Person:
CENGİZ, FATMA PELIN

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Kurumdan Ayrılmıştır

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Organizational Unit

Tıp Fakültesi

First Name

FATMA PELIN

Last Name

CENGİZ

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Now showing 1 - 10 of 13

Open Access
The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population
(2019-01-01T00:00:00Z) ONSUN, NAHİDE; Pirmit, Serpil; Ozkaya, Dilek; Çelik, Şirin; Rezvani, Aylin; CENGİZ, Fatma Pelin; Kekik, Cigdem; ONSUN, NAHIDE; REZVANİ, AYLİN; CENGİZ, FATMA PELIN
Background. Psoriasis is a multifactorial immune-mediated infammatory disease triggered by both genetic and environmental factors. Te strong association between psoriasis and HLA-C∗06 allele has been demonstrated in various races. Te HLAC∗12 allele is closely related to the HLA-C∗06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C∗12 and psoriasis in the Turkish population. Te present study aims to determine this relationship. Methods. Tis case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C∗06, HLA-C∗12, and HLA-C∗04 alleles were most commonly observed in psoriasis patients. HLA-C∗06 and HLA-C∗12 were signifcantly more frequent in the psoriasis group. HLA-C∗06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C∗12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C∗12 allele. Conclusions. HLA-C∗12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.
Open Access
Dermoscopic Features of Small, Medium, and Large-Sized Congenital Melanocytic Nevi
(2017-02-01) Cengiz, FATMA PELİN; Emiroglu, NAZAN; OZKAYA, Dilek Biyik; Onsun, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Background: Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma. Objective: To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. Methods: A nonrandomized observational study was performed. A total of 108 melanocytic nevi were analysed by clinical and dermoscopic examination. Results: Of the subjects, 57.4% were aged less than 16 years, 42.6% were aged 16 and more. Of the nevi, 26 had reticular pattern (24.1%), 35 had globular pattern (32.4%), 13 had reticular-globular pattern (12.0%), 16 had homogeneous pattern (14.8%), 6 had reticular-homogeneous pattern (5.6%), 2 had globular-homogeneous pattern (1.9%), 7 had cobblestone pattern (6.5%), 3 had reticular patchy pattern (2.8%). Atypical dots and globules, focal hypopigmentation and perifollicular hypopigmentation are the most common dermoscopic features of CMN. The rarest dermoscopic feature is the blue-whitish veil. Conclusion: Most of the dermoscopic features related with dysplastic nevi up to the present, such as atypical dots and globules, focal hypopigmentation, perifollicular hypopigmentation were observed in CMN, in our study. Congenital nevus and dysplastic nevi may share the same dermoscopic features, therefore it is important to know it is found at birth or not.
Open Access
Frequency and risk factors for secondary malignancies in patients with mycosis fungoides
(2016-08-01) EMIROGLU, NAZAN; CENGIZ, F. P.; BAHALI, A. Gulsel; Su, O.; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), has an incidence of 6.4 per million people [1]. Patients with CTCL have an increased risk of the development of secondary malignancies, particularly lymphomas [2,3]. We conducted a 20-year population-based cohort study to assess the risk factors of secondary cancers in MF patients from our center.
Open Access
Dermatoscopic findings of pigmented purpuric dermatosis
(2016-09-01) Su, Ozlem; OZKAYA, Dilek Biyik; Emiroglu, NAZAN; Cengiz, FATMA PELİN; Bahali, ANIL GÜLSEL; Yildiz, PELİN; DEMIRKESEN, Cuyan; Onsun, NAHİDE; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; CENGİZ, FATMA PELIN; BAHALI, ANIL GÜLSEL; YILDIZ, PELİN; ONSUN, NAHIDE
ackground:: Pigmented purpuric dermatosis is a chronic skin disorder of unknown aetiology characterised by symmetrical petechial and pigmented macules, often confined to the lower limbs. The aetiology of pigmented purpuric dermatosis is unknown. Dermatoscopy is a non-invasive diagnostic technique that allows the visualisation of morphological features invisible to the naked eye; it combines a method that renders the corneal layer of the skin translucent with an optical system that magnifies the image projected onto the retina. Objectives:: The aim of this study is to investigate the dermatoscopic findings of pigmented purpuric dermatosis. Methods:: This study enrolled patients diagnosed histopathologically with pigmented purpuric dermatosis who had dermatoscopic records. We reviewed the dermatoscopic images of PPD patients who attended the outpatient clinic in the Istanbul Dermatovenereology Department at the Bezmialem Vakıf University Medical Faculty. Results:: Dermatoscopy showed: coppery-red pigmentation (97%, n = 31) in the background, a brown network (34%, n = 11), linear vessels (22%, n = 7), round to oval red dots, globules, and patches (69%, n = 22; 75%, n = 24; 34%, n = 11; respectively), brown globules (26%, n = 8) and dots (53%, n = 17), linear brown lines (22%, n = 7), and follicular openings (13%, n = 4). Conclusion:: To our knowledge, this is the first study to report the dermatoscopy of pigmented purpuric dermatosis. In our opinion, dermatoscopy can be useful in the diagnosis of pigmented purpuric dermatosis.
Open Access
Which dermatology patients attend to Dermatology Outpatient Clinics during the SARS-CoV-2 outbreak in Turkey and what happened to them?
(2020-05-11T04:00:00Z) CENGİZ, Fatma Pelin; EMİROĞLU, Nazan; BAHALI, ANIL GÜLSEL; DİZMAN, DİDEM; TAŞLIDERE, NAZAN; MERT, Ömer; Akarslan, Tahsin Cagdas; Gunes, Begum; KÜÇÜK, Özlem Su; ONSUN, Nahide; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; BAHALI, ANIL GÜLSEL; DİZMAN, DİDEM; TAŞLIDERE, NAZAN; GÜNEŞ, BEGÜM; MERT, ÖMER; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Coronavirus disease, first emerged in Wuhan, rapidly spread all over the world since December 2019. There are concerns about elective dermatology appointments and its results. Herein, we aimed to find out which type of dermatologic patients attended to dermatology outpatient clinic. The patients visiting the clinics for elective dermatologic diseases between March 11 and 18, 2020, were included in this study. Their age, sex, diagnosis of disease, requirement for emergent intervention, and their medical records about COVID-19 were obtained. There were 390 patients attending to the dermatology outpatient clinic in this period. The most common disease was acne (N: 94, 24%), only 19% of patients need emergent interventions or dose adjustment. There were 40 (10%) patients over the age of 65. After their visits, five patients were diagnosed as COVID-19 in 2weeks. Dermatologic examinations may be a vector for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission since being closed to the patient. Five of our patients were diagnosed as COVID-19 after their elective visit to hospital. Since the asymptomatic course of some young patients, most of our patients were not screened for COVID-19. Our findings support the concerns of elective physician examinations.
Open Access
Acne located on the trunk, whey protein supplementation: Is there any association?
(2017-03-05) CENGIZ, FATMA PELİN; Cevirgen, Cemil; EMIROGLU, NAZAN; Gulsel, Bahali; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; BAHALI, ANIL GÜLSEL; ONSUN, NAHIDE
Whey protein is a source of protein that was isolated from milk. Whey proteins are composed of higher levels of essential amino acids. The role of diet in acne etiology has been investigated for several years. It was established that milk and milk products can trigger acneiform lesions, and recent evidence supports the role of whey protein supplements in acne. Herein, we report 6 healthy male adolescent patients developing acne located only to the trunk after the consumption of whey protein supplements for faster bodybuilding. This is the first observation which specified the location of acneiform lesions among bodybuilders. In our opinion, a trendy and common health problem is beginning among adolescents in the gyms.
Open Access
Evaluation of mean platelet volume in localized scleroderma
(2017-09-01) Bahali, ANIL GÜLSEL; Su, Ozlem; Emiroglu, NAZAN; Cengiz, FATMA PELİN; Kaya, MEHMET ONUR; Onsun, NAHİDE; BAHALI, ANIL GÜLSEL; SU KÜÇÜK, ÖZLEM; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN; KAYA, MEHMET ONUR; ONSUN, NAHIDE
Abstract: Background: Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation. Objectives: To evaluate whether there was any relation between localized scleroderma and platelet parameters. Methods: Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects. Results: The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p<0.001). There was no significant difference in the platelet counts between the two groups (p= 0.560) In the patient group, there was no significant relation between the mean platelet volume levels and clinical signs of disease (p=0.09). However, plateletcrit values are higher in generalized than localized forms of disease (p=0.01). Study Limitations: The limited number of patients and the retrospective nature of the study were our limitations. Conclusions: This study suggests that platelets might play a role in the pathogenesis of scleroderma. Platelet parameters may be used as markers for evaluating disease severity and inflammatory processes. Thus, there is a need for more detailed and prospective studies. Keywords: Blood platelets; Scleroderma, localized; Transforming growth factor beta
Open Access
Effectiveness of the Capparis spinosa Treatment in Vitiligo
(2018-02-01T00:00:00Z) EMİROĞLU, NAZAN; CENGİZ, FATMA PELİN; BAHALI, ANIL GÜLSEL; BIYIK ÖZKAYA, DİLEK; SU KÜÇÜK, ÖZLEM SU; ONSUN, NAHİDE; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN; BAHALI, ANIL GÜLSEL; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Open Access
Evaluation of Mean Platelet Volume in Patients with Pigmented Purpuric Dermatosis
(2017-01-01) Su, Ozlem; Bahali, ANIL GÜLSEL; OZKAYA, Dilek Biyik; Cengiz, FATMA PELİN; Emiroglu, NAZAN; Kaya, MEHMET ONUR; Onsun, NAHİDE; BAHALI, ANIL GÜLSEL; BIYIK ÖZKAYA, DİLEK; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; KAYA, MEHMET ONUR; ONSUN, NAHIDE
Objective: Pigmented purpuric dermatosis (PPD) is a chronic skin disease characterized by petechial and pigmentary macules. The etiology of the disease remains unknown. Mean platelet volume (MPV) is a marker of platelet (PLT) function and activation. PLTs play important roles in inflammation and innate and adaptive immunity in addition to their roles in hemostasis and thrombosis. In this study, we investigated the possible association between MPV and PPD.
Open Access
Birt-Hogg-Dube Syndrome
(2018-07-01T00:00:00Z) EMİROĞLU, Nazan; CENGİZ, Fatma Pelin; TOSUNER, ZEYNEP; BAHALI, ANIL GÜLSEL; ONSUN, Nahide; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN; TOSUNER, ZEYNEP; BAHALI, ANIL GÜLSEL; ONSUN, NAHIDE
Birt-Hogg-Dube syndrome is characterized by cutaneous findings, including fibrofolliculomas, angiofibromas, fibroepithelial polyps, and trichodiscomas. It is an inherited autosomal dominant disorder. This syndrome also includes extra-cutaneous findings, such as pulmonary cysts, spontaneous pneumothorax, and renal cancer. Because of the systemic involvement, early diagnosis and treatment are important. Here, we report the case of a 53-year-old man diagnosed as having Birt-Hogg-Dube syndrome.