(2010-09-01T00:00:00Z) ULUSAL, Hande Arda; Su, Ozlem; CEBECI, Filiz; SAKIZ, Damlanur; Onsun, NAHİDE; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
The concomitant occurrence of psoriasis and bullous pemphigoid has been described previously, but the pathogenic mechanism of this relationship is still unknown. We describe a 34-year-old woman with a 22-year history of plaque-type psoriasis. On the third day of hospitalization, disseminated tense bullae developed on her neck and upper extremities. Histologic examination of biopsy specimen obtained from a vesicular lesion demonstrated a subepidermal blister. Direct immunofluorescence revealed IgG and C3 deposition in a linear pattern at the basement membrane zone. Both diseases were successfully treated with cyclosporine. However, the coexistence of these conditions represents a difficult therapeutic challenge. (Turkderm 2010; 44: 167-9)
