Person: DOĞAN, REMZI
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Publication Open Access Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.(2020-11-01T00:00:00Z) Doğan, R; Hafız, AM; Gucin, Z; Ozer, OF; Ozturan, O; Yenigun, Alper; DOĞAN, REMZI; GÜCİN, ZÜHAL; ÖZER, ÖMER FARUK; YENİGÜN, ALPER; ÖZTURAN, ORHANPublication Open Access Dry Eye and Dry Nose Caused by the Effect of Allergic Rhinitis on Tear and Nasal Secretion Osmolarity.(2020-03-17T00:00:00Z) Elbay, A; Yenigun, A; Ozturan, O; Bayraktar, H; Ozer, Ömer Faruk; Dogan, R; YENİGÜN, ALPER; ELBAY, AHMET; ÖZDEM, ABDULLAH; ÖZER, ÖMER FARUK; DOĞAN, REMZI; ÖZTURAN, ORHANObjective: Allergic rhinitis is a type 1 hypersensitivity reaction of immunoglobulin E in the rhino-ocular mucosa. This study was planned to demonstrate in patients with allergic rhinitis to evaluate changes in tear, nasal secretions, and blood osmolarity compared to healthy individuals. Method: Forty allergic rhinitis patients, 25 patients with acute upper respiratory tract infections, and 26 healthy participants were included in the study. Positive patients with allergic symptoms and skin prick test results were included in the allergic rhinitis group. Tear, nasal secretion, and blood osmolarity values were examined for the 3 groups. Result: In patients with allergic rhinitis, tear and nasal secretion osmolarity values were significantly higher in patients with acute upper respiratory tract infections and those of the healthy participants (P ¼ .001, P ¼ .038). In blood osmolarity measurements, there was no statistical difference between the groups (P ¼ .489). In patients with allergic rhinitis, Schirmer test results were significantly shorter than patients who had acute upper respiratory tract infection and those of the healthy participants (P ¼ .001, P ¼ .001). Patients with allergic rhinitis and acute upper respiratory tract infections had significantly shorter Schirmer test results than in healthy participants (P ¼ .001, P ¼ .001). Conclusion: Tear osmolarity was increased in allergic rhinitis patients, and this was thought to lead to dry eye findings. In the presence of allergic rhinitis, nasal secretions were found more hyperosmolar than tears. Nasal secretion osmolarity was higher in allergic rhinitis patients than in patients with acute upper respiratory tract infections and control group.Publication Open Access Use of Topical Tranexamic Acid to Reduce Drainage Output After Thyroidectomy(2022-04-01T00:00:00Z) AKSOY, FADLULLAH; YENİGÜN, ALPER; YENİGÜN, Vildan Betül; Goktas, Seda Sezen; Ozdem, Abdullah; DOĞAN, Remzi; ÖZTURAN, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; YENİGÜN, VILDAN BETÜL; ÖZDEM, ABDULLAH; DOĞAN, REMZI; ÖZTURAN, ORHANObjective: Thyroid surgery is one of the frequent surgeries in daily operation schedules more often since the thyroid gland is very vascular Hematomas after thyroidectomy may cause airway obstruction, which is life-threatening and requires immediate surgical intervention. Therefore, many hemostatic devices and methods have been developed. Tranexamic acid is a synthetic lysine analog with low molecular weight. This study was planned to demonstrate the effect of intraoperative topical tranexamic acid on postoperative drainage output for thyroid surgery.Publication Open Access Investigation of the role of major respiratory viruses in the aetiology of nasal polyps using polymerase chain reaction technique(2014-04-01) YENIGUN, A.; AKSOY, FEYZA MÜBERRA; DOGAN, REMZİ; Yilmaz, F.; Ozturan, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN; YENİGÜN, VILDAN BETÜLObjective: We aimed to identify the role of major respiratory viruses in the aetiology of human nasal polyps using polymerase chain reaction technique. Methods: Thirty patients with nasal polyps and a group of 20 healthy patients (control group) were included in this study. Mucosa was obtained from the polyps of patients with nasal polyposis and from the middle turbinate of the control group patients by means of biopsy. The samples were stored at -80 °C until molecular analysis by polymerase chain reaction was carried out. Results: In the control group, the human coronavirus and human rhinovirus were diagnosed in one of the patients and the human respiratory syncytial virus in another. In the group with nasal polyposis, the influenza B virus was identified in one of the patients and the human coronavirus in another. Conclusion: The results did not demonstrate a statistically significant relationship between nasal polyposis and respiratory viruses.Publication Open Access A new approach to vocal cord leukoplakia and evaluation of proton pump ınhibitor treatment.(2019-02-01) Ozturan, ORHAN; Sezen, Goktas; ÇALıM, ÖMER FARUK; YENIGUN, A; DOGAN, REMZİ; TUGRUL, SELHATTİN; DOĞAN, REMZI; YENİGÜN, ALPER; ÇALIM, ÖMER FARUK; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİNPurpose: Our aim is identify a new approach to vocal cord leukoplakia treatment and detect to efficiency of proton pump inhibitors. Study design: Prospective, nonrandomized experimental clinical trial. Methods: A 'First Assessment Scale' was prepared. This scale included the lesion's and the patient's characteristics. Using this scale, 24 patients included to the study. 20 mg rabeprazole twice daily was applied to all patients. At the end of 3rd month, a 'Second Assessment Scale' was used and two groups created. In group 1, 19 patients were accepted to responsive for the therapy and received the same therapy. The group 2 was included five patients that accepted unresponsive to treatment and directed to surgery. All patients received the same treatment additionally 3 months. At the end of 6th month, the Reflux Symptom Index (RSI), the Reflux Finding Score (RFS) and the Red-Green-Blue (RGB) values evaluated and comparisons were made. Results: The RSI and RFS values were significantly decreased in all patients. The Red values were significantly decreased with treatment in group 1, but the Green and Blue values were not. In group 2, the RGB values were not showed the significant differences. In conclusion, seven patients (29,2%) showed complete lesion regression, 12 patients (50%) showed partial lesion regression and five patients (20,8%) showed no response to treatment. Conclusions: The proton pump inhibitor treatment may be beneficial for the selected patients. The scales that we prepared were useful for lesion assesment.Publication Open Access Letter to the editor on -The therapeutic effect of thymoquinone on acoustic trauma-induced hearing loss in rats-(2017-09-01) Yenigun, ALPER; Dogan, REMZİ; Ozturan, ORHAN; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN