Person: ŞENTÜRK, HAKAN
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Publication A randomized controlled trial of home monitoring versus hospitalization for mild non-alcoholic acute interstitial pancreatitis: A pilot study(2014-05-01) Ince, ALİ TÜZÜN; Senturk, HAKAN; Singh, Vikesh K.; YILDIZ, Kemal; DANALIOGLU, Ahmet; CINAR, Ahmet; Uysal, Omer; KOCAMAN, Orhan; BAYSAL, Birol; Guerakar, Ahmet; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; UYSAL, ÖMERBackground/Objectives: Acute pancreatitis (AP) is a disease typically requiring in-hospital treatment. We conducted a trial to assess the feasibility of early discharge from the hospital for patients with mild nonalcoholic acute pancreatitis (NAAP).Publication Rate and Predictors of Endoscopic Mucosal Healing in Biologic Naive Patients with Inflammatory Bowel Disease by Azathioprine Treatment: A Real World, 10 Years- Experience from a Single Centre in Turkey.(2016-08-01T00:00:00Z) Basaranoglu, METİN; Ertan, A; Mathew, S; Senturk, H; Ala, A; Demirbag, AE; BAŞARANOĞLU, METİN; ŞENTÜRK, HAKANBackground: There is increasing evidence that endoscopic mucosal healing (EMH) is a key target in inflammatory bowel disease (IBD) therapy. However, there is limited evidence of EMH rates with conventional IBD therapy outside of Western population groups. Ai̇m: To evaluate the role of azathioprine (AZA) in inducing EMH in IBD patients. Methods: Patients with inflammatory bowel disease were evaluated in terms of endoscopic mucosal healing and the incidence of surgical interventions during the azathioprine treatment between 1995 to 2014. Results: A total of 120 inflammatory bowel disease patients were enrolled. Endoscopic mucosal healing was found in 37% patients with inflammatory bowel disease (42% in chronic ulcerative colitis and 33% in Crohn's disease). Male gender had a negative impact on the efficacy of azathioprine (P<0.05). Responder inflammatory bowel disease patients were older (age at the IBD diagnose) than the nonresponder (P<0.05). Azathioprine therapy reduced the number of the surgical interventions (P<0.05). Conclusi̇on: We showed that azathioprine therapy significantly induced endoscopic mucosal healing in biologic naïve patients with active inflammatory bowel disease as well as decreasing the surgical interventions, with negative predictive factors identified by a younger age at IBD presentation and male gender.Publication The evaluation of cellular and humoral immunity characteristics in gastrointestinal and hepatocellular cancers(2014-06-25T00:00:00Z) TÜRKDOĞAN, MEHMET KÜRŞAT; KIZILTAN, HÜRİYE ŞENAY; GÜNEŞ BAYIR, AYŞE; KAYAR, YUSUF; ŞENTÜRK, HAKAN; İNCE, ALİ TÜZÜN; KOCAMAN, ORHAN; Danalıoğlu, Ahmed; KIZILTAN, HURİYE ŞENAY; GÜNEŞ BAYIR, AYŞE; ŞENTÜRK, HAKAN; İNCE, ALİ TÜZÜNPublication Low Molecular Weight Heparin Treatment of Acute Severe Pancreatitis: A Randomized, Controlled Study(2015-04-01) TOZLU, Mukaddes; KAYAR, Yusuf; BAYSAL, Birol; Ince, ALİ TÜZÜN; KOCAMAN, Orhan; DANALIOGLU, Ahmet; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKANPublication Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit(2018-11-01) kayar, yusuf; Baysal, Birol; Tozlu, Mukaddes; ŞENTÜRK, hakan; Atay, Musa; İNCE, ALİ TÜZÜN; ŞENTÜRK, HAKAN; İNCE, ALİ TÜZÜNBackground: While acute pancreatitis (AP) resolves spontaneously with supportive treatment in most patients, it may be life-threatening. Predicting the disease severity at onset dictates the management strategy. We aimed to define the patients with mild pancreatitis who may be considered for outpatient management with significant cost-savings. Materials and Methods: This prospective observational study included 180 patients with mild AP according to the harmless acute pancreatitis score (HAPS) and Imrie score. The relationships of biochemical parameters with the changes in the Balthazar score and clinical course were examined. Results: The study included 180 patients (111 females, 69 males; mean age: 53.9 ± 17.2 years; range: 17–92 years). The etiology was biliary in 118 (65%) patients and remained undetermined in 38 (21.1%) patients. Computed tomography (CT) performed within the first 12 h revealed mild and moderate AP in 159 (88.3%) and 21 (11.7%) patients, respectively. CT repeated at 72 h revealed mild, moderate, and severe AP in 155 (86.1%), 24 (13.3%), and 1 (0.6%) patients, respectively. Comparisons between stages A + B + C and D + E showed significant differences in the amylase levels on day 1 and 3, and in C-reactive protein on day 3. Also, in stage D and E disease, narcotic analgesic intake, oral intake onset time, and pain were significantly higher. Conclusion: There were no significant changes in the CT findings of patients with mild AP at 12 and 72 h. Most patients (n = 179; 99.4%) recovered uneventfully. Patients with mild pancreatitis according to the HAPS and Imrie scores can be considered for outpatient management. The recovery is longer in stage D and E disease.Publication Müsinöz Pankreas Kist Alt Guruplarında Kist Boyutlarının Ve Kist Sıvı Viskozitesinin Malignite Açısından Belirleyiciliği Var Mıdır ?(2021-09-20T00:00:00Z) KÖKER, İBRAHİM HAKKI; ŞENTÜRK, HAKAN; KÖKER, İBRAHİM HAKKI; ŞENTÜRK, HAKANPublication Results of nucleos(t)ide analog treatment discontinuation in hepatitis b e-Antigen-negative chronic hepatitis b: Nucstop study(2024-01-01) Kiremitci S.; Kochan K.; SEVEN G.; Keskin E. B.; OKAY G.; AKKOYUNLU Y.; Koc M. M.; SÜMBÜL B.; ŞENTÜRK H.; KİREMİTÇİ, SERCAN; KOÇHAN, KORAY; SEVEN, GÜLSEREN; OKAY, GÜLAY; AKKOYUNLU, YASEMİN; SÜMBÜL, BİLGE; ŞENTÜRK, HAKANBackground/Aims: This study aims to investigate the effects of nucleos(t)ide analogs (NAs) discontinuation in eligible patients in accordance with the Asian Pacific Association for the Study of the Liver hepatitis B guideline and the factors affecting clinical and virological relapses. Materials and Methods: In this prospectively designed study, hepatitis B e antigen (HBeAg)-negative chronic hepatitis B patients who were followed up between 2012 and 2019 were evaluated and 57 patients were included. All participants enrolled the study were HBeAgnegative status at NA initiation. Results: The median age of the patients was 49 (29-72) years and 24 (42%) were females. The median treatment duration was 96 (36-276) months and patients were followed for a median duration of 27 months. Sixteen patients had a previous history of NA switch, and thirteen of these patients had a history of lamivudine resistance. Thirty-eight of 57 patients (66%) developed an elevated hepatitis B virus deoxyribonucleic acid level of 2000 IU/mL at least once, defined as virological relapse and 23 (60%) of them, experienced clinical relapse. Thirty-one of 57 patients were re-Treated during the follow-up, and hepatitis B surface antigen (HBsAg) loss occurred among 4 (7%) patients. All patients who experienced HBsAg loss had a history of lamivudine resistance (P = .002). Conclusion: Despite receiving NAs suppression therapy for a long time, HBsAg loss occurs rarely. Although it was not life-Threatening, most patients experienced relapses and treatment should be restarted. In our study, whether it is a coincidence that all patients with HBsAg loss are patients in whom NAs are used sequentially due to lamivudine resistance is an issue that needs to be further investigated.Publication Pankreas kistlerinin değerlendirilmesinde Probe -based confocal laser endomikroskopi tanıya katkıda bulunuyor mu?(2017-12-06T00:00:00Z) ŞENTÜRK, HAKAN; KÖKER, İBRAHİM HAKKI; BİBERCİ KESKİN, ELMAS; İNCE, ALİ TÜZÜN; ÜNVER, NURCAN; ARICI, DİLEK SEMA; ŞENTÜRK, HAKAN; KÖKER, İBRAHİM HAKKI; BİBERCİ KESKİN, ELMAS; İNCE, ALİ TÜZÜNPublication Leptin Profile and Insulin Resistance Modulate Hepatocyte Apoptosis and Fibrosis in Non-Alcoholic Fatty Liver Disease(2014-05-01T00:00:00Z) Canbakan, Billur; Senturk, HAKAN; Tuncer, Murat; Koroglu, Emine; Atay, Kadri; Kepil, Nuray; SONSUZ, Abdullah; ŞENTÜRK, HAKANPublication PRESENCE OF ONLY WILDTYPE VIRUS IS THE STRONGEST DETERMINANT OF HBVDNA UNDETECTABILITY AND HBSAG CLEARANCE IN HBEAG-POSITIVE CHRONIC HEPATITIS B PATIENTS TREATED WITH PEGINTERFERON(2012-04-01T00:00:00Z) Sonneveld, M. J.; Rijckborst, V.; Zeuzem, S.; Heathcote, E. J.; Simon, K.; ŞENTÜRK, HAKAN; Pas, S. D.; Hansen, B. E.; Janssen, H. L.; ŞENTÜRK, HAKAN