Person: ŞAHAN, EBRU
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Publication Metadata only Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment(2019-01-01) ÖZTÜRK, AHMET; Şahan, Ebru; MIRÇIK, ALİ BARLAS; DEVECİ, ERDEM; YILMAZ, ONUR; KIRPINAR, İSMET; ÖZTÜRK, AHMET; ŞAHAN, EBRU; MIRÇIK, ALİ BARLAS; DEVECİ, ERDEM; YILMAZ, ONUR; KIRPINAR, İSMETObjective: Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods: Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion: MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion: Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression.Publication Metadata only Hypomanic Episode in CADASIL Syndrome(2017-03-01T00:00:00Z) Eroglu, Meliha Zengin; Sahan, EBRU; ŞAHAN, EBRUPublication Metadata only Clozapine Withdrawal Catatonia Refractory to ECT: A Case Report(2012-09-01T00:00:00Z) CERİT, CEM; tüzün, Basak; akpınar, Esma; Sahan, EBRU; ŞAHAN, EBRUClozapine withdrawal catatonia refractory to ECT: a case reportPublication Metadata only Oxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?(2019-01-01) DEVECİ, ERDEM; Kocacenk, Tuba; ŞAHAN, EBRU; YILMAZ, ONUR; ÖZTÜRK, AHMET; KIRPINAR, İSMET; DEVECİ, ERDEM; ŞAHAN, EBRU; YILMAZ, ONUR; ÖZTÜRK, AHMET; KIRPINAR, İSMETPublication Metadata only MODAFINIL INTOXICATION INDUCED PERSISTENT PSYCHOSIS: CASE REPORT(2019-01-01T00:00:00Z) ŞAHAN, EBRU; BÖLÜKBAŞI, Özgür; ŞAHAN, EBRU; BÖLÜKBAŞI, ÖZGÜRPublication Metadata only Sialorrhoea associated with sertraline use(2019-09-10T00:00:00Z) ŞAHAN, EBRU; KILIÇARSLAN, TEZER; KIRPINAR, İSMET; ŞAHAN, EBRU; KILIÇARSLAN, TEZER; KIRPINAR, İSMETIntroduction: Sialorrhoea, which has been defined as excessive amount of saliva in the mouth, can be a debilitating symptom. Psychoactive drugs may cause an increase or decrease in saliva secretion. Antidepressant drugs, especially tricyclic antidepressants and less often serotonin reuptake inhibitors, are often associated with a decrease in salivation and the complaint of dry mouth. Case presentation: A 46-year-old male patient with complaints of being depressed, lack of motivation, irritability and difficulty in falling asleep was started on sertraline treatment and had trouble with sialorrhoea after the dose increase, without other causes of hypersalivation. Discussion: We could not find report of any case with antidepressant-associated sialorrhoea in the literature. Future cases may support a relationship between sertraline and sialorrhoea.Publication Metadata only Oianzapine and tardive dyskinesia: a case report(2017-02-01T00:00:00Z) Sahan, EBRU; zengin eroğlu, Meliha; ŞAHAN, EBRUTardive dyskinesia is a serious and common motor side-effect of treatment with especially traditional neuroleptics with an unknown pathophysiological basis. The essential features of neuroleptic-induced tardive dyskinesia (TD) are abnormal, involuntary movements of the tongue, jaw, trunk or extremities that emerges in a patient predisposed to antipsychotic medication. Although the exact pathogenesis of TD is unclear, there is some evidence that dopamine supersensitivity in the nigro-striatal pathway due to the antipsychotics could contribute to these dyskinetic movements. Atypical antipsychotics have less risk in terms of tardive dyskinesia compared to traditional neuroleptics however there is stil probability of late adverse effects. Although it has been suggested that olanzapine can improve tardive dyskinesia in some patients, few reported cases have shown that the prolonged use of olanzapine can instead be associated with tardive dyskinesia/dystonia. Here we report a case who experienced tardive dyskinesia after 12 years of treatment with olanzapine and its treatment with clozapine.Publication Metadata only Anxiety, Depression, and General Psychological Distress in Patients with Coronary Slow Flow(2015-10-01T00:00:00Z) Özcan, Kazim Serhan; karataş, Mehmet Baran; Sahan, EBRU; İpek, Gokturk; Çanga, Yigit; Güngör, Baris; Onuk, Tolga; Çakıllı, Yasin; Arugaslan, Emre; Bolca, Osman; ŞAHAN, EBRUBackground: The relationship between psychiatric illness and heart disease has been frequently discussed in the literature. The aim of the present study was to investigate the relationship between anxiety, depression and overall psychological distress, and coronary slow flow (CSF).Publication Open Access Haloperidol-related neutropenia(2019-05-01T00:00:00Z) ŞAHAN, EBRU; ŞAHAN, EBRUPhenothiazines like antipsychotics have been known to cause neutropenia, but this has been reported very rarely with haloperidol. A 20-year-old male patient admitted to emergency service (emergency room) with shortness of breath, chest pain, and anger. He was diagnosed with pneumonia and prescribed moxifloxacin. After 2 days with antibiotic, he readmitted. Left lung pneumothorax was detected, and thorax computerized tomography was requested. However, he opposed and beated one of the hospital officials. The diagnosis of manic episode due to antibiotic moxifloxacin was considered. The tube thoracostomy had to be done, and antibiotic therapy was stopped. Haloperidol 10 mg/day and biperiden 4 mg/day injections were administered because he continued to resist medical interventions. After haloperidol, his leukocyte count decreased. He responded well to filgrastim (Neupogen) and blood transfusions, so a drug-related cause of neutropenia has been suspected. He was switched from haloperidol to quetiapine 300 mg twice a day. His white blood cell count returned to normal levels.Publication Metadata only Impulsivity and impulse control disorders in pregnancy(2018-01-01) Eroglu, Meliha Zengin; Sahan, EBRU; ŞAHAN, EBRUOBJECTIVE: We investigate the relationship between impulsivity and impulse control disorders (ICDs) in pregnancy. We claim that women with unplanned pregnancies are more impulsive and have a higher frequency of ICDs.