Purpose. To describe a novel method for the treatment of refractory macular holes. Methods. Two case reports on the use of autologous
platelet rich fibrin (PRF), followed by sulfur hexafluoride gas tamponade to facilitate closure of refractory macular holes. Results.
Macular holes were succesfully closed within a week in both cases. Best corrected Snellen visual acuities improved from counting
fingers to 0.16 in the first case, and from 0.05 to 0.2 in the second case. No complication occurred during or a er the procedures.
Conclusion. e use of autologous PRF seems to be a safe and effective alternative method for the treatment of refractory macular
holes. Further experience and studies are required to assess the value of autologous PRF in the management of challenging macular
hole cases of different etiologies. To the best of our knowledge, this is the first use of autologous PRF in the treatment of macular holes.
