Person: DOĞAN, REMZI
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Publication Metadata only Percutaneous Adjustable Closed Otoplasty for Prominent Ear Deformity(2013-03-01) Ozturan, ORHAN; Dogan, REMZİ; Eren, SABRİ BAKİ; AKSOY, Fadlullah; VEYSELLER, Bayram; ÖZTURAN, ORHAN; DOĞAN, REMZI; EREN, SABRİ BAKİ; AKSOY, FADLULLAHObjective: The aim of this study is to follow longitudinally the prominent ears treated by percutaneous adjustable closed otoplasty (PACO) and evaluate this procedure in terms of technical efficiency, recurrence, complications, and patient satisfaction.Publication Metadata only Audiological findings in pediatric perineal allergic rhinitis (house dust mite allergy) patients(2014-05-01) AKSOY, Fadlullah; Nursoy, MUSTAFA ATİLLA; Dogan, REMZİ; Ozturan, ORHAN; Eren, SABRİ BAKİ; VEYSELLER, Bayram; Ozkaya, EMİN; DEMIR, Aysegul Dogan; OZTURK, Burak; NURSOY, MUSTAFA ATİLLA; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; EREN, SABRİ BAKİ; ÖZKAYA, EMİNAllergic rhinitis is the type 1 hypersensitivity reaction of the nasal mucosa and its primary mediator is Ig E. It is most frequently observed in children and adolescents. Our purpose in this study is to investigate the impact of allergy on hearing functions in children with perineal allergic rhinitis (house dust mite allergy). 50 perineal allergic rhinitis (house dust mite allergy) patients (33 male, 17 female patients, aged between 6 and 15, average age 10.4) and 20 control patients (12 male, 8 female, aged between 6 and 15, average age 11.2) underwent high frequency pure tone audiometry, acoustic reflex, otacoustic emission (OAE) and auditory brainstem potentials to assess their auditory functions. No statistically significant difference was detected between the study group and the control group with respect to their hearing thresholds (250-16,000 Hz). No statistically significant difference was detected as a result of the comparison between the study group and control group in terms of their signal-noise ratios at Distortion Product OAE in all frequencies (996-8,004 Hz). No statistically significant difference was detected between the study group and the control group in terms of the 1st, 3rd and 5th wave latencies and 1-3, 3-5 and 1-5 inter-peak values. This study is the first study where the audiological functions of the pediatric perineal allergic rhinitis (house dust mite allergy) patients were assessed. No significant difference was detected between the group of pediatric perineal allergic rhinitis (house dust mite allergy) patients and the control group with respect to their audiological functions.Publication Metadata only Olfactory function and nasal manifestations of Behcet-s disease(2014-04-01) VEYSELLER, Bayram; Dogan, REMZİ; SU, Ozlem; AKSOY, Fadlullah; MERIC, Aysenur; Ozturan, ORHAN; DOĞAN, REMZI; AKSOY, FADLULLAH; SU KÜÇÜK, ÖZLEM; ÖZTURAN, ORHANObjective: To investigate the effect of Behcet-s disease on olfactory function, the nasal mucosa, and nasal symptoms.Publication Metadata only Protective effect of trimetazidine on amikacin-induced ototoxicity in rats(2014-04-01) AKSOY, Fadlullah; Dogan, REMZİ; Ozturan, ORHAN; VEYSELLER, Bayram; PEKTAS, Alev; HUSEYINBAS, Onder; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; EREN, SABRİ BAKİObjective: Aminoglycoside antibiotics are known to have ototoxic effects and may induce sensorineural hearing loss. This study investigated the protective effect of trimetazidine, which has antioxidant and cytoprotective properties, against amikacin ototoxicity.Publication Metadata only Cartilage-Sparing Techniques Versus Percutaneous Adjustable Closed Otoplasty for Prominent Ear Deformity(2014-05-01) Ozturan, ORHAN; Dogan, REMZİ; Eren, SABRİ BAKİ; AKSOY, Fadlullah; VEYSELLER, Bayram; ÖZTURAN, ORHAN; DOĞAN, REMZI; EREN, SABRİ BAKİ; AKSOY, FADLULLAHObjective: The goal of this study is to follow longitudinally the prominent ears treated by either cartilage-sparing techniques (CSTs) or percutaneous adjustable closed otoplasty (PACO) and compare them as to efficacy, reoccurrence, complications, and patient contentedness.Publication Metadata only Betahistine Exacerbates Amikacin Ototoxicity(2015-04-01) AKSOY, Fadlullah; Dogan, REMZİ; Ozturan, ORHAN; Yildirim, YAVUZ SELİM; VEYSELLER, Bayram; Yenigun, ALPER; OZTURK, Burak; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; YILDIRIM, YAVUZ SELİM; YENİGÜN, ALPERObjective: Betahistine augments cochlear blood flow and is currently used as an efficient therapeutic agent. Amikacin is used in a wide range of areas, but its ototoxic effect continues to be problematic. This study investigates the effect of betahistine on amikacin-induced ototoxicity.Publication Metadata only Effect of nasal antihistamine on secretory IgA in nasal lavage of rats(2018-01-01) Dogan, REMZİ; AKSOY, Fadlullah; Goktas, Seda Sezen; Kocak, Ilker; Yildirim, YAVUZ SELİM; Incir, Said; Ozturan, ORHAN; DOĞAN, REMZI; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHANThe humoral IgA is an immunoglobulin which plays a defensive role for organisms on mucosal surfaces. Today, intranasal antihistamines are effectively used in the treatment of allergic rhinitis. In our study, the effect of azelastine hydrochloride-a nasal antihistaminic-on humoral IgA of the nasal mucosa has been reviewed empirically. Twenty-four female Sprague-Dawley rats were included in our study. The rats were divided into three groups randomly. Group 1(azelastine hydrochloride): rats in this group had nasal azelastine hydrochloride (0.05%) applied for 30 days at 10 A mu l/nostril dosage. Group 2 (saline): saline (0.09%) was applied to the rats in this group for 30 days at 10 A mu l/nostril dosage. Group 3 (control): no application was made throughout the study. The chemicals applied in Groups 1 and 2 were applied to both nostrils by mounting a flexible micropipette to the end of an insulin injector. At the beginning of the study, nasal lavage was performed to both nostrils of the rats in every group on the 15th and 30th day to aspirate irrigation solution (distilled water). The aspirated liquids were kept at - 80A degrees temperature and reviewed together at the end of study. Within-group comparisons: in Group 1 (azelastine hydrochloride), the humoral IgA value on the 15th day was significantly higher than the basal value (p = 0.037). There is a significant difference between humoral IgA value on the 30th day and humoral IgA value on the 15th day (p = 0.045). In Group 2 (saline), no significant difference is available between basal, 15th day and 30th day humoral IgA values (p = 0.265). In Group 3 (control), no significant difference is available between basal, 15th day and 30th day humoral IgA values (p = 0.374). Between-group comparison: there is no significant difference in between-group humoral IgA basal values (p = 0.714). On days 15 and 30, Humoral IgA value of Group 1 was significantly higher than that of Groups 2 and 3 (p = 0.013, p = 0.024, respectively). According to the results we achieved in our study, nasal antihistaminic (azelastine hydrochloride) significantly increases the level of humoral IgA. Our study is the first one in the literature to reveal a relation between nasal antihistaminic and humoral IgA and there is a further need for clinical, randomized and prospective studies.Publication Open Access An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats(2015-12-01) TUGRUL, Selahattin; Dogan, REMZİ; AKSOY, Fadlullah; VEYSELLER, Bayrann; Ozer, Omer Faruk; PEKTAS, Alev; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; ÖZER, ÖMER FARUKObjectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.Publication Metadata only Effect of Nasal Corticosteroid on Secretory Immunoglobulin A Measured in Rat Nasal Lavage: Experimental Study(2015-08-01) AKSOY, Fadlullah; Dogan, REMZİ; Kocak, Ilker; VEYSELLER, Bayram; Ozturan, ORHAN; Incir, Said; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHANObjective In this study, we aimed to experimentally investigate the effects of nasal corticosteroids on the levels of secretory immunoglobulin A (sIgA) in nasal mucosa in rats.Publication Metadata only Thermal effects of cold light sources used in otologic surgery(2015-10-01) Dogan, REMZİ; Ozturan, ORHAN; Eren, SABRİ BAKİ; VEYSELLER, Bayram; Gedik, Ozge; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; EREN, SABRİ BAKİ; GEDİK, ÖZGEThe objective of this study was to investigate the thermal effects of cold light sources and endoscopes on the inner ear. 25 male guinea pigs were assigned equally to five groups (1: Halogen-1 min, 2: Halogen-5 min, 3: Xenon-1 min, 4: Xenon-5 min, 5: Controls). After both bullae of the guinea pigs were opened, light sources and endoscopes were positioned in the middle ears of the first four groups for specific time periods. DPOAE and ABR tests were conducted on all animals at the beginning of the study, at the end of surgery, and 2 h after surgery. The temperatures of cold light sources were measured by a thermocouple thermometer, and the surface temperatures of the endoscopes were measured by an infrared thermometer. DPOAE and ABR measurements performed right after and 2 h after surgery in group 1, 2, 3, and 5 did not reveal any significant difference. In group 4, DPOAE values were significantly lower and ABR threshold values were significantly higher than those in the other groups, right after and 2 h after surgery. Thermocouple thermometer readings showed that, after the first minute, the Xenon light source generated significantly more temperature rise than the Halogen light source. The surface temperatures of all endoscopes returned to normal approximately 1 min after light sources were turned off. Our study demonstrated that when an endoscope using a Xenon light source was applied to the middle ear for a specific time periods, inner ear functions deteriorated, as reflected by audiologic tests.