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DOĞAN, REMZI

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REMZI
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DOĞAN
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2015 - 20165
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Author: TUGRUL, Selahattin × Author: SENTURK, EROL ×

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Now showing 1 - 5 of 5
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    Total antioxidant status and oxidative stress in recurrent aphthous stomatitis
    (2016-03-01) TUGRUL, Selahattin; Kocyigit, ABDÜRRAHİM; Dogan, REMZİ; Eren, SABRİ BAKİ; SENTURK, EROL; Ozturan, ORHAN; OZAR, Omer Faruk; KOÇYİĞİT, ABDÜRRAHİM; DOĞAN, REMZI; EREN, SABRİ BAKİ; ŞENTÜRK, EROL; ÖZTURAN, ORHAN; ÖZER, ÖMER FARUK
    BackgroundRecurrent aphthous stomatitis is an idiopathic, chronic, recurrent inflammatory disease of the oral mucosa. It is thought that oxidative stress caused by systemic inflammation plays a basic role in the etiopathogenesis of recurrent aphthous stomatitis. The aim of this study is to review oxidative status and DNA damage in recurrent aphthous stomatitis.
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    Efficacy of nasal corticosteroid in preventing regrowth after adenoidectomy
    (2016-12-01) TUGRUL, Selahattin; Yildirim, YAVUZ SELİM; SENTURK, EROL; Eren, SABRİ BAKİ; Dogan, REMZİ; Ozturan, ORHAN; YILDIRIM, YAVUZ SELİM; ŞENTÜRK, EROL; EREN, SABRİ BAKİ; DOĞAN, REMZI; TUĞRUL, SELAHATTİN; ÖZTURAN, ORHAN
    Objective: One of the most frequent reasons of nasal obstruction and sleep apnea in pediatrics is adenoid hypertrophy. Remaining adenoid tissue can reoccur following hypertrophied adenoid removal and a second operation may be needed. Nasal corticosteroids are utilized in order to reduce adenoid hypertrophy and eliminate adenoidectomy operation. The purpose of our study is to assess the effect of nasal corticosteroid administration after adenoidectomy on adenoid regrowth and symptom scores.
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    A prospective randomized blinded clinical trial: large-volume nasal irrigation with fluticasone propionate in the early postoperative period following septoplasty
    (2015-07-01) TUGRUL, Selahattin; Dogan, REMZİ; SENTURK, EROL; Eren, SABRİ BAKİ; MERIC, Aysenur; Ozturan, ORHAN; DOĞAN, REMZI; ŞENTÜRK, EROL; EREN, SABRİ BAKİ; ÖZTURAN, ORHAN
    BackgroundThe aim of this study was to compare 2 methods of nasal irrigation after septoplasty. The combined use of low-pressure, high-volume nasal saline (LPHVNS) irrigation, together with fluticasone propionate (FP) (LPHVNS+FP), was compared with high-pressure, low-volume nasal saline (HPLVNS) irrigation during the early postoperative period following septoplasty.
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    Effect of the premedication with oral clonidine on surgical comfort in patients undergoing fess due to advanced nasal polyposis: A randomized double blind clinical trial
    (2016-11-01) TUGRUL, Selahattin; Dogan, REMZİ; SENTURK, EROL; Kocak, Ilker; Sezen, SEDA; BAKAN, Mefkur; Ozturan, ORHAN; DOĞAN, REMZI; ŞENTÜRK, EROL; SEZEN GÖKTAŞ, SEDA; ÖZTURAN, ORHAN
    Objective: The objective of this randomized double blind study was to evaluate effect of the premedication with oral clonidine on blood pressure, cleaning of surgical site and bleeding in the ESS performed due to advanced NP.
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    DNA damage and oxidative status in PFAPA syndrome
    (2015-10-01) TUGRUL, Selahattin; Dogan, REMZİ; Kocyigit, ABDÜRRAHİM; Torun, EMEL; SENTURK, EROL; Ozturan, ORHAN; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; KOÇYİĞİT, ABDÜRRAHİM; TORUN, EMEL; ŞENTÜRK, EROL; ÖZTURAN, ORHAN
    Objective: PFAPA syndrome is a clinical entity of unknown etiology which presents with periodic episodes of fever, aphthous stomatitis, tonsillitis or pharyngitis, and cervical adenitis. In this study we investigated DNA damage and the oxidative stress parameters in patients diagnosed with PFAPA, to elucidate the underlying pathophysiological mechanism of this syndrome. Methods: Thirty-one patients diagnosed with PFAPA (Group 1), 22 patients diagnosed with normal tonsillitis or pharyngitis (Group 2), and 20 healthy volunteers (Group 3) were included in our study. Heparinized peripheral blood samples were drawn from all patients and volunteers. DNA damage was assessed by single cell alkaline electrophoresis assay in peripheral mononuclear leukocytes. Plasma levels of total antioxidant status (TAS) and total oxidative status (TOS) were determined by using a novel automated measurement method, and oxidative stress index (OSI) was calculated. Results: DNA damage in the mononuclear leukocytes of Group 1 was significantly higher than that of Group 2 and Group 3. The oxidative stress parameters revealed that the TOS and OSI values of Group 1 were significantly higher than those of Group 2 and Group 3. TAS values of Group 1 were significantly lower than those of Group 2 and Group 3. Correlation analysis of Group 1 demonstrated a significant correlation between TOS, one of the oxidative stress parameters, and DNA damage. Correlations between DNA damage and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values were also significant. Conclusion: Our study indicated that both the inflammatory and the oxidative stress parameters were significantly increased in patients with PFAPA syndrome, accompanied by a significant positive correlation between DNA damage and oxidative stress.