Person: ŞAHAN, EBRU
Search Results
Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment
2019-01-01, ÖZTÜRK, AHMET, Şahan, Ebru, MIRÇIK, ALİ BARLAS, DEVECİ, ERDEM, YILMAZ, ONUR, KIRPINAR, İSMET, ÖZTÜRK, AHMET, ŞAHAN, EBRU, MIRÇIK, ALİ BARLAS, DEVECİ, ERDEM, YILMAZ, ONUR, KIRPINAR, İSMET
Objective: Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods: Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion: MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion: Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression.
Oxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?
2019-01-01, DEVECİ, ERDEM, Kocacenk, Tuba, ŞAHAN, EBRU, YILMAZ, ONUR, ÖZTÜRK, AHMET, KIRPINAR, İSMET, DEVECİ, ERDEM, ŞAHAN, EBRU, YILMAZ, ONUR, ÖZTÜRK, AHMET, KIRPINAR, İSMET
Sialorrhoea associated with sertraline use
2019-09-10T00:00:00Z, ŞAHAN, EBRU, KILIÇARSLAN, TEZER, KIRPINAR, İSMET, ŞAHAN, EBRU, KILIÇARSLAN, TEZER, KIRPINAR, İSMET
Introduction: Sialorrhoea, which has been defined as excessive amount of saliva in the mouth, can be a debilitating symptom. Psychoactive drugs may cause an increase or decrease in saliva secretion. Antidepressant drugs, especially tricyclic antidepressants and less often serotonin reuptake inhibitors, are often associated with a decrease in salivation and the complaint of dry mouth. Case presentation: A 46-year-old male patient with complaints of being depressed, lack of motivation, irritability and difficulty in falling asleep was started on sertraline treatment and had trouble with sialorrhoea after the dose increase, without other causes of hypersalivation. Discussion: We could not find report of any case with antidepressant-associated sialorrhoea in the literature. Future cases may support a relationship between sertraline and sialorrhoea.
Impulsivity and impulse control disorders in pregnancy
2018-01-01, Eroglu, Meliha Zengin, Sahan, EBRU, ŞAHAN, EBRU
OBJECTIVE: We investigate the relationship between impulsivity and impulse control disorders (ICDs) in pregnancy. We claim that women with unplanned pregnancies are more impulsive and have a higher frequency of ICDs.
Hypomanic Episode in CADASIL Syndrome
2017-03-01T00:00:00Z, Eroglu, Meliha Zengin, Sahan, EBRU, ŞAHAN, EBRU
MODAFINIL INTOXICATION INDUCED PERSISTENT PSYCHOSIS: CASE REPORT
2019-01-01T00:00:00Z, ŞAHAN, EBRU, BÖLÜKBAŞI, Özgür, ŞAHAN, EBRU, BÖLÜKBAŞI, ÖZGÜR
Oianzapine and tardive dyskinesia: a case report
2017-02-01T00:00:00Z, Sahan, EBRU, zengin eroğlu, Meliha, ŞAHAN, EBRU
Tardive dyskinesia is a serious and common motor side-effect of treatment with especially traditional neuroleptics with an unknown pathophysiological basis. The essential features of neuroleptic-induced tardive dyskinesia (TD) are abnormal, involuntary movements of the tongue, jaw, trunk or extremities that emerges in a patient predisposed to antipsychotic medication. Although the exact pathogenesis of TD is unclear, there is some evidence that dopamine supersensitivity in the nigro-striatal pathway due to the antipsychotics could contribute to these dyskinetic movements. Atypical antipsychotics have less risk in terms of tardive dyskinesia compared to traditional neuroleptics however there is stil probability of late adverse effects. Although it has been suggested that olanzapine can improve tardive dyskinesia in some patients, few reported cases have shown that the prolonged use of olanzapine can instead be associated with tardive dyskinesia/dystonia. Here we report a case who experienced tardive dyskinesia after 12 years of treatment with olanzapine and its treatment with clozapine.
Clozapine Withdrawal Catatonia Refractory to ECT: A Case Report
2012-09-01T00:00:00Z, CERİT, CEM, tüzün, Basak, akpınar, Esma, Sahan, EBRU, ŞAHAN, EBRU
Clozapine withdrawal catatonia refractory to ECT: a case report
Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study
2022-10-01T00:00:00Z, Cakir, Ahsen, Bozali, Kubra, Celikten, Mert, Guler, Eray Metin, Sahan, Ebru, DURDU, BÜLENT, SÜMBÜL, BİLGE, KOÇYİĞİT, ABDÜRRAHİM, ŞAHAN, EBRU, DURDU, BÜLENT, SÜMBÜL, BİLGE, KOÇYİĞİT, ABDÜRRAHİM
Since most infectious diseases can develop into sepsis, it is still a major medical problem. Some in-vivo studies showed promising properties of fluoxetine in the treatment of infections. This study aims the antimicrobial effect of fluoxetine on the inflammatory process used in the treatment of sepsis-modeled rats. Besides, to investigate the efficacy of fluoxetine on modifying the antibiotic effect of imipenem in the inflammatory response. An experimental sepsis model was divided into negative control, positive control, fluoxetine 5 mg/kg, imipenem 60 mg/kg, and combined (fluoxetine; imipenem). Procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), lactate, myeloperoxidase activity (MPO), the inflammation markers interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1) levels were measured by enzyme-linked immunosorbent assay method. Oxidative stress markers, total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), and native thiol (NT) were measured using photometric methods. Oxidative stress index (OSI) was calculated according to TAS and TOS levels. The statistical analysis was performed by Statistical Package for Social Sciences version 22.0. After treatment with fluoxetine, imipenem, and combined groups, IL-1 beta, IL-6, TNF-alpha, MPO activity, MCP-1, hs-CRP, PCT, lactate, and the oxidative stress markers OSI, and disulfide levels were decreased (p < 0.05). The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti-inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model.
Anxiety, Depression, and General Psychological Distress in Patients with Coronary Slow Flow
2015-10-01T00:00:00Z, Özcan, Kazim Serhan, karataş, Mehmet Baran, Sahan, EBRU, İpek, Gokturk, Çanga, Yigit, Güngör, Baris, Onuk, Tolga, Çakıllı, Yasin, Arugaslan, Emre, Bolca, Osman, ŞAHAN, EBRU
Background: The relationship between psychiatric illness and heart disease has been frequently discussed in the literature. The aim of the present study was to investigate the relationship between anxiety, depression and overall psychological distress, and coronary slow flow (CSF).