Person: YANIKOĞLU, RABİA SARE
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Publication The Caenorhabditis elegans Life-Span Activity of Trigonella foenum-graecum Seed Extracts(2023-10-08) Yanartaş A.; Güleç M.; Yanıkoğlu R. S.; Göç F.; Alim Toraman G. Ö.; Topçu G.; YANIKOĞLU, RABİA SARE; GÖÇ, FATMA; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIPublication Evaluation of Metabolites Produced by Fungal Biotransformation of Apigenin and Fisetin and Their Cytotoxic Activities(2020-03-01T00:00:00Z) GAZİOĞLU, IŞIL; Erdoğan, Oğuz; YANIKOĞLU, RABİA SARE; ÖZTÜRK, DİLEK; GAZİOĞLU, IŞIL; YANIKOĞLU, RABİA SARE; ÖZTÜRK CİVELEK, DİLEKPublication Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance(2023-12-01) GÜNAYDIN AKYILDIZ, AYŞENUR; Yanikoglu R. S.; Gulec M.; ALİM TORAMAN, GÜLBAHAR ÖZGE; Kuran E. D.; Atasoy S.; Olgun A.; Topcu G.; TOPÇU, GÜLAÇTI; ATASOY, SEZEN; GÜNAYDIN AKYILDIZ, AYŞENUR; ALİM TORAMAN, GÜLBAHAR ÖZGE; YANIKOĞLU, RABİA SAREBackground: Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action of wound healing is not fully understood. The MAP kinase family, which plays an active role in wound healing, is a well-characterized large family of serine/threonine kinases and regulates processes such as proliferation, oncogenesis, differentiation, and inflammation in the cell. The aim of this study is to comparatively elucidate the mechanisms of action of emodin and aloe-emodin, which are potential agents in wound healing. Methods: The mechanism of the effects of emodin and aloe-emodin on cell viability and cell migration was examined using the human skin fibroblast (CCD-1079Sk) cell line. The gene expression levels of the MAP kinases (JNK, P38, ERK) in the skin fibroblast cells along with a molecular docking study analyzing their interaction potential were evaluated. Furthermore, the molecules’ effects on the lifespan of Caenorhabditis elegans were studied. Results: Emodin and aloe-emodin inhibited the ATP content of the cells in a concentration dependent manner and accelerated cell migration at the lower concentrations while inhibiting cell migration in the higher concentration treatment groups. The expressions of JNK and P38 were upregulated at the low concentrations and downregulated at the higher concentrations. The molecular docking studies of the molecules gave high docking scores indicating their interaction potential with JNK and P38. C. elegans lifespan under heat stress was observed longer after 75 µM emodin and was significantly reduced after 150 µM aloe-emodin treatment. Conclusion: Aloe-emodin was found to be more potent on cell viability, cell migration, gene expression levels of the MAP kinases in healthy fibroblastic skin cells, and on the lifespan of C. elegans. This study reveals the functional effects and the biological factors that interact in the wound healing process of emodin and aloe-emodin, and give a possible treatment alternative to shorten the duration of wound care.Publication Antioxidant activities of novel eugenol derivatives substituted carbamate(2015-11-29) Yanıkoğlu, RABİA SARE; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; Sonmez, Fatih; YANIKOĞLU, RABİA SARE; ZENGİN KURT, BELMA; GAZİOĞLU, IŞILPublication Onosma ambigens Lacaita: Evaluation of Cholinesterase Inhibitory Activity(2024-04-05) Göç F.; Alim Toraman G. Ö.; Yanıkoğlu R. S.; Demirel F.; Uluocak B.; Pakkan H.; Başoğlu K.; Selvi B.; Topçu G.; GÖÇ, FATMA; ALİM TORAMAN, GÜLBAHAR ÖZGE; YANIKOĞLU, RABİA SARE; TOPÇU, GÜLAÇTIPublication Biological activities of extracts from Lavandula officinalis and Valeriana officinalis: Immunoregulation and cytotoxicity evaluation(2020-10-07T00:00:00Z) YANIKOĞLU, RABİA SARE; ATASOY, SEZEN; DİNCEL, DEMET; KAPTAN, EYLÜL ZEYNEP; DAĞ, AYDAN; YANIKOĞLU, RABİA SARE; ATASOY, SEZEN; DİNCEL, DEMET; DAĞ, AYDANPublication A review of the currently developed analytical methods for the determination of biogenic amines in food products(2023-01-01T00:00:00Z) TIRIS, GİZEM; Sare Yanıkoğlu, RABİA SARE; Ceylan, Burhan; EGELİ, DERYA; Kepekci Tekkeli, Evrim; ÖNAL, Armağan; TIRIS, GİZEM; YANIKOĞLU, RABİA SARE; EGELİ, DERYA© 2022Biogenic amines (BAs) are group of substances that are formed from amino acids by decarboxylation or amination and transamination of aldehydes and ketones. They may have either aliphatic, aromatic or heterocyclic structure. Their quantity determines their effects, optimum amounts are essential for physiological functions, but excess of BAs causes various toxic effects through out human body. BAs are presented in a wide variety of fermented foods such as fish, meat, milk products and some kinds of beverages like wine, beer and some fruit juices. In order to quantify their intake by food products are important, the methods that provide determination of BAs in food products are a matter of priority. Mostly, liquid chromatographic (LC) methods are preffered. Their amine groups are able to be derivatized by so many fluorogenic reagents. It is possible to combine LC systems with UV–vis. absorption spectrometric, fluorimetric and mass spectrometric detectors. Due to the fact that BAs are important markers for food quality and important for health, in this article LC methods for the determination of BAs in foods were reviewed from 2012 to present.