Person: ERSÖZ, CEVPER
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Publication Open Access The relationship of neutrophil to lymphocyte ratio with testicular cancer(2020-01-01) İlktaç, Abdullah; Akbulut, Habib; Akçay, Muzaffer; Ersöz, Cevper; Doğan, Bayram; İLKTAÇ, ABDULLAH; DOĞAN, BAYRAM; ERSÖZ, CEVPER; AKÇAY, MUZAFFER; AKBULUT, HABİBPurpose: To assess the relationship between testicular germ cell tumors (TGCT) and neutrophil to lymphocyte ratio (NLR) and to determine whether this ratio can be used as a serum tumor marker. Material and Methods: Sixty-one patients with testicular germ cell tumors were included into the study. Patients were grouped as localized and non-localized. Histologically patients were categorized as seminoma and nonseminomatous germ cell tumors. Complete blood cell count was measured the day before surgery and at the postoperative 1st month. Preoperative and postoperative mean NLR values were compared. Results: Thirty-six patients (59%) had seminomas and 25 patients (41%) had nonseminomatous testicular cancer. Forty-fi ve patients (73.8%) had localized and 16 patients (26.2%) had non-localized testicular cancer. There was a statistically signifi cant difference between preoperative and postoperative mean NLR of the localized patients (p=0.001) but no such difference was detected for non-localized patients (p=0.576). Nineteen patients with localized seminomas had normal preoperative serum tumor markers. There was a signifi cant difference between preoperative and postoperative mean NLR in this group of patients (p=0.010). Twenty-six patients with localized tumors had preoperative increased serum tumor markers which normalized after orchiectomy. Mean NLR of these patients signifi cantly decreased from 3.10±2.13 to 1.62±0.59 postoperatively (p=0.010). Conclusions: NLR appears to be a useful marker for TGCT. It is successful in predicting localized and non-localized disease in early postoperative period.Publication Open Access Mesh related vesico-peritoneal fistula presenting with urinary ascites: A case report(2019-03-01T00:00:00Z) İLKTAÇ, ABDULLAH; ERSÖZ, CEVPER; DOĞAN, BAYRAM; KALKAN, Senad; İLKTAÇ, ABDULLAH; ERSÖZ, CEVPER; DOĞAN, BAYRAM; KALKAN, SENADVesicoperitoneal fistula is a very rare entity of epithelialized communication between peritoneal cavity and bladder.1 It results in accumulation of urine in peritoneal cavity and causes elevated urea and creatinine levels mimicking acute renal failure. Incisional hernia is common complication of abdominal surgery and often repaired with non-absorbable mesh.2 Using dual mesh can reduce mesh related complications but migration to adjacent organs can still happen and cause severe complications. Here we present a case of mesh related vesico-peritoneal fistula presenting with urinary ascites 2 years after incisional hernia repair.Publication Open Access Comparison of Scoring Systems in Predicting Success of Percutaneous Nephrolithotomy(2019-01-01T00:00:00Z) AKÇAY, MUZAFFER; Tosun, Muhammed; GEVHER, FATİH; KALKAN, Senad; ERSÖZ, CEVPER; Kayali, Yunus; Tepeler, Abdulkadir; AKÇAY, MUZAFFER; TOSUN, MUHAMMED; GEVHER, FATİH; KALKAN, SENAD; ERSÖZ, CEVPER; KAYALI, YUNUSBackground: Scoring systems are useful to inform the patients about the success and complication rates of the operation prior the surgery. Aims: To determine the applicability of the popular scoring systems (Guy’s, stone size, tract length, obstruction, number of involved calices, and essence/stone density and Clinical Research Office of the Endourological Society) by means of examining preoperative data of patients treated with percutaneous nephrolithotomy. Study Design: Cross sectional study. Methods: We retrospectively reviewed files of the patients who had undergone percutaneous nephrolithotomy in our center between 2011 and 2015. Excluded from the study were patients aged <18 years, and those who were not assessed preoperatively with computed tomography. Preoperative computed tomography images of all patients were assessed by a single observer, and patients were graded based on three scoring system. Demographic data were analyzed along with perioperative data (operation, fluoroscopy, length of hospital stay, changes in hematocrit values, location, and number of access sites, stone-free and complication rates). Results: A total of 298 patients who had been treated with 300 procedures were enrolled into the study. Mean age, stone burden, number of stones, and density were 48.1±12.9 years, 663.5±442.8 mm2, 1.8±1.1 and 888.3±273 HU respectively. Scores of the cases based on Guy’s, stone size, tract length, obstruction, number of involved calices, and essence/stone density, and Clinical Research Office of the Endourological Society scoring system were calculated as 2, 7.6, and 222.1 points respectively. 81.6% of the patients were stonefree. Complications were detected in 30 (9.9%) patients. Based on receiver operating characteristic curve analysis a positive correlation was detected between success rate and scoring systems, i.e., Guy’s (p=<0.001, r=-0.309), stone size, tract length, obstruction, number of involved calices, and essence/stone density (p=<0.001, r=-0.295), and Clinical Research Office of the Endourological Society (p=<0.001, r=0.426). The Clinical Research Office of the Endourological Society scoring system had the highest predictive value. The sensitivity rates rates for Guy’s, Clinical Research Office of the Endourological Society and Stone scoring system were as 78.78%, 80% and 82.34% respectively. Conclusion: All of scoring systems predicted correctly the success of the percutaneous nephrolithotomy procedures. The Clinical Research Office of the Endourological Society scoring system had the highest predictive value. Keywords: Percutaneous nephrolitotomy, scoring methods, specificity and sensitivity, urinary calculiPublication Open Access Impact of Percutaneous Renal Access Technique on Outcomes of Percutaneous Nephrolithotomy(2012-07-01T00:00:00Z) TEPELER, Abdulkadir; ARMAGAN, Abdullah; AKMAN, Tolga; POLAT, Emre Can; Ersoz, CEVPER; TOPAKTAS, Ramazan; ERDEM, Mehmet Remzi; ONOL, Sinasi Yavuz; ERSÖZ, CEVPERBackground and Purpose: Percutaneous nephrolithotomy (PCNL) is regarded as the gold standard for the treatment of patients with renal stones larger than 2 cm in diameter. Creating a percutaneous renal access is the initial and probably the most important step in performing a PCNL. Two primary methods of obtaining proper percutaneous renal access under fluoroscopic guidance are described: The -triangulation- and the -eye of the needle- techniques. In this article, we compare these two techniques in terms of success and complication rates.Publication Open Access The role of oxidative stress and inflammation biomarkers in pre- and postoperative monitoring of prostate cancer patients(2024-02-23) Beyaztas H.; ERSÖZ C.; Ozkan B. N.; OLĞUN İ.; Polat H. S.; Dastan A. I.; Cetinkaya E.; Guler E. M.; ERSÖZ, CEVPER; OLĞUN, İBRAHİM; GÜLER, ERAY METİNIntroduction: Prostate Cancer (PC) is a global health concern affecting men worldwide. Oxidative stress is believed to contribute to the initiation of early-stage PC lesions. Additionally, inflammation has long been acknowledged as a factor in the development of PC. We aimed to examine the biomarkers of oxidative stress and inflammation in PC patients before and after surgery. Patients and methods: A cross-sectional study was conducted at the Urology Outpatient Clinic of Bezmialem Vakif University Hospital. A total of 150 individuals were included in the study, divided into five groups: 50 Healthy controls, 25 patients with Benign Prostatic Hyperplasia (BPH), 25 patients with Low-Risk Prostate Cancer (LRPC), 25 patients with Medium-Risk Prostate Cancer (MRPC), and 25 patients with High-Risk Prostate Cancer (HRPC). Measurements of Total Oxidant Status (TOS), Total Antioxidant Status (TAS), Total Thiol (TT), and Native Thiol (NT) were performed using photometric methods. Oxidative Stress Index (OSI) and Disulfide (DIS) levels were calculated mathematically. Levels of Interleukin-10 (IL-10), Interleukin-1beta (IL-1β), Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), and Presepsin were determined using commercially available enzyme-linked immunosorbent assay (ELISA) kits. Results: Compared to the healthy control group, the results indicated a statistically significant increase in both oxidative stress and inflammation levels. In the groups receiving both pharmaceutical therapy and surgical treatment (PC), a significant decrease in oxidative stress and inflammation levels was observed. Conclusion: Consequently, it is suggested that the assessment of oxidative stress and inflammatory biomarkers should be incorporated in the pre- and postoperative monitoring of patients with PC.