Person: ULUGANYAN, MAHMUT
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Publication Open Access Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge.(2019-01-01T00:00:00Z) Bakshaliyev, N; Karacop, E; Cosansu, K; Huyut, MA; Turna, F; Enhos, A; Nadir, A; Ozdemir, R; Uluganyan, MAHMUT; ENHOŞ, ASIM; KARAÇÖP, ERDEM; BAKHSALIYEV, NIJAD; NADİR, AYDIN; ÖZDEMİR, RAMAZAN; ULUGANYAN, MAHMUTBackground: Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal segment of the brigde. Objective: To evaluate the relationhip between MHR and the presence of MB. Methods: We consecutively scanned patients referred for coronary angiography between January 2013- December 2016, and a total of 160 patients who had a MB and normal coronary artery were enrolled in the study. The patients’ angiographic, demographic and clinic characteristics of the patients were reviewed from medical records. Monocytes and HDL-cholesterols were measured via complete blood count. MHR was calculated as the ratio of the absolute monocyte count to the HDL-cholesterol value. MHR values were divided into three tertiles as follows: lower (8.25 ± 1.61), moderate (13.11 ± 1.46), and higher (21.21 ± 4.30) tertile. A p-value of < 0.05 was considered significant. Results: MHR was significantly higher in the MB group compared to the control group with normal coronary arteries. We found the frequency of MB (p = 0.002) to increase as the MHR tertiles rose. The Monocyte-HDL ratio with a cut-point of 13.35 had 59% sensitivity and 65.0% specificity (ROC area under curve: 0.687, 95% CI: 0.606-0.769, p < 0.001) in accurately predicting a MB diagnosis. In the multivariate analysis, MHR (p = 0.013) was found to be a significant independent predictor of the presence of MB, after adjusting for other risk factors. Conclusion: The present study revealed a significant correlation between MHR and MB.Publication Open Access The Impact of Admission Serum Creatinine Derived Estimated Glomerular Filtration Rate on Major Adverse Cardiac Events in ST Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention(2016-04-01) ULUGANYAN, MAHMUT; KARACA, GÜRKAN; ULUTAŞ, TÜRKER KEMAL; EKMEKÇİ, AHMET; BAKSHALİYEV, NİJAD; MURAT, AHMET; KÖROĞLU, BAYRAM; UYAREL, HÜSEYİN; EREN, MEHMET; ULUGANYAN, MAHMUT; BAKHSALIYEV, NIJADBackground: The impact of Cockroft-Gault (C-G) derived estimated glomerular filtration rate (eGFR) on mortality and major adverse cardiac events (MACEs) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) was assessed. Methods: A total of 884 patients were classified into four categories according to admission creatine derived eGFR: < 60, 60 - < 90, 90 - < 120, and ≥ 120 mL/min/1.73 m(2). Results: In-hospital and long-term MACEs were significantly higher in eGFR < 60 mL/min/1.73 m(2) subgroup (P < 0.001 and P = 0.028). Multivariate analysis demonstrated 7.78-fold (95% CI: 0.91 - 66.8) higher mortality risk in eGFR < 60 mL/min/1.73 m(2) subgroup. Conclusion: As an easily applicable bedside method, C-G derived eGFR could be important for prediction of in-hospital and long-term mortality and MACE in STEMI patients undergoing primary PCI.Publication Open Access Combination of hemoglobin and left ventricular ejection fraction as a new predictor of contrast induced nephropathy in patients with non-ST elevation myocardial infarction(2014-06-12) Ugur, Murat; Uluganyan, MAHMUT; Ekmekci, Ahmet; Bozbay, Mehmet; Karaca, Gurkan; Cicek, Gokhan; Koroglu, Bayram; Tusun, Eyup; Murat, Ahmet; Turan, Burak; Uyarel, Huseyin; Orhan, Ahmet Lutfi; Eren, Mehmet; ULUGANYAN, MAHMUTBackground: Hemoglobin concentration (Hb) and left ventricular ejection fraction (EF) are known predictors of contrast induced nephropathy (CIN). We hypothesized that combination of Hb concentration and left ventricular EF is superior to either variable alone in predicting contrast induced nephropathy in patients with acute coronary syndrome (ACS). Material and methods: Consecutive patients with ACS were prospectively enrolled. Patients considered for invasive strategy were included. Baseline creatinine levels were detected on admission and 24, 48 and 72 hours after coronary intervention. 25% or 0,5 umol/L increase in creatinine level was considered as CIN. Results: 268 patients with ACS (mean age 58±11 years, 77% male) were enrolled. Contrast induced nephropathy was observed in 26 (9.7%) of patients. Baseline creatinine concentration, left ventricular EF, and Hemoglobin was significantly different between two groups. Contrast volume to estimated glomerular filtration rate ratio (OR: 1.310, 95% CI: 1.077-1.593, p=0.007) and the combination of Hb and left ventricular EF (OR: 0.996, 95% CI: 0.994-0.998, p=0.001) were found to be independent predictors for CIN. Hb × LVEF ≤690 had 85% sensitivity and 57% specificity to predict CIN (area under curve: 0.724, 95% CI: 0.625-0.824, p<0.001). In addition, Hb × LVEF ≤690 had a negative predictive value of 97% in our analysis Conclusions: The combination of Hb and left ventricular EF is better than either variable alone at predicting CIN in patients with ACS that undergone percutaneous coronary intervention. The prediction was independent of baseline renal function and volume of contrast agent.Publication Open Access ST-Segment Elevation of Right Precordial Lead (V4R) Is Associated with Multivessel Disease and Increased In-Hospital Mortality in Acute Anterior Myocardial Infarction Patients(2015-07-01) Tusun, Eyyup; Uluganyan, MAHMUT; Ugur, Murat; Karaca, Gurkan; Osman, Faizel; Koroglu, Bayram; Murat, Ahmet; Ekmekci, Ahmet; Uyarel, Huseyin; Sahin, Osman; Eren, Mehmet; Bolca, Osman; ULUGANYAN, MAHMUTBackground: ST segment elevation of chest lead V4 R is associated with worse prognosis in acute inferior ST-elevation myocardial infarction (STEMI). This study tried to determine the relationship between ST elevation in the right precordial lead V4 R and acute anterior STEMI. Methods: Prospective study of 144 consecutive anterior STEMI patients: all had 15-lead ECG recordings (12 conventional leads and V3 R-V5 R) obtained. Patients were classified into two groups on the basis of presence (Group I, 50 patients) or absence (Group II, 94 patients) of ST-segment elevation ≥0.5 mm in lead V4 R. Results: Multivessel involvement was significantly higher in Group I compared with Group II (54% and 23% respectively, P < 0.001). Major adverse cardiac events and in-hospital mortality was also significantly higher for those in Group I (P < 0.02 for both). A significant correlation was found between in-hospital mortality and those in Group I (P = 0.03, OR: 6.27, CI: 1.22-32.3). There was an independent relationship between in-hospital mortality and V4 R-ST elevation (P = 0.03, OR: 11.64, CI: 1.3-27.4). Conclusion: ST segment elevation in chest lead V4 R is associated with multivessel disease and increased in-hospital mortality in patients with anterior STEMI that had undergone primary percutaneous coronary intervention to the left anterior descending artery.Publication Open Access The effect of 5-day course of hydroxychloroquine and azithromycin combination on QT interval in non-ICU COVID19(+) patients(2020-09-01T00:00:00Z) Bakhshaliyev, Nijad; ULUGANYAN, Mahmut; ENHOŞ, Asim; KARAÇÖP, ERDEM; ÖZDEMİR, Ramazan; BAKHSALIYEV, NIJAD; ULUGANYAN, MAHMUT; ENHOŞ, ASIM; KARAÇÖP, ERDEM; ÖZDEMİR, RAMAZANBackground: The combination of Hydroxychloroquine (HCQ) and azithromycin showed effectiveness as a treat-ment for COVID-19 and is being used widely all around the world. Despite that those drugs are known to cause prolonged QT interval individually there is no study assessing the impact of this combination on electrocardiography (ECG). This study aimed to assess the impact of a 5-day course of HCQ and azithromycin combination on ECG in non-ICU COVID19(+) patients.Publication Metadata only A Brief Reconnoitre about Effects of MMP9 on Aortic Dissection(2021-11-01T00:00:00Z) Uluganyan, Mahmut; ULUGANYAN, MAHMUTPublication Open Access Impact of admission blood glucose levels on prognosis of elderly patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention(2013-01-01) Ekmekci, Ahmet; Uluganyan, MAHMUT; Tufan, Fatif; Uyarel, Huseyin; Karaca, Gurkan; Kul, Seref; Gungor, Baris; Ertas, Gokhan; Erer, Betul; Sayar, Nurten; Gul, Mehmet; Eren, Mehmet; ULUGANYAN, MAHMUTObjective: Admission hyperglycemia in acute myocardial infarction (MI) is related with increased in-hospital and long term mortality and major cardiac adverse events. We aimed to investigate how admission hyperglycemia affects the short and long term outcomes in elderly patients (> 65 years) after primary percutaneous coronary intervention for ST elevation myocardial infarction. Methods: We retrospectively analyzed 677 consecutive elderly patients (mean age 72.2 ± 5.4). Patients were divided into two groups according to admission blood glucose levels. Group 1: low glucose group (LLG), glucose < 168 mg/dL; and Group 2: high glucose group (HGG), glucose > 168 mg/dL. Results: In-hospital, long term mortality and in-hospital major adverse cardiac events were higher in the high admission blood glucose group (P < 0.001). Multivariate regression analysis showed: Killip > 1, post-thrombolysis in MI < 3 and admission blood glucose levels were independent predictors of in-hospital adverse cardiac events (P < 0.001). Conclusions: Admission hyperglycemia in elderly patients presented with ST elevation myocardial infarction is an independent predictor of in-hospital major adverse cardiac events and is associated with in-hospital and long term mortality.Publication Metadata only Admission serum potassium level is associated with in-hospital and long-term mortality in ST-elevation myocardial infarction(2016-01-01) Uluganyan, MAHMUT; Ekmekci, Ahmet; Murat, Ahmet; Avsar, Sahin; Ulutas, Turker Kemal; Uyarel, Huseyin; Bozbay, Mehmet; Cicek, Gokhan; Karaca, Gurkan; Eren, Mehmet; ULUGANYAN, MAHMUTObjective: Current guidelines recommend a serum potassium (sK) level of 4.0-5.0 mmol/L in acute myocardial infarction patients. Recent trials have demonstrated an increased mortality rate with an sK level of >4.5 mmol/L. The aim of this study was to figure out the relation between admission sK level and in-hospital and long-term mortality and ventricular arrhythmias.Publication Open Access The Treatment Role of Anti-aggregants and Anti-coagulants in Radial Artery Occlusion after Transradial Coronary Angiography(2023-07-01) Nadir A.; Uluganyan M.; NADİR, AYDIN; ULUGANYAN, MAHMUTObjective: The transradial approach (TRA) has been widely used for coronary procedures. The rate of complications such as bleeding, hematoma and pseudoaneurysm is reduced with TRA. The purpose of this study is to search the treatment role of anti-aggregants and low molecular weight heparins (LMWH) in situation of radial artery occlusion (RAO). Methods: A total of 239 patients (140 men, 58.6%) were included. Of the patients 159 (66.5%) were elective, and 80 (33.5%) had acute coronary syndrome. When RAO was detected, patients were treated with 2 weeks of LMWH. Results: In 23 (9.6%) of 239 patients, RAO was observed. From the 23 patients with RAO, 12 (52.8%) were using anti-aggregants, and the remaining 11 (47.8%) did not use. In terms of RAO, a statistically significant difference was observed between antiaggregant users and non-users (p<0.001). In the group using antiaggregants and LMWH a statistically significant improvement was observed in the radial flow compared with the group treated withLMWH alone (p<0.001). Conclusion: In the present study, we showed that the addition of anti-aggregants to anti-coagulants decreased RAO rate, declined the symptoms of RAO, also potentiated the effects of anti-coagulants and resulted in better recanalization rate of RAO