Person: ŞENTÜRK, HAKAN
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Publication Metadata only Human In Vitro Disease Models: Dawning a New Era Away from Animal Models(2016-09-01T00:00:00Z) Senturk, HAKAN; ŞENTÜRK, HAKANPublication Metadata only Role of Serum and Biliary CEA, CA19-9, VEGFR-3 and TAC for Differentation of Malignant and Benign Biliary Obstruction(2014-05-01) Ince, ALİ TÜZÜN; YILDIZ, Kemal; BAYSAL, Birol; DANALIOGLU, Ahmet; KOCAMAN, Orhan; TOZLU, Mukaddes; GANGARAPU, Venkatanarayana; KEMIK, Ahu Sarbay; UYSAL, Oemer; Senturk, HAKAN; İNCE, ALİ TÜZÜN; UYSAL, ÖMER; ŞENTÜRK, HAKANPublication Metadata only The Effect of Helicobacter pylori Infection on the Development of Splenic Vein Thrombosis in Chronic Pancreatitis Patients(2012-05-01T00:00:00Z) Sisman, Gurhan; Erzin, Yusuf; Senturk, HAKAN; ŞENTÜRK, HAKANPublication Metadata only Is alanine aminotransferase level a surrogate biomarker of hepatic apoptosis in nonalcoholic fatty liver disease?(2010-04-01T00:00:00Z) Canbakan, Billar; Senturk, HAKAN; Canbakan, Mustafa; TOPTAŞ, TAYFUR; Tabak, Omur; Balci, Hurtye; OLGAÇ, Necat Vakur; Ozbay, Guisen; ŞENTÜRK, HAKANAim: To evaluate the serum alanine aminotransferase (ALT) variabilities in nonalcoholic fatty liver disease (NAFLD) and correlate it with hepatocyte apoptosis and oxidative stress parameters. Methods: 24 patients with NAFLD and normal ALT were compared with 26 subjects with NAFLD and elevated ALT. Liver oxidative stress was estimated on the basis of malondialdehyde, superoxide dismutase and glutathione. Immunohistochemistry was performed for activated caspase 3 and 8, nuclear factor-kappa B, antiapoptotic Bcl-2 protein and serum TNF receptor levels were measured. Results: The mean caspase 3 and 8 activity scores, oxidative stress parameters, necroinflammatory grade and prevalence of severe fibrosis were comparable across the groups with normal versus elevated ALT. Patients with nonalcoholic steatohepatitis had significantly higher caspase 3 and 8 activity (percentage of cells with positive staining per high power field), and serum malondialdehyde (mmol/l) levels than those with simple steatosis. ALT elevation was not a risk factor for advanced necroinflammatory grade and fibrosis. A receiver operating characteristic curve did not demonstrate sensitivity and specificity for discriminative power of ALT. Conclusion: Apoptosis and oxidative stress are the main processes contributing to disease progression in NAFLD. ALT values do not correlate with the parameters of apoptosis and oxidative stress. The disease severity can only be determined by liver biopsy.Publication Metadata only A randomized controlled trial of home monitoring versus hospitalization for mild non-alcoholic acute interstitial pancreatitis: A pilot study(2014-05-01) Ince, ALİ TÜZÜN; Senturk, HAKAN; Singh, Vikesh K.; YILDIZ, Kemal; DANALIOGLU, Ahmet; CINAR, Ahmet; Uysal, Omer; KOCAMAN, Orhan; BAYSAL, Birol; Guerakar, Ahmet; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; UYSAL, ÖMERBackground/Objectives: Acute pancreatitis (AP) is a disease typically requiring in-hospital treatment. We conducted a trial to assess the feasibility of early discharge from the hospital for patients with mild nonalcoholic acute pancreatitis (NAAP).Publication Metadata only Validation of Biochemical Markers for the Prediction of Liver Fibrosis and Activity in Hemodialysis Patients With Chronic Hepatitis C(2010-05-01T00:00:00Z) Senturk, HAKAN; Canbakan, Mustafa; Canbakan, Billur; HATEMİ, Ali İbrahim; Toptas, Tayfur; Tabak, Omur; Ozaras, Resat; Tabak, Fehmi; Balci, Huriye; Ozbay, Gulsen; ŞENTÜRK, HAKANPublication Metadata only Efficacy of Rifaximin on Circulating Endotoxins and Cytokines in Patients With Non-Alcoholic Fatty Liver(2015-04-01) Gangarapu, Venkatanarayana; Ince, Ali T.; BAYSAL, Birol; KAYAR, Yusuf; Senturk, HAKAN; KILIC, Ulkan; GOK, Ozlem; Uysal, Oemer; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; UYSAL, ÖMERPublication Metadata only Comparison of LMA® Gastro™ airway and gastrolaryngeal tube in endoscopic retrograde cholangiopancreatography: a prospective randomized observational trial(2021-05-13T00:00:00Z) Uysal, Harun; Senturk, HAKAN; Calim, Muhittin; Daskaya, Hayrettin; Guney, Ibrahim A; Karaaslan, Kazim; UYSAL, HARUN; ŞENTÜRK, HAKAN; DAŞKAYA, HAYRETTİNBackground: New generation airway devices with different designs have been developed as an alternative to endotracheal intubation in order to avoid adverse events associated with sedation in endoscopic procedures and to provide patent airway. We aimed to compare two supraglottic airway devices (SGADs), the LMA® Gastro™ airway and gastrolaryngeal tube (GLT), in terms of airway efficiency, performance during procedure and adverse events in endoscopic retrograde cholangiopancreatography (ERCP). Methods: A hundred-three ERCP patients without high risk of aspiration were included. Patients were randomly allocated to the LMA Gastro and GLT groups. The primary study outcomes were the comparison of the two SGADs in terms of oropharyngeal leak pressure (OLP). Secondary study outcome was SGADs-related adverse events. Results: Procedures were completed with SGADs in fifty patients in each group. The rate of successful insertion at first attempt was 72% in GLT and 96% in LMA Gastro (P=0.004). The mean OLP of LMA Gastro Group (31.8 cmH2O) was significantly higher than that of the GLT Group (26.5 cmH2O), (P=0.0001). However, endoscopists' satisfaction was higher in GLT (P=0.0001). Mucosal damage and sore throat were lower in LMA Gastro Group. Conclusions: LMA® Gastro™ had a higher OLP than GLT. However, GLT was better for endoscopist satisfaction, as it provides more satisfying maneuverability. As to secondary outcome advers events were lower in LMA® Gastro™. The lower complication rates associated with the device and providing a more patent airway also highlighted the apparent clinical efficacy of LMA® Gastro™ than GLT, in ERCP.Publication Metadata only Long-Term Effect of Interferon Therapy in Patients with HBeAg Positive Chronic Hepatitis B Infection(2011-01-01T00:00:00Z) Senturk, HAKAN; Baysal, Birol; Tahan, Veysel; Zerdali, Hasan; Ozaras, Resat; Tabak, Fehmi; Mert, Ali; Canbakan, Billur; Tabak, Omur; Ozbay, Gulsen; ŞENTÜRK, HAKANIntroduction Several studies have reported that interferon therapy increases elimination rate of HBeAg and anti-HBe seroconversion in chronic hepatitis B (CHB) patients. We aimed to evaluate long-term results of interferon-alpha treatment in HBeAg positive CHB patients in a country with exclusively D genotype.Publication Open Access Comparison of tomographic and colonoscopic diagnoses in the presence of colonic wall thickening(2014-01-01) Ince, ALİ TÜZÜN; BAYSAL, Birol; KAYAR, Yusuf; Arabaci, ELİF; Bilgin, MEHMET; HAMDARD, Jamshid; YAY, Adnan; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ARABACI, ELİF; BİLGİN, MEHMET; ŞENTÜRK, HAKANIntroduction and objective: Colonic wall thickening is a common condition in a number of benignant and malignant diseases. This study investigated the accuracy of radiological diagnoses in patients diagnosed with colonic wall thickening using multislice CT (MDCT). Materials and method: Files of patients with colonic wall thickening diagnosed with 64-slice MDCT were reviewed retrospectively. The colonoscopy results of these patients were grouped under neoplastic process (cancer and adenomatous polyp), inflammatory bowel disease (IBD), diverticulitis and other etiology (nonspecific events, ischemic colitis, solitary rectal ulcer, external compression, secondary to volvulus and radiotherapy), and the results were statistically evaluated. p values < 0.05 were considered statistically significant. Results: The study was performed on 505 files (290 males [57.4%], 215 females [42.6%], mean age: 49.15 ± 18.4 years). CT and colonoscopic diagnoses were reviewed and the following CT to colonoscopy ratios was observed: neoplastic process: 44.4% vs. 40.2%; IBD: 42.4% vs. 42.4%; diverticulitis: 4% vs. 4.2%; other etiology: 9.3% vs. 3.2%. Colonoscopy failed to identify pathology in 9.9% of the patients. The sensitivity, specificity, PPV, NPV and accuracy of CT were 95.6%, 90.4%, 87.1%, 96.8% and 92.4%, respectively, in detecting neoplastic processes; 97.2%, 97.9%, 97.2%, 97.9% and 97.6%, respectively, in detecting IBD; 90.5%, 99.8%, 95%, 99.6% and 99.4%, respectively, in detecting diverticulitis, and 50%, 96,7%, 62.5%, 94.6% and 92%, respectively, in detecting other etiology. Conclusion: While, accuracy of 64 slice-CT in diagnosing colonic wall thickenings secondary especially to neoplastic processes, IBD and diverticulitis was significantly higher, but differential diagnosis is challenging in pathologies due to other etiologies.