Person:
ONSUN, NAHIDE

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Kurumdan Ayrılmıştır.

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Organizational Unit

Tıp Fakültesi

First Name

NAHIDE

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ONSUN

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Now showing 1 - 10 of 32

Open Access
Poxvirus-induced angiogenesis after a thermal burn
(2014-09-01) Biyik Ozkaya, DİLEK; TASKIN, Banu; TAS, Betul; ASIRAN SERDAR, Zehra; Demirkesen, Cuyan; Su, Ozlem; Onsun, NAHİDE; BIYIK ÖZKAYA, DİLEK; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Orf (contagious ecthyma) is a zoonotic infection caused by a dermatotropic parapoxvirus that commonly infects sheep, goats, and oxen. Parapoxviruses are transmitted to humans through contact with an infected animal or fomites. Orf virus infections can induce ulceration, and papulonodular, pustular, or ecthymic lesions of the skin after contact with an infected animal or contaminated fomite. Rarely, orf virus provokes extensive vasculo-endothelial proliferation as a skin manifestation. Here, we present the case of an 8-year old female with poxvirus-induced vascular angiogenesis that developed 10days after a thermal burn. An 8-year-old female presented at our outpatient clinic with red swellings and a yellow-brown crust on them. After a thermal burn with hot water, she went to a clinic and the burn was dressed with nitrofurazone and covered for 2days. When the dressing was removed after 2days, nodules were seen in the burnt areas. When the clinical findings were considered with the histopathological features, a reactive vascular proliferation due to a viral agent was suspected. Following PCR, parapoxvirus ovis was detected. Viral infections such as pox virus can trigger pyogenic granulomas or pyogenic granuloma-like vascular angiogenesis. Infectious agents must be considered when dealing with pyogenic granuloma-like lesions.
Open Access
Ambulatory Blood Pressure Monitoring Could Unmask Hypertension in Patients with Psoriasis Vulgaris
(2013-10-29) BACAKSIZ, AHMET; Erdogan, Ercan; Sonmez, Osman; Sevgili, Emrah; Tasal, Abdurrahman; ONSUN, NAHİDE; Topukcu, Bugce; Kulac, Beytullah; UYSAL, ÖMER; Goktekin, Omer; BACAKSIZ, AHMET; ONSUN, NAHIDE; UYSAL, ÖMER
Background: Psoriasis vulgaris is one of the most prevalent chronic, inflammatory skin disorders. Patients with psoriasis have excess risk of essential hypertension. Masked hypertension (MH), defined as normal office blood pressure (BP) with elevated ambulatory BP (ABPM), has been drawing attention recently due to its association with increased risk of developing sustained hypertension, cardiovascular morbidity, and mortality. The aim of this study was to investigate the prevalence of MH in psoriatic patients. Material and Methods: On hundred and ten middle-aged, normotensive, non-obese patients with psoriasis vulgaris and 110 age- and sex-matched normotensive controls were included in the study. ABPM was performed in all participants over a 24-h period. The clinical severity of the disease was determined according to current indexes. Results: The prevalence of MH among subjects with psoriasis vulgaris was 31.8% and increased compared to control subjects (p<0.01). Predictors of MH in patients with psoriasis vulgaris were detected as male sex, smoking, obesity-related anthropometric measures, and disease activity. Male sex, waist circumference, and diffuse psoriatic involvement were detected as independent predictors of MH. Conclusions: MH is prevalent in patients with psoriasis vulgaris. Assessment with ABPM and close follow-up for development of hypertension is reasonable.
Open Access
The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population
(2019-01-01T00:00:00Z) ONSUN, NAHİDE; Pirmit, Serpil; Ozkaya, Dilek; Çelik, Şirin; Rezvani, Aylin; CENGİZ, Fatma Pelin; Kekik, Cigdem; ONSUN, NAHIDE; REZVANİ, AYLİN; CENGİZ, FATMA PELIN
Background. Psoriasis is a multifactorial immune-mediated infammatory disease triggered by both genetic and environmental factors. Te strong association between psoriasis and HLA-C∗06 allele has been demonstrated in various races. Te HLAC∗12 allele is closely related to the HLA-C∗06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C∗12 and psoriasis in the Turkish population. Te present study aims to determine this relationship. Methods. Tis case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C∗06, HLA-C∗12, and HLA-C∗04 alleles were most commonly observed in psoriasis patients. HLA-C∗06 and HLA-C∗12 were signifcantly more frequent in the psoriasis group. HLA-C∗06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C∗12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C∗12 allele. Conclusions. HLA-C∗12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.
Open Access
Demographic characteristics, aetiology, and assessment of treatment options in leukocytoclastic vasculitis.
(2017-04-01) CAKıTER, AU; Kucuk, OS; OZKAYA, DB; TOPUKÇU, B; ONSUN, NAHİDE; SU KÜÇÜK, ÖZLEM; BIYIK ÖZKAYA, DİLEK; ONSUN, NAHIDE
Introduction: Vasculitides are a heterogeneous group of diseases characterized by inflammation of the blood vessel walls. Etiological factors include infections, drugs, connective tissue diseases, and malignancies. Aim: To examine the demographic characteristics, etiological factors, and treatment options in 75 patients with leukocytoclastic vasculitis. Material and methods: The study included 75 patients diagnosed with leukocytoclastic vasculitis at our clinic. The patients’ medical records were reviewed to determine their age, sex, presence of systemic symptoms, possible etiological factors, laboratory results, types of cutaneous lesions, locations of the lesions, treatment options, and disease course. Results: There were 43 women and 32 men. Cutaneous lesions affected only the lower limbs in 60 of the 75 patients (80%) and usually presented as palpable purpura (64%, n = 48). Arthralgia (26.7%, n = 20) was the most frequent extracutaneous symptom. Of the patients with secondary vasculitis, the most common causes were infections and drugs. The mean age of the patients with Henoch-Schönlein purpura was 26.8 years. There was no significant association between age and renal, gastrointestinal, or joint involvement. Conclusions: The most common form of vasculitis in our study was cutaneous leukocytoclastic vasculitis. In most of the patients it appeared to be idiopathic. Among drugs, antibiotics were the most common etiological factor. In 4 patients, the cutaneous leukocytoclastic vasculitis behaved like the paraneoplastic syndrome.
Open Access
Comparison of Efficiency and Adverse Effects of Etanercept, Infliximab and Adalimumab in Patients with Psoriasis Vulgaris
(2012-03-01) SEN, Ayse Pekdemir; Onsun, NAHİDE; Su, Ozlem; CINKAYA, Ayse; ONSUN, NAHIDE; SU KÜÇÜK, ÖZLEM
Background and Design: Our aim was to evaluate and compare the effects, side effects, and onset and duration of action of etanercept, infliximab and adalimumab on patients followed in our psoriasis outpatient clinic.
Open Access
The relationship between pruritus and clinical variables in patients with psoriasis
(2017-07-01) Su, Ozlem; Bahali, ANIL GÜLSEL; Onsun, NAHİDE; OZKAYA, Dilek Biyik; Dizman, DİDEM; TOPUKCU, Bugce; Uysal, Omer; BAHALI, ANIL GÜLSEL; ONSUN, NAHIDE; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEM; UYSAL, ÖMER
Pruritus is the most commonly occurring subjective symptom of dermatological disease. Published data on both prevalence and intensity of pruritus in psoriasis is limited. Objective: In this study we aimed to investigate the prevalence of pruritus and its relation with psoriasis area severity index, body mass index and presence of systemic disease in patients with psoriasis. Methods: We analyzed data of psoriatic patients diagnosed in our psoriasis outpatient clinic between March 2013 and June 2014 collected retrospectively from PSR-TR registration system. Results: In total, 880 patients were analyzed. Pruritus was more prominent in female patients. This difference was statistically significant. No significant associations were found between age of patients, clinical type of disease and pruritus. The itching was more common in patients with higher body mass index. Presence of pruritus was correlated significantly with severity of psoriasis. Five hundred and sixty of 880 patients had no systemic disease. The presence of pruritus was not related with presence of systemic disease. Existence of systemic disease with psoriasis has minimal effect on pruritus. Study Limitations: We did not evaluate intensity of pruritus. Conclusions: Pruritus is not mentioned within the classical symptoms of psoriasis. Pruritus in psoriasis is a very unpleasant symptom with great potential to impair patient’s quality of life and may exacerbate psoriasis as a Koebner phenomenon. Keywords: Patients; Psoriasis; Pruritus
Open Access
Dermoscopic Features of Small, Medium, and Large-Sized Congenital Melanocytic Nevi
(2017-02-01) Cengiz, FATMA PELİN; Emiroglu, NAZAN; OZKAYA, Dilek Biyik; Onsun, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Background: Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma. Objective: To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. Methods: A nonrandomized observational study was performed. A total of 108 melanocytic nevi were analysed by clinical and dermoscopic examination. Results: Of the subjects, 57.4% were aged less than 16 years, 42.6% were aged 16 and more. Of the nevi, 26 had reticular pattern (24.1%), 35 had globular pattern (32.4%), 13 had reticular-globular pattern (12.0%), 16 had homogeneous pattern (14.8%), 6 had reticular-homogeneous pattern (5.6%), 2 had globular-homogeneous pattern (1.9%), 7 had cobblestone pattern (6.5%), 3 had reticular patchy pattern (2.8%). Atypical dots and globules, focal hypopigmentation and perifollicular hypopigmentation are the most common dermoscopic features of CMN. The rarest dermoscopic feature is the blue-whitish veil. Conclusion: Most of the dermoscopic features related with dysplastic nevi up to the present, such as atypical dots and globules, focal hypopigmentation, perifollicular hypopigmentation were observed in CMN, in our study. Congenital nevus and dysplastic nevi may share the same dermoscopic features, therefore it is important to know it is found at birth or not.
Open Access
Frequency and risk factors for secondary malignancies in patients with mycosis fungoides
(2016-08-01) EMIROGLU, NAZAN; CENGIZ, F. P.; BAHALI, A. Gulsel; Su, O.; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), has an incidence of 6.4 per million people [1]. Patients with CTCL have an increased risk of the development of secondary malignancies, particularly lymphomas [2,3]. We conducted a 20-year population-based cohort study to assess the risk factors of secondary cancers in MF patients from our center.
Open Access
The allergens causing contact sensitization in textile industry workers
(2014-09-01) Su, Ozlem; OZKAYA, Dilek Biyik; PIRMIT, Serpil; ULUSAL, Hande Arda; Onsun, NAHİDE; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Background and Design: Our aim was to determine the frequency of contact sensitization to textile materials and the most common textile allergens in patients who work in the textile industry and have been diagnosed with allergic contact dermatitis (ACD). Materials and Methods: Fifty textile industry workers, who attended our outpatient clinic with the diagnosis of ACD, between October 2005-December 2009, were enrolled in this study. While 50 patients were tested with the Thin layer-Rapid-Use-Epicutaneous (TRUE) test, 36 patients were tested with the TRUE test and textile series allergen. The results were analyzed as percentage and statistically. Results: Of the 50 patients, 34 (68%) were men, 16 (32%) were women. The mean of the subjects was 37.4 years. In 38.8 of the patients in whom TRUE test and textile series allergens applied together, at least one allergic reaction was seen. Of the 36 patients applied textile series in addition to the TRUE test, 33.3% of patients had positive reaction to only textile allergens, 2.7% to only standard series allergens, and 2.7% of subjects had positive reaction to both textile series and standard series allergens. 76.9% of these reactions were to dyes, 15.3% to resins and 7.6% of them were to both of them. Disperse blue 106(8.3%), acid red 359 (8.3%) and disperse red 17(5.5%) were the most positive reaction seen dyes. 18% of 50 patients tested with TRUE test alone showed at least one positive reaction. The most common standard series allergens were nickel sulphate (6%) and ethylenediamine dihydrocloride (6%). Both the relationship between atopy and contact sensitization and also the relationship with hand localization and contact sensitization to textile allergens were not statistically significant. Conclusion: In occupational textile dermatitis, contact sensitization is common and especially seen to disperse dyes. For the contact sensitization to textile materials, standard series allergens cannot be adequate in finding causative agent.
Open Access
Dermatoscopic findings of pigmented purpuric dermatosis
(2016-09-01) Su, Ozlem; OZKAYA, Dilek Biyik; Emiroglu, NAZAN; Cengiz, FATMA PELİN; Bahali, ANIL GÜLSEL; Yildiz, PELİN; DEMIRKESEN, Cuyan; Onsun, NAHİDE; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; CENGİZ, FATMA PELIN; BAHALI, ANIL GÜLSEL; YILDIZ, PELİN; ONSUN, NAHIDE
ackground:: Pigmented purpuric dermatosis is a chronic skin disorder of unknown aetiology characterised by symmetrical petechial and pigmented macules, often confined to the lower limbs. The aetiology of pigmented purpuric dermatosis is unknown. Dermatoscopy is a non-invasive diagnostic technique that allows the visualisation of morphological features invisible to the naked eye; it combines a method that renders the corneal layer of the skin translucent with an optical system that magnifies the image projected onto the retina. Objectives:: The aim of this study is to investigate the dermatoscopic findings of pigmented purpuric dermatosis. Methods:: This study enrolled patients diagnosed histopathologically with pigmented purpuric dermatosis who had dermatoscopic records. We reviewed the dermatoscopic images of PPD patients who attended the outpatient clinic in the Istanbul Dermatovenereology Department at the Bezmialem Vakıf University Medical Faculty. Results:: Dermatoscopy showed: coppery-red pigmentation (97%, n = 31) in the background, a brown network (34%, n = 11), linear vessels (22%, n = 7), round to oval red dots, globules, and patches (69%, n = 22; 75%, n = 24; 34%, n = 11; respectively), brown globules (26%, n = 8) and dots (53%, n = 17), linear brown lines (22%, n = 7), and follicular openings (13%, n = 4). Conclusion:: To our knowledge, this is the first study to report the dermatoscopy of pigmented purpuric dermatosis. In our opinion, dermatoscopy can be useful in the diagnosis of pigmented purpuric dermatosis.