, lung, and deep tissue abscesses. In this report, we present a patient with subdural empyema, brain abscess, and superior sagittal cerebral venous thrombosis as complications of rhinosinusitis whose purulent empyema sample yielded S. anginosus. A 13-year-old female patient was referred to our pediatric intensive care unit with altered mental status, aphasia, and behavioral change. On a brain computed tomography scan, subdural empyema extending from the left frontal sinus to the frontal interhemispheric area and left hemispheric dura was detected. Intravenous ceftriaxone, vancomycin, and metronidazole treatments were started. Subdural empyema was surgically drained. Postoperative brain magnetic resonance venography imaging showed superior sagittal sinus thrombosis. Cultures obtained from purulent empyema sample revealed S. anginosus. On the third day of hospitalization, a brain computed tomography scan showed brain edema, especially in the left hemisphere and significantly increased subdural empyema that had been previously drained. She was reoperated and decompressive craniectomy was performed. On the fifth day, partial epileptic seizures occurred. Brain magnetic resonance imaging showed a brain abscess on the interhemispheric area. The magnetic resonance imaging findings of abscess formation improved on 30th day and she was discharged on the 45th day after the completion of antibiotic therapy.Publication Multiple Brain Abscesses Due to Actinomyces Odontolyticus: A Rare Infection In a Previously Healthy Child(2019-11-01T00:00:00Z) Oztanir, Mustafa Namik; SARITAŞ, BETÜL; Duramaz, Burca Bursal; YEŞİLBAŞ, Osman; Nizam, Oznur Gokce; TEKİN, Abdurrahim; TÜREL, Özden; BARIŞ, SAFA; SARITAŞ, BETÜL; YEŞİLBAŞ, OSMAN; ÖZTANIR, MUSTAFA NAMIK; TEKİN, ABDURRAHIM; TÜREL, ÖZDENPublication Late Diagnosis of MELAS Can Lead to A Serious Brain Edema that Ultimately Requires Decompressive Craniectomy(2019-11-01T00:00:00Z) Nizam, Oznur Gokce; ŞENGENÇ, ESMA; YEŞİLBAŞ, OSMAN; Sahin, Seyma Sonmez; İŞCAN, AKIN; İÇAĞASIOĞLU, DİLARA FÜSUN; ŞENGENÇ, ESMA; YEŞİLBAŞ, OSMAN; İŞCAN, AKIN; İÇAĞASIOĞLU, DİLARA FÜSUNPublication Williams Syndrome Presenting with Intractable Staphylococcus aureus Endocarditis(2020-02-14T04:00:00Z) Yozgat, Can Yilmaz; UZUNER, SELÇUK; Yesilbas, Osman; BURSAL DURAMAZ, BURCU; YOZGAT, Yılmaz; İŞCAN, AKIN; TÜREL, Özden; UZUNER, SELÇUK; YEŞİLBAŞ, OSMAN; BURSAL DURAMAZ, BURCU; YOZGAT, YILMAZ; İŞCAN, AKIN; TÜREL, ÖZDENPublication Life-threatening multiple brain abscesses secondary to Actinomyces odontolyticus(2020-11-01T00:00:00Z) YEŞİLBAŞ, Osman; Yozgat, Can Yilmaz; Nizam, Oznur Gokce; BURSAL DURAMAZ, BURCU; TÜREL, Özden; YEŞİLBAŞ, OSMAN; BURSAL DURAMAZ, BURCU; TÜREL, ÖZDENPublication Recurrent Elevation of Troponin Levels in Acute Myocarditis: Is it a Sign of Ventricular Tachycardia?(2020-07-01T00:00:00Z) Yozgat, Can Yilmaz; YEŞİLBAŞ, Osman; UZUNER, SELÇUK; SARITAŞ, BETÜL; ERGÖR, Serap Nur; OTÇU TEMUR, Hafize; YOZGAT, Yılmaz; YEŞİLBAŞ, OSMAN; UZUNER, SELÇUK; SARITAŞ, BETÜL; ERGÖR, SERAP NUR; OTÇU TEMUR, HAFİZE; YOZGAT, YILMAZPublication A Rare Presentation of Neurobrucellosis in a 6-Year-Old Pediatric Patient with Sagittal Sinus Thrombosis(2020-10-01T00:00:00Z) TÜREL, Özden; KUTLU, NURETTİN ONUR; YEŞİLBAŞ, Osman; Yozgat, Can Yilmaz; DÜNDAR, TOLGA TURAN; BURSAL DURAMAZ, BURCU; UZUNER, SELÇUK; ABDİLLAHİ, FATOUMA KHALİF; TÜREL, ÖZDEN; UZUNER, SELÇUK; BURSAL DURAMAZ, BURCU; DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; YEŞİLBAŞ, OSMAN; KUTLU, NURETTİN ONURBrucellosis is one of the most common zoonosis worldwide. It is still endemic in many regions of the world. A 6-year-old female was admitted to the emergency department (ED) due to a sudden change in consciousness, urinary incontinence, vomiting, and difficulty in walking. Neurological examination demonstrated abducens nerve paralysis, mild-to-moderate motor deficit in hemiparesis in the left arm. Brain magnetic resonance imaging showed a hemorrhagic focus at the right frontal lobe and thrombosis in the superior sagittal sinus of the brain. The diagnosis of neurobrucellosis was confirmed by identifying Brucella spp. in the blood culture on the day 6 of pediatric intensive care unit admission; thus, trimethoprim-sulfamethoxazole and rifampicin, and ceftriaxone were promptly initiated. Despite neuroprotective management and acetazolamide, the patient-s neurological problems and high intracranial pressure (ICP) persisted. An external ventricular drainage tube and a Codman ICP monitor were placed to be on the consent vigilance of the patient-s neurological condition. The patient-s ICP continued to increase despite the current treatment regimen; therefore, a decompressive bitemporal craniectomy was performed. The ICP level of the patient returned to its normal range immediately after the craniectomy. The patient did not have any notable neurologic sequelae at the first-year follow-up. Neurobrucellosis is a rare complication of systemic brucellosis and may present as meningitis, encephalitis, myelitis, radiculitis, and/or neuritis. Herein, we describe a six-year-old girl with brucellosis complicated with cerebral vein thrombosis. This case illustrates the need for close monitoring of patients with unexplained neurological signs or symptoms for brucellosis in endemic areas.