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DOĞAN, REMZI

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REMZI
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DOĞAN
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2014 - 20152
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Author: AKSOY, FADLULLAH × Type: Article × Rights: info:eu-repo/semantics/openAccess ×

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    PublicationOpen Access
    Investigation of the role of major respiratory viruses in the aetiology of nasal polyps using polymerase chain reaction technique
    (2014-04-01) YENIGUN, A.; AKSOY, FEYZA MÜBERRA; DOGAN, REMZİ; Yilmaz, F.; Ozturan, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN; YENİGÜN, VILDAN BETÜL
    Objective: We aimed to identify the role of major respiratory viruses in the aetiology of human nasal polyps using polymerase chain reaction technique. Methods: Thirty patients with nasal polyps and a group of 20 healthy patients (control group) were included in this study. Mucosa was obtained from the polyps of patients with nasal polyposis and from the middle turbinate of the control group patients by means of biopsy. The samples were stored at -80 °C until molecular analysis by polymerase chain reaction was carried out. Results: In the control group, the human coronavirus and human rhinovirus were diagnosed in one of the patients and the human respiratory syncytial virus in another. In the group with nasal polyposis, the influenza B virus was identified in one of the patients and the human coronavirus in another. Conclusion: The results did not demonstrate a statistically significant relationship between nasal polyposis and respiratory viruses.
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    PublicationOpen Access
    An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats
    (2015-12-01) TUGRUL, Selahattin; Dogan, REMZİ; AKSOY, Fadlullah; VEYSELLER, Bayrann; Ozer, Omer Faruk; PEKTAS, Alev; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; ÖZER, ÖMER FARUK
    Objectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.