Person:
ONSUN, NAHIDE

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Kurumdan Ayrılmıştır.

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Organizational Unit

Tıp Fakültesi

First Name

NAHIDE

Last Name

ONSUN

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Now showing 1 - 10 of 10

Open Access
Ambulatory Blood Pressure Monitoring Could Unmask Hypertension in Patients with Psoriasis Vulgaris
(2013-10-29) BACAKSIZ, AHMET; Erdogan, Ercan; Sonmez, Osman; Sevgili, Emrah; Tasal, Abdurrahman; ONSUN, NAHİDE; Topukcu, Bugce; Kulac, Beytullah; UYSAL, ÖMER; Goktekin, Omer; BACAKSIZ, AHMET; ONSUN, NAHIDE; UYSAL, ÖMER
Background: Psoriasis vulgaris is one of the most prevalent chronic, inflammatory skin disorders. Patients with psoriasis have excess risk of essential hypertension. Masked hypertension (MH), defined as normal office blood pressure (BP) with elevated ambulatory BP (ABPM), has been drawing attention recently due to its association with increased risk of developing sustained hypertension, cardiovascular morbidity, and mortality. The aim of this study was to investigate the prevalence of MH in psoriatic patients. Material and Methods: On hundred and ten middle-aged, normotensive, non-obese patients with psoriasis vulgaris and 110 age- and sex-matched normotensive controls were included in the study. ABPM was performed in all participants over a 24-h period. The clinical severity of the disease was determined according to current indexes. Results: The prevalence of MH among subjects with psoriasis vulgaris was 31.8% and increased compared to control subjects (p<0.01). Predictors of MH in patients with psoriasis vulgaris were detected as male sex, smoking, obesity-related anthropometric measures, and disease activity. Male sex, waist circumference, and diffuse psoriatic involvement were detected as independent predictors of MH. Conclusions: MH is prevalent in patients with psoriasis vulgaris. Assessment with ABPM and close follow-up for development of hypertension is reasonable.
Open Access
The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population
(2019-01-01T00:00:00Z) ONSUN, NAHİDE; Pirmit, Serpil; Ozkaya, Dilek; Çelik, Şirin; Rezvani, Aylin; CENGİZ, Fatma Pelin; Kekik, Cigdem; ONSUN, NAHIDE; REZVANİ, AYLİN; CENGİZ, FATMA PELIN
Background. Psoriasis is a multifactorial immune-mediated infammatory disease triggered by both genetic and environmental factors. Te strong association between psoriasis and HLA-C∗06 allele has been demonstrated in various races. Te HLAC∗12 allele is closely related to the HLA-C∗06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C∗12 and psoriasis in the Turkish population. Te present study aims to determine this relationship. Methods. Tis case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C∗06, HLA-C∗12, and HLA-C∗04 alleles were most commonly observed in psoriasis patients. HLA-C∗06 and HLA-C∗12 were signifcantly more frequent in the psoriasis group. HLA-C∗06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C∗12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C∗12 allele. Conclusions. HLA-C∗12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.
Open Access
Demographic characteristics, aetiology, and assessment of treatment options in leukocytoclastic vasculitis.
(2017-04-01) CAKıTER, AU; Kucuk, OS; OZKAYA, DB; TOPUKÇU, B; ONSUN, NAHİDE; SU KÜÇÜK, ÖZLEM; BIYIK ÖZKAYA, DİLEK; ONSUN, NAHIDE
Introduction: Vasculitides are a heterogeneous group of diseases characterized by inflammation of the blood vessel walls. Etiological factors include infections, drugs, connective tissue diseases, and malignancies. Aim: To examine the demographic characteristics, etiological factors, and treatment options in 75 patients with leukocytoclastic vasculitis. Material and methods: The study included 75 patients diagnosed with leukocytoclastic vasculitis at our clinic. The patients’ medical records were reviewed to determine their age, sex, presence of systemic symptoms, possible etiological factors, laboratory results, types of cutaneous lesions, locations of the lesions, treatment options, and disease course. Results: There were 43 women and 32 men. Cutaneous lesions affected only the lower limbs in 60 of the 75 patients (80%) and usually presented as palpable purpura (64%, n = 48). Arthralgia (26.7%, n = 20) was the most frequent extracutaneous symptom. Of the patients with secondary vasculitis, the most common causes were infections and drugs. The mean age of the patients with Henoch-Schönlein purpura was 26.8 years. There was no significant association between age and renal, gastrointestinal, or joint involvement. Conclusions: The most common form of vasculitis in our study was cutaneous leukocytoclastic vasculitis. In most of the patients it appeared to be idiopathic. Among drugs, antibiotics were the most common etiological factor. In 4 patients, the cutaneous leukocytoclastic vasculitis behaved like the paraneoplastic syndrome.
Open Access
Frequency and risk factors for secondary malignancies in patients with mycosis fungoides
(2016-08-01) EMIROGLU, NAZAN; CENGIZ, F. P.; BAHALI, A. Gulsel; Su, O.; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), has an incidence of 6.4 per million people [1]. Patients with CTCL have an increased risk of the development of secondary malignancies, particularly lymphomas [2,3]. We conducted a 20-year population-based cohort study to assess the risk factors of secondary cancers in MF patients from our center.
Open Access
Acne located on the trunk, whey protein supplementation: Is there any association?
(2017-03-05) CENGIZ, FATMA PELİN; Cevirgen, Cemil; EMIROGLU, NAZAN; Gulsel, Bahali; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; BAHALI, ANIL GÜLSEL; ONSUN, NAHIDE
Whey protein is a source of protein that was isolated from milk. Whey proteins are composed of higher levels of essential amino acids. The role of diet in acne etiology has been investigated for several years. It was established that milk and milk products can trigger acneiform lesions, and recent evidence supports the role of whey protein supplements in acne. Herein, we report 6 healthy male adolescent patients developing acne located only to the trunk after the consumption of whey protein supplements for faster bodybuilding. This is the first observation which specified the location of acneiform lesions among bodybuilders. In our opinion, a trendy and common health problem is beginning among adolescents in the gyms.
Open Access
Non-healing ulcer on the foot: early onset unilateral Mali-type acroangiodermatitis.
(2013-01-01) OZKAYA, DB; Su, O; ONSUN, NAHİDE; ULUSAL, H; DEMIRKESEN, C; BIYIK ÖZKAYA, DİLEK; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Acroangiodermatitis (pseudo-Kaposi's sarcoma, AAD) is a benign vascular dermatosis that resembles Kaposi's sarcoma clinically and histopathologically (1). Four types have been defined: the Stewart-Bluefarb type accompanying chronic arteriovenous malformations, the Mali type accompanying stasis dermatitis, a type accompanying the first gestation, and a type accompanying arteriovenous shunts in patients with chronic kidney failure (3). Although AAD development is associated with chronic venous failure, less frequently AAD can develop as a complication of extremity paralysis, hemodialysis, post-traumatic arteriovenous fistula, amputated extremities, and vascular malformations (e.g., Klippel-Trénaunay syndrome). Pseudo-Kaposi's sarcoma can be histopathologically and clinically confused with malignant diseases such as Kaposi's sarcoma (1, 4). A 22-year-old male was referred to our outpatient clinic with a complaint of a non-healing wound on the distal phalanx of the left first toe. The patient was referred to various centers for 2 years and stated that he had received infection treatments but that his complaints did not disappear. An AAD diagnosis was established for the patient based on clinical and histopathologic evidence. Because he had early-onset disease and it was unilateral, the diagnosis was delayed. In addition, due to the rare occurrence of the disease, we histopathologically diagnosed this patient as having acroangiodermatitis.
Open Access
Effectiveness of the Capparis spinosa Treatment in Vitiligo
(2018-02-01T00:00:00Z) EMİROĞLU, NAZAN; CENGİZ, FATMA PELİN; BAHALI, ANIL GÜLSEL; BIYIK ÖZKAYA, DİLEK; SU KÜÇÜK, ÖZLEM SU; ONSUN, NAHİDE; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN; BAHALI, ANIL GÜLSEL; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Open Access
Comparing Mean Platelet Volume Values in Patients with Recurrent Aphthous Stomatitis and Patients with Behcet-s Disease
(2018-07-01T00:00:00Z) Biyik Ozkaya, Dilek; KÜÇÜK, ÖZLEM SU; ONSUN, NAHİDE; BIYIK ÖZKAYA, DİLEK; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
Objective: Platelets play an important role in the pathogenesis of disorders associated with the local or systemic inflammation. Mean platelet volume (MPV) is a marker for platelet activation, and larger platelets are more activated. In this study, we aimed to investigate MPV values in patients with Behcet-s disease, patients with recurrent aphthous stomatitis, and controls.
Open Access
Atrial conduction abnormalities in patients with psoriasis vulgaris.
(2015-01-01) TASAL, A; GUVENC, TS; KUL, S; BACAKSIZ, AHMET; ERDOGAN, EZGİ BAŞAK; SONMEZ, O; SEVGILI, E; Dizman, DİDEM; ONSUN, NAHİDE; BACAKSIZ, AHMET; DİZMAN, DİDEM; ONSUN, NAHIDE; KAHRAMAN AY, NURAY
Background: Psoriasis vulgaris is one of the most common chronic inflammatory skin disorders. Patients with psoriasis are at risk of developing atrial fibrillation (AF). The electromechanical delay (EMD) is the time interval from the onset of the P wave on surface electrocardiography (ECG) to the beginning of the A wave. Prolonged atrial EMD is an independent risk factor for the development of AF. Aim: This study investigated the intra- and interatrial EMD in patients with psoriasis. Methods: This study included 85 adults with psoriasis vulgaris (Group 1) and 46 age- and sex-matched healthy individuals (Group 2). ECGs were obtained from all subjects, and atrial EMD variables were calculated. Results are reported as means ± standard deviations and percentages. Continuous variables were analysed using Student’s t-test. A p-value < 0.05 was considered statistically significant. Results: Interatrial electromechanical delay (IA-EMD) and intra-left atrial electromechanical delay (ILA-EMD) were significantly longer in the psoriasis group compared with controls. A correlation analysis between psoriasis severity (PASI score) and the atrial conduction parameters revealed a significant positive correlation between PASI and IA-EMD (r = 0.261, p < 0.001). In addition, there was a positive correlation between high-sensitivity C-reactive protein (hsCRP) and IA-EMD (p = 0.022). Conclusions: The atrial conduction time was longer in patients with psoriasis vulgaris and it correlated with the severity of disease and hsCRP. Since the association between delayed conduction and AF is known, the measurement of intra-atrial conduction times could be a practical tool to estimate the AF risk in these patients.
Open Access
Disseminated scar sarcoidosis may predict pulmonary involvement in sarcoidosis.
(2013-09-01) Su, O; ONSUN, NAHİDE; TOPUKÇU, B; OZÇELIK, HK; CAKıTER, AU; BÜYÜKPıNARBAŞıLı, NUR; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE; BÜYÜKPINARBAŞILI, NUR
Sarcoidosis is a chronic, inflammatory, multi-organ disease of unknown origin that is characterized by non-caseating granuloma formation in affected organs. Cutaneous involvement is reported in 25% of patients with sarcoidosis. Scar sarcoidosis is rare but is clinically specific for skin sarcoidosis. Systemic involvement is seen in most patients with scar sarcoidosis. We present a case of scar sarcoidosis in a 30-year-old male that developed infiltrated nodules on old scars, including on his penile shaft, which is rare, and that also had pulmonary involvement. Scar sarcoidosis should be considered in the differential diagnosis of changes in all scar areas and should be investigated for systemic involvement.