Person: ONSUN, NAHIDE
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Publication Open Access Poxvirus-induced angiogenesis after a thermal burn(2014-09-01) Biyik Ozkaya, DİLEK; TASKIN, Banu; TAS, Betul; ASIRAN SERDAR, Zehra; Demirkesen, Cuyan; Su, Ozlem; Onsun, NAHİDE; BIYIK ÖZKAYA, DİLEK; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEOrf (contagious ecthyma) is a zoonotic infection caused by a dermatotropic parapoxvirus that commonly infects sheep, goats, and oxen. Parapoxviruses are transmitted to humans through contact with an infected animal or fomites. Orf virus infections can induce ulceration, and papulonodular, pustular, or ecthymic lesions of the skin after contact with an infected animal or contaminated fomite. Rarely, orf virus provokes extensive vasculo-endothelial proliferation as a skin manifestation. Here, we present the case of an 8-year old female with poxvirus-induced vascular angiogenesis that developed 10days after a thermal burn. An 8-year-old female presented at our outpatient clinic with red swellings and a yellow-brown crust on them. After a thermal burn with hot water, she went to a clinic and the burn was dressed with nitrofurazone and covered for 2days. When the dressing was removed after 2days, nodules were seen in the burnt areas. When the clinical findings were considered with the histopathological features, a reactive vascular proliferation due to a viral agent was suspected. Following PCR, parapoxvirus ovis was detected. Viral infections such as pox virus can trigger pyogenic granulomas or pyogenic granuloma-like vascular angiogenesis. Infectious agents must be considered when dealing with pyogenic granuloma-like lesions.Publication Metadata only Unilateral linear punctate palmar keratoderma(2014-05-01) Biyik Ozkaya, DİLEK; TAS, Betul; Su, Ozlem; UNAL CAKITER, Alkim; Tosuner, ZEYNEP; Demirkesen, Cuyan; Onsun, NAHİDE; BIYIK ÖZKAYA, DİLEK; SU KÜÇÜK, ÖZLEM; TOSUNER, ZEYNEP; ONSUN, NAHIDEPublication Open Access The allergens causing contact sensitization in textile industry workers(2014-09-01) Su, Ozlem; OZKAYA, Dilek Biyik; PIRMIT, Serpil; ULUSAL, Hande Arda; Onsun, NAHİDE; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEBackground and Design: Our aim was to determine the frequency of contact sensitization to textile materials and the most common textile allergens in patients who work in the textile industry and have been diagnosed with allergic contact dermatitis (ACD). Materials and Methods: Fifty textile industry workers, who attended our outpatient clinic with the diagnosis of ACD, between October 2005-December 2009, were enrolled in this study. While 50 patients were tested with the Thin layer-Rapid-Use-Epicutaneous (TRUE) test, 36 patients were tested with the TRUE test and textile series allergen. The results were analyzed as percentage and statistically. Results: Of the 50 patients, 34 (68%) were men, 16 (32%) were women. The mean of the subjects was 37.4 years. In 38.8 of the patients in whom TRUE test and textile series allergens applied together, at least one allergic reaction was seen. Of the 36 patients applied textile series in addition to the TRUE test, 33.3% of patients had positive reaction to only textile allergens, 2.7% to only standard series allergens, and 2.7% of subjects had positive reaction to both textile series and standard series allergens. 76.9% of these reactions were to dyes, 15.3% to resins and 7.6% of them were to both of them. Disperse blue 106(8.3%), acid red 359 (8.3%) and disperse red 17(5.5%) were the most positive reaction seen dyes. 18% of 50 patients tested with TRUE test alone showed at least one positive reaction. The most common standard series allergens were nickel sulphate (6%) and ethylenediamine dihydrocloride (6%). Both the relationship between atopy and contact sensitization and also the relationship with hand localization and contact sensitization to textile allergens were not statistically significant. Conclusion: In occupational textile dermatitis, contact sensitization is common and especially seen to disperse dyes. For the contact sensitization to textile materials, standard series allergens cannot be adequate in finding causative agent.Publication Metadata only HIRSUTISM IN WOMEN OF REPRODUCTIVE AGE: ETIOLOGICAL FACTORS, CLINICAL SIGNS, AND HORMONAL PROFILE(2014-09-01T00:00:00Z) Cebeci, Filiz; ONSUN, Nahide; Sen, Ayse Pekdemir; Cinkaya, Ayse; Akar, Sermet; ONSUN, NAHIDEObjective: Hirsutism is a common endocrinological clinical problem seen in women at reproductive age. Although its cause is usually a benign condition, it may rarely be an indication of a more serious endocrine disease, such as Cushing syndrome or an androgen-secreting tumor The objective of this study was to investigate the clinical features of hirsutism and its etiologic factors in women with hirsutism at reproductive age.Publication Open Access Body mass index and psoriasis area and severity index relation in Turkish psoriasis population(2014-09-01) OZKAYA, Dilek Biyik; Onsun, NAHİDE; TOPUKCU, Bugce; Su, Ozlem; Dizman, DİDEM; Uysal, Omer; ONSUN, NAHIDE; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEM; UYSAL, ÖMERBackground and Design: Psoriasis is a chronic immune-mediated inflammatory disease affecting 1-3% of the general population. Recently, it has been suggested that chronic inflammation in psoriasis may cause metabolic and vascular disorders. Most of recent studies focused on the comorbidities and the mechanisms of comorbidities associated with psoriasis. Obesity may lead to cardiovascular disorders, diyabetes mellitus, hypertension, malignancies, musculoskeleteal system diseases, impaired quality of life, and death. In this study, we aimed to investigate the prevalence of obesity in patients with psoriasis and the relationship between the disease severity and body mass index (BMI) in Turkish psoriasis population.Publication Metadata only Pitfalls of an Automated Dermoscopic Analysis System in the Differential Diagnosis of Melanocytic Lesions(2014-01-01) OZKAYA, Dilek Biyik; Onsun, NAHİDE; ULUSAL, Hande Arda; PIRMIT, Serpil; BIYIK ÖZKAYA, DİLEK; ONSUN, NAHIDE; SU KÜÇÜK, ÖZLEMDermoscopy plays an important role in the diagnosis of pigmented lesions, particularly in the differential diagnosis of early-stage melanoma. Dermoscopy systems that aim to enable automatic -unmanned-without physician- diagnosis are becoming increasingly common. We aimed to investigate the reliability and weaknesses of diagnosis programs. Furthermore, we attempted to determine whether such programs are superior to diagnosis by a physician, compared to histopathological assessment. The images stored in the DermoGenius ultra-computerized dermoscopy system of the Dermoscopy Unit between January 2008 and December 2008 were surveyed retrospectively. Dermoscopic images made prior to excision of 77 lesions from 51 patients verified by histopathology were reviewed. Nineteen patients were men and 32 were women. Mean age was 35.5 years. Diagnosis by a clinician or automatic analysis revealed that 23 (30%) of the lesions were atypical (dysplastic) nevi, 22 (29%) were compound nevi, 10 (13%) were dermal nevi, 8 (10%) were malignant melanomas, 7 (9%) were common nevi, 6 (7%) were junctional nevi, and 1 (1%) was a blue nevus. Compared to histopathological diagnosis, considered the gold standard, the sensitivity of the automated analysis program was 96.6%, its specificity 14.9%, and its diagnostic accuracy 47%. For the clinician, the values were 100% for sensitivity, 66.7% for specificity, and 95% for diagnostic accuracy.Publication Metadata only The relationship between deep vein thrombosis and erythema nodosum in male patients with Behcet-s disease(2014-11-01T00:00:00Z) Cebeci, F.; ONSUN, Nahide; Ulusal, H. A.; Inan, B.; ONSUN, NAHIDEOBJECTIVE: The pathogenesis of thrombosis in Behcet-s Disease (BD) is unknown, however, multiple factors leading to the disease may include hypercoagulability, hypofibrinolysis and endothelial injury. We sought to evaluate the frequency of erythema nodosumlike lesions (ENLL) due to the presence of vasculitis in ENLL observed in BD in male patients with BD with and without deep vein thrombosis. To our knowledge this is the first study to investigate the association of ENLL between the groups with or without thrombosis in only male patients with BD.