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DOĞAN, REMZI

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REMZI
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DOĞAN
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Author: Dogan, REMZİ × Author: KOÇYİĞİT, ABDÜRRAHİM × Author: TUGRUL, Selahattin ×

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    Total antioxidant status and oxidative stress in recurrent aphthous stomatitis
    (2016-03-01) TUGRUL, Selahattin; Kocyigit, ABDÜRRAHİM; Dogan, REMZİ; Eren, SABRİ BAKİ; SENTURK, EROL; Ozturan, ORHAN; OZAR, Omer Faruk; KOÇYİĞİT, ABDÜRRAHİM; DOĞAN, REMZI; EREN, SABRİ BAKİ; ŞENTÜRK, EROL; ÖZTURAN, ORHAN; ÖZER, ÖMER FARUK
    BackgroundRecurrent aphthous stomatitis is an idiopathic, chronic, recurrent inflammatory disease of the oral mucosa. It is thought that oxidative stress caused by systemic inflammation plays a basic role in the etiopathogenesis of recurrent aphthous stomatitis. The aim of this study is to review oxidative status and DNA damage in recurrent aphthous stomatitis.
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    Can Oxidative Stress Parameters Be Used as Biomarkers for the Discrimination of Malignant Head and Neck Tumors
    (2016-05-01) Dogan, REMZİ; HAFIZ, Aysenur Meric; TUGRUL, Selahattin; Ozturan, ORHAN; KESKIN, Siddika; Kocyigit, ABDÜRRAHİM; DOĞAN, REMZI; TUĞRUL, SELAHATTİN; ÖZTURAN, ORHAN; KOÇYİĞİT, ABDÜRRAHİM
    Objective: In this study the authors have investigated oxidative stress parameters in sera and tissues, and evaluated their significance for the differentiation of malignant and benign tumors.
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    DNA damage and oxidative status in PFAPA syndrome
    (2015-10-01) TUGRUL, Selahattin; Dogan, REMZİ; Kocyigit, ABDÜRRAHİM; Torun, EMEL; SENTURK, EROL; Ozturan, ORHAN; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; KOÇYİĞİT, ABDÜRRAHİM; TORUN, EMEL; ŞENTÜRK, EROL; ÖZTURAN, ORHAN
    Objective: PFAPA syndrome is a clinical entity of unknown etiology which presents with periodic episodes of fever, aphthous stomatitis, tonsillitis or pharyngitis, and cervical adenitis. In this study we investigated DNA damage and the oxidative stress parameters in patients diagnosed with PFAPA, to elucidate the underlying pathophysiological mechanism of this syndrome. Methods: Thirty-one patients diagnosed with PFAPA (Group 1), 22 patients diagnosed with normal tonsillitis or pharyngitis (Group 2), and 20 healthy volunteers (Group 3) were included in our study. Heparinized peripheral blood samples were drawn from all patients and volunteers. DNA damage was assessed by single cell alkaline electrophoresis assay in peripheral mononuclear leukocytes. Plasma levels of total antioxidant status (TAS) and total oxidative status (TOS) were determined by using a novel automated measurement method, and oxidative stress index (OSI) was calculated. Results: DNA damage in the mononuclear leukocytes of Group 1 was significantly higher than that of Group 2 and Group 3. The oxidative stress parameters revealed that the TOS and OSI values of Group 1 were significantly higher than those of Group 2 and Group 3. TAS values of Group 1 were significantly lower than those of Group 2 and Group 3. Correlation analysis of Group 1 demonstrated a significant correlation between TOS, one of the oxidative stress parameters, and DNA damage. Correlations between DNA damage and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values were also significant. Conclusion: Our study indicated that both the inflammatory and the oxidative stress parameters were significantly increased in patients with PFAPA syndrome, accompanied by a significant positive correlation between DNA damage and oxidative stress.