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BAYRAKTAR, HAVVANUR

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HAVVANUR

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BAYRAKTAR

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Start date: 2017End date: 2019Has files: falseAuthor: Bayraktar, HAVVANUR

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    A novel tool reflecting the role of oxidative stress in the cataracts: thiol/disulfide homeostasis
    (2017-01-01) Elbay, AHMET; Ozer, Omer Faruk; ALTINISIK, Muhammed; ELBAY, Arif Emre; Sezer, TAHA; Bayraktar, HAVVANUR; OZDEMIR, Hakan; ELBAY, AHMET; ÖZER, ÖMER FARUK; SEZER, TAHA; BAYRAKTAR, HAVVANUR; ÖZDEMİR, MEHMET HAKAN
    We investigated serum and aqueous humor thiol/disulfide (T-D) homeostasis in patients with cataracts versus healthy controls. In total, 56 patients with cataracts and 49 healthy controls were enrolled in this case-control study. Serum total thiol (TT), native thiol (NT), and disulfide (DS) concentrations were determined using a novel automated measurement method. Additionally, DS/TT, DS/NT and NT/TT percentage ratios were compared between the groups. In comparison with the control group, serum NT levels and aqueous humor TT and NT levels were significantly lower (p<.05, p<.05 and p<.001, respectively), whereas serum and aqueous humor DS levels were significantly higher in cataract patients (p<.01 and p<.001). DS/TT and DS/NT ratios were significantly higher and the NT/TT ratio was lower in cataract patients in serum (p<.005) and aqueous humor samples (p<.001). In conclusion, serum T-D homeostasis may be useful as biochemical markers, indicating the role of oxidative stress in the development of cataracts. Further studies are needed to confirm the pathophysiological role of T-D homeostasis in cataractogenesis.