Person: ERSOY, YELIZ EMINE
Search Results
p53 expression and relationship with MDM2 amplification in breast carcinomas
2016-04-01, Buyukpinarbasili, NUR, Gucin, ZÜHAL, Ersoy, YELİZ EMİNE, ILBAK, Ayca, Kadioglu, HÜSEYİN, Muslumanoglu, Mahmut, BÜYÜKPINARBAŞILI, NUR, GÜCİN, ZÜHAL, ERSOY, YELIZ EMINE, KADIOĞLU, HÜSEYİN
Carcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation domain of p53. The loss of MDM2 function on p53 regulation results in deprivation of p53 tumor suppressor ability. Single nucleotide polymorphisms (SNP309 T->G exchange) or MDM2 amplification has been proposed to play a role in this issue. In the present study, our aim is to analyze p53 and MDM2 status and investigate their interactions in human sporadic breast carcinoma. The study groups were separated according to their molecular classifications. In each group, histologic type of the tumor, conventional prognostic parameters, p53, and MDM2 interactions were compared statistically. Tumors are divided into 4 subtypes due to estrogen and progesterone receptor status, HER-2, and Ki-67 proliferation index results. According to this classification, 23 cases are in the luminal A, 32 cases are in the luminal B, 15 cases are in the HER-2 positive, and 22 cases are in the triple-negative group, with a total of 92 cases. p53 expression is low in luminal breast carcinomas than HER-2 and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total. MDM2 gene amplification does not have a significant role in breast carcinogenesis, but other possible mechanisms may play a role in its inactivation. (C) 2016 Elsevier Inc. All rights reserved.
Does adrenaline spraying over thyroidectomy area reduce bleeding?
2014-01-01, AYSAN, Erhan, MERIC, Aysenur, Kadioglu, HÜSEYİN, CENGIZ, Merve B., Bozkurt, SÜLEYMAN, Memmi, NAİM, CIPE, Gokhan, MUSLUMANOGLU, Mahmut, ERSOY, YELIZ EMINE, AYŞAN, MUSTAFA ERHAN, MERİÇ HAFIZ, AYŞENUR, KADIOĞLU, HÜSEYİN, BOZKURT, SÜLEYMAN, MEMMİ, NAİM
Background: Means to prevent and control intra-or postoperative bleeding remain a topic of utmost importance in thyroidectomy. In this randomised clinical trial, we used adrenaline spraying to see if it helps bleeding control and reduces drainage and hematoma formation after thyroidectomy. Methods: After total thyroidectomy, 1 mg/ml adrenaline solution in 10 ml saline was sprayed all over the operation area by a syringe in 40 patients of -Adrenaline (+) Group-. In the other 40 patients in -Adrenaline (-) Group-, only standart total thyroidectomy was performed. Drainage amounts of 24 hours were recorded. Results: Among 80 patients, 66 (82.5%) were female and 14 (17.5%) were male. The daily drainage amounts of the Adrenaline (+) Group were found statistically significantly lower than the Adrenaline (-) Group (p<0.05). In both of the groups, thyroid volumes were significantly correlated with the drainage amounts. -p- values were 0.008 and <0.001 in Adrenaline (+) and Adrenaline (-) Groups, respectively. Conclusions: Preliminary experience using adrenaline has been encouraging and it is useful as an adjunct to thyroid surgery in order to prevent hemorrhagia and give up drain placement. But prospective randomized trials using adequate patient numbers are still needed to validate efficacy and safety.
Feasibility of breast conserving surgery in multifocal breast cancers
2014-09-01, Kadioglu, HÜSEYİN, YUCEL, Serap, Yildiz, Seyma, Bozkurt, SÜLEYMAN, Ersoy, YELİZ EMİNE, SAGLAM, Esra, MUSLUMANOGLU, Mahmut, KADIOĞLU, HÜSEYİN, YILDIZ, ŞEYMA, BOZKURT, SÜLEYMAN, ERSOY, YELIZ EMINE
BACKGROUND: Multifocal breast cancers (MFBCs) present a challenge to surgeons. Although its feasibility is still controversial, breast-conserving surgery (BCS) is not contraindicated for MFBCs. The investigators retrospectively evaluated the feasibility of BCS and reviewed histopathologic findings in patients with MFBC.
Neoadjuvan tedavi sonrası subkutan mastektomi uygulanan multifokal meme kanserinde implant ve Allogreft ile onkoplastik tedavi yaklaşımı: Erken sonuçlarımız
2014-04-20, MALYA, FATMA ÜMİT, HASBAHCECI, MUSTAFA, ERSOY, YELİZ EMİNE, KADIOĞLU, HÜSEYİN, AKBULUT, HÜSEYİN, ÇİPE, GÖKHAN, BOZKURT, SÜLEYMAN, AKÇAKAYA, ADEM, MÜSLÜMANOĞLU, MAHMUT, MALYA, FATMA ÜMİT, ERSOY, YELIZ EMINE, KADIOĞLU, HÜSEYİN, AKBULUT, HÜSEYİN, BOZKURT, SÜLEYMAN, AKÇAKAYA, ADEM
The role of PET/CT in detection unexpected distant metastasis in rectal cancer:case report
2012-11-24, ÇİPE, GÖKHAN, BEKTAŞOĞLU, HÜSEYİN KAZIM, KADIOĞLU, HÜSEYİN, ERSOY, YELİZ EMİNE, MEMMİ, NAİM, AKÇAKAYA, ADEM, KARATEPE, OĞUZHAN, MÜSLÜMANOĞLU, MAHMUT, BEKTAŞOĞLU, HÜSEYİN KAZIM, KADIOĞLU, HÜSEYİN, ERSOY, YELIZ EMINE, MEMMİ, NAİM, AKÇAKAYA, ADEM
UNUSUALLY LOCATED PROLIFERATING TRICHOLEMMAL TUMOUR: CASE REPORT
2013-09-01, KADIOĞLU, HÜSEYİN, YILDIZ, ŞEYMA, YÜCEL, Serap, ERSOY, YELİZ EMİNE, BOZKURT, SÜLEYMAN, Müslümanoğlu, Mahmut, KADIOĞLU, HÜSEYİN, YILDIZ, ŞEYMA, ERSOY, YELIZ EMINE, BOZKURT, SÜLEYMAN
Comment on: Actinomycotic Infection of the Abdominal Wall Mimicking a Malignant Neoplasm by Yi et al.
2012-12-01, Kadioglu, HÜSEYİN, Ersoy, YELİZ EMİNE, Bozkurt, SÜLEYMAN, Memmi, NAİM, CIPE, Gokhan, Gucin, ZÜHAL, MUSLUMANOGLU, Mahmut, KADIOĞLU, HÜSEYİN, ERSOY, YELIZ EMINE, BOZKURT, SÜLEYMAN, MEMMİ, NAİM, GÜCİN, ZÜHAL
Primary breast lymphoma; disease recurrence Primer meme lenfomasi{dotless}; yineleyen hastali{dotless}k
2012-09-18, Kadioǧlu, HÜSEYİN, YUCEL, Serap, GÜRAL, Zeynep, GÖZÜBÜYÜKOGLU, Nurhan, AKGÜN, Züleyha, YILDIZ, ŞEYMA, GÜCİN, ZÜHAL, Bozkurt, SÜLEYMAN, ERSOY, YELİZ EMİNE, MUSLUMANOGLU, Mahmut, SAGLAM, Esra Kaytan, KADIOĞLU, HÜSEYİN, YILDIZ, ŞEYMA, GÜCİN, ZÜHAL, BOZKURT, SÜLEYMAN, ERSOY, YELIZ EMINE
Breast Metastasis of Alveolar Soft Part Sarcoma
2016-10-01, AKBULUT, HÜSEYİN, BEKTAŞOĞLU, Hüseyin, BAŞKÖY, LÜTFULLAH, MALYA, FATMA ÜMİT, KADIOĞLU, HÜSEYİN, GÜCİN, ZÜHAL, ERSOY, YELİZ EMİNE, AKBULUT, HÜSEYİN, BAŞKÖY, LÜTFULLAH, MALYA, FATMA ÜMİT, KADIOĞLU, HÜSEYİN, GÜCİN, ZÜHAL, ERSOY, YELIZ EMINE