Person: DOĞAN, REMZI
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Publication Metadata only Does systemic steroid deficiency affect inner ear functions?(2015-07-01) Dogan, REMZİ; MERIC, Aysenur; Gedik, Ozge; TUGRUL, Selahattin; Eren, SABRİ BAKİ; Ozturan, ORHAN; DOĞAN, REMZI; MERİÇ HAFIZ, AYŞENUR; GEDİK, ÖZGE; TUĞRUL, SELAHATTİN; EREN, SABRİ BAKİ; ÖZTURAN, ORHANPurpose: Today corticosteroids are employed for the treatment of various inner ear disorders. In this study we have investigated probable changes in hearing functions resulting from a deficiency of systemic steroid secretions.Publication Metadata only Asymmetrically Pressing Nasal Splint for Crooked Nose Deformity(2015-01-01) TUGRUL, Selahattin; Dogan, REMZİ; KOCAK, Ilker; Ozturan, ORHAN; DOĞAN, REMZI; ÖZTURAN, ORHANObjectives: Correcting crooked nose deformity is one of the most difficult procedure in rhinoplastic surgery. For that reason, the authors have been designed an asymmetrically pressing nasal splint. In this prospective study, the aim was to compare the effects of applying asymmetrically pressing nasal splint and normal symmetrically splint on the crooked nose.Publication Metadata only RGB measurements as a novel objective diagnostic test for otitis media with effusion(2015-04-01) TUGRUL, Selahattin; DEGIRMENCI, NAZAN; Eren, SABRİ BAKİ; Dogan, REMZİ; HAFIZ, Aysenur Meric; Ozturan, ORHAN; DEĞİRMENCİ, NAZAN; EREN, SABRİ BAKİ; DOĞAN, REMZI; ÖZTURAN, ORHANConclusions: This study revealed a significant correlation between red-green-blue (RGB) values of tympanic membrane (TM) images and the presence of effusion in the middle ear. These results confirm that endoscopic RGB evaluation is a rapid and non-invasive procedure yielding objective results. Objective: To investigate, in cases of otitis media with effusion (OME), the correlation of the TM color changes with the presence and viscosity of the effusion in the middle ear. Methods: Endoscopic images of the TMs of 52 patients (group 1) and 52 healthy controls (group 2) were taken during their otologic examinations. RGB values of particular points were measured on the TM images of both groups. Additionally, in group 1 the viscosity of each effusion taken by paracentesis during surgery was also measured intraoperatively with a viscometer. Patients with viscosity values lower and higher than 450 cP (centipoise) were subdivided into groups 1a and 1b, respectively. Results: Study and control groups were comparable regarding the number of patients and their mean ages (p > 0.05). Statistically significant differences were found in RGB values of the TM between groups 1 and 2, but not between groups 1a and 1b.Publication Metadata only A prospective randomized blinded clinical trial: large-volume nasal irrigation with fluticasone propionate in the early postoperative period following septoplasty(2015-07-01) TUGRUL, Selahattin; Dogan, REMZİ; SENTURK, EROL; Eren, SABRİ BAKİ; MERIC, Aysenur; Ozturan, ORHAN; DOĞAN, REMZI; ŞENTÜRK, EROL; EREN, SABRİ BAKİ; ÖZTURAN, ORHANBackgroundThe aim of this study was to compare 2 methods of nasal irrigation after septoplasty. The combined use of low-pressure, high-volume nasal saline (LPHVNS) irrigation, together with fluticasone propionate (FP) (LPHVNS+FP), was compared with high-pressure, low-volume nasal saline (HPLVNS) irrigation during the early postoperative period following septoplasty.Publication Open Access DNA damage and oxidative status in PFAPA syndrome(2015-10-01) TUGRUL, Selahattin; Dogan, REMZİ; Kocyigit, ABDÜRRAHİM; Torun, EMEL; SENTURK, EROL; Ozturan, ORHAN; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; KOÇYİĞİT, ABDÜRRAHİM; TORUN, EMEL; ŞENTÜRK, EROL; ÖZTURAN, ORHANObjective: PFAPA syndrome is a clinical entity of unknown etiology which presents with periodic episodes of fever, aphthous stomatitis, tonsillitis or pharyngitis, and cervical adenitis. In this study we investigated DNA damage and the oxidative stress parameters in patients diagnosed with PFAPA, to elucidate the underlying pathophysiological mechanism of this syndrome. Methods: Thirty-one patients diagnosed with PFAPA (Group 1), 22 patients diagnosed with normal tonsillitis or pharyngitis (Group 2), and 20 healthy volunteers (Group 3) were included in our study. Heparinized peripheral blood samples were drawn from all patients and volunteers. DNA damage was assessed by single cell alkaline electrophoresis assay in peripheral mononuclear leukocytes. Plasma levels of total antioxidant status (TAS) and total oxidative status (TOS) were determined by using a novel automated measurement method, and oxidative stress index (OSI) was calculated. Results: DNA damage in the mononuclear leukocytes of Group 1 was significantly higher than that of Group 2 and Group 3. The oxidative stress parameters revealed that the TOS and OSI values of Group 1 were significantly higher than those of Group 2 and Group 3. TAS values of Group 1 were significantly lower than those of Group 2 and Group 3. Correlation analysis of Group 1 demonstrated a significant correlation between TOS, one of the oxidative stress parameters, and DNA damage. Correlations between DNA damage and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values were also significant. Conclusion: Our study indicated that both the inflammatory and the oxidative stress parameters were significantly increased in patients with PFAPA syndrome, accompanied by a significant positive correlation between DNA damage and oxidative stress.Publication Open Access An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats(2015-12-01) TUGRUL, Selahattin; Dogan, REMZİ; AKSOY, Fadlullah; VEYSELLER, Bayrann; Ozer, Omer Faruk; PEKTAS, Alev; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; ÖZER, ÖMER FARUKObjectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.Publication Metadata only Split Cartilage Resection of Nasal Dome: A Solution to Ptotic Nasal Tips(2015-07-01) TUGRUL, Selahattin; Dogan, REMZİ; Kocak, Ilker; Eren, SABRİ BAKİ; Ozturan, ORHAN; DOĞAN, REMZI; EREN, SABRİ BAKİ; ÖZTURAN, ORHANObjective: In ptotic noses, it is rather difficult to achieve the intended functional and cosmetic result without modifying the alar cartilage and creating a new nasal tip. The split cartilage resection method was intended to create a new and permanent nasal tip to protect the physiologic and cosmetic appearance of the nose in the presence of long and ptotic nasal tip.