Person: ALİM TORAMAN, GÜLBAHAR ÖZGE
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Publication Open Access Isoquinoline alkaloids isolated from Glaucium corniculatum var. corniculatum and Glaucium grandiflorum subsp. refractum var. torquatum with bioactivity studies(2023-06-01) Kuşman Sayğı T.; Tan N.; Alim Toraman G. Ö.; Gürer Ç.; Tugay O.; Topçu G.; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIContext: The genus Glaucium Mill., one of the important Papaveraceae family plants, is rich in isoquinoline alkaloids and distributed worldwide. Objective: Isolation and identification of bioactive alkaloids from Glaucium grandiflorum Boiss. & Huet. subsp. refractum (Nabelek) Mory var. torquatum (Cullen) Mory and G. corniculatum (L.) Rudolph var. corniculatum (Aslan 2012), and investigation of their antioxidant and anticholinesterase activities. Materials and methods: The aerial parts of each plant were dried, powdered, and percolated with methanol, then each extract was fractionated between 50% aqueous acetic acid and petroleum. Their aqueous acidic layer was adjusted to pH 7-8 with NH4OH and extracted with chloroform, the extract was subjected to CC separation and isolation. Structures of the isolated alkaloids were elucidated by 1D and 2D-NMR and mass spectral analyses. The alkaloid extracts and their pure alkaloids were tested for anti-cholinesterase (AChE and BuChE) and antioxidant (ABTS, CUPRAC, β-carotene linoleic acid tests) activities in vitro. Results: Methanol extracts of Glaucium grandiflorum subsp. refractum var. torquatum and G. corniculatum var. corniculatum afforded a novel compound glauciumoline and seven known isoquinoline alkaloids three of which have an aporphine-type and the other five have a protopine-type skeleton. Among them, trans-protopinium (7) and cis-protopinium (8) were isolated from a Glaucium species for the first time. Tertiary amine extracts (TAEs) of both plants showed very strong acetylcholinesterase inhibitory activity. The TAE of the plants also showed strong antioxidant activity while the isolated alkaloids showed no meaningful activity in the anticholinesterase and antioxidant tests. Discussion and conclusions: Glaucium species are considered promising therapeutic agents in the treatment of Alzheimer's disease.Publication Metadata only Novel Chalcone Derivatives of Ursolic Acid as Acetylcholinesterase Inhibitors: Synthesis, Characterization, Biological Activity, ADME prediction, Molecular Docking and Molecular Dynamics Studies(2023-10-01) Şenol H.; Ghaffari-Moghaddam M.; Alim Toraman G. Ö.; Güller U.; ŞENOL, HALIL; ALİM TORAMAN, GÜLBAHAR ÖZGEPublication Metadata only Cytotoxic meroterpenoids from brown alga Stypopodium schimperi (Kützing) Verlaque & Boudouresque with comprehensive molecular docking & dynamics and ADME studies(2024-01-01) Demirkıran Ö.; Erol E.; Şenol H.; Kesdi İ. M.; Alim Toraman G. Ö.; Okudan E. Ş.; Topçu G.; EROL, EBRU; ŞENOL, HALIL; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIPublication Metadata only Onosma ambigens Lacaita: Evaluation of Cholinesterase Inhibitory Activity(2024-04-05) Göç F.; Alim Toraman G. Ö.; Yanıkoğlu R. S.; Demirel F.; Uluocak B.; Pakkan H.; Başoğlu K.; Selvi B.; Topçu G.; GÖÇ, FATMA; ALİM TORAMAN, GÜLBAHAR ÖZGE; YANIKOĞLU, RABİA SARE; TOPÇU, GÜLAÇTIPublication Metadata only The Caenorhabditis elegans Life-Span Activity of Trigonella foenum-graecum Seed Extracts(2023-10-08) Yanartaş A.; Güleç M.; Yanıkoğlu R. S.; Göç F.; Alim Toraman G. Ö.; Topçu G.; YANIKOĞLU, RABİA SARE; GÖÇ, FATMA; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIPublication Metadata only Di-, and Triterpenoids Isolation of Endemic Two Varieties of Salvia sericeotomentosa with Anticholinesterase Inhibitory Activity(2024-05-12) Alim Toraman G. Ö.; Tan N.; Topçu G.; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIPublication Metadata only Polar Extracts Preparation of Platanus orientalis and Determination of Their Phytochemical Content by LC-HRMS Analysis(2024-05-12) Demirel F.; Alim Toraman G. Ö.; Sağıroğlu A. A.; Tan N.; Günaydın Akyıldız A.; Topçu G.; ALİM TORAMAN, GÜLBAHAR ÖZGE; GÜNAYDIN AKYILDIZ, AYŞENUR; TOPÇU, GÜLAÇTIPublication Metadata only INVESTIGATION OF ANTIMICROBIAL PROPERTIES AND CHEMICAL COMPOSITIONS OF POLAR EXTRACTS FROM SELECTED SALVIA SPECIES(2024-05-12) Yazıcı Tütüniş S.; Alim Toraman G. Ö.; Akalın E.; Tan E.; Gören A. C.; Miski M.; Topçu G.; Tan N.; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIPublication Metadata only LC-HRMS ANALYSES OF SALVIA VENERIS HEDGE ROOT EXTRACTS WITH ANTI-ALZHEIMER ACTIVITY(2024-05-12) Alim Toraman G. Ö.; Tan N.; Gülsoy Toplan G.; Sarıyar G.; Yıldız Peköz A.; Gürer Ç.; ALİM TORAMAN, GÜLBAHAR ÖZGE