Person: ŞAHAN, EBRU
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Publication Open Access State and trait anxiety among medical staff during the first month of COVID-19 pandemic: A sample from Turkey(2021-08-01T00:00:00Z) ŞAHAN, EBRU; TANGİLNTİZ, AİSE; ŞAHAN, EBRU; TANGİLNTİZ, AİSEObjectives During the COVID-19 pandemic, excessive workload, a rapidly changing workplace environment, the danger of carrying the virus and transmitting the disease to their families, relatives and those they live with creates stress for the medical workers. In our study, we aimed to evaluate the state and trait anxiety levels of healthcare professionals who encounter patients with suspected COVID-19 infection and related factors. Method Data were collected from healthcare professionals working with patients diagnosed or suspected with COVID-19 via online self-report questionnaire between 9-19 April 2020. The state (STAI-S) and trait anxiety (STAI-T) scale was used to measure anxiety. Results A total of 291 healthcare professionals, 216 women and 75 men, participated in the study. Women-s state and trait anxiety were significantly higher than men-s. 11 participants without any lifetime psychiatric illness experienced psychiatric symptoms and consulted to a psychiatrist. The state anxiety of those who have children, nurses and those working in branches directly related to the pandemic (Infectious Diseases, Respiratory Diseases, Emergency Medicine, Internal Medicine, Radiology, Anesthesiology and Reanimation) was higher than others. The state anxiety of those who thought they were not protected with personal protective equipment and those who did not stay in their own home was higher than others. Conclusions At the forefront of the fight against COVID-19, there are medical personnel who pay a serious psychological cost. Especially in terms of anxiety, we should pay attention to women, workers with children, nurses and people working in branches that are directly related to pandemics.Publication Metadata only Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment(2019-01-01) ÖZTÜRK, AHMET; Şahan, Ebru; MIRÇIK, ALİ BARLAS; DEVECİ, ERDEM; YILMAZ, ONUR; KIRPINAR, İSMET; ÖZTÜRK, AHMET; ŞAHAN, EBRU; MIRÇIK, ALİ BARLAS; DEVECİ, ERDEM; YILMAZ, ONUR; KIRPINAR, İSMETObjective: Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods: Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion: MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion: Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression.Publication Metadata only Hypomanic Episode in CADASIL Syndrome(2017-03-01T00:00:00Z) Eroglu, Meliha Zengin; Sahan, EBRU; ŞAHAN, EBRUPublication Metadata only Clozapine Withdrawal Catatonia Refractory to ECT: A Case Report(2012-09-01T00:00:00Z) CERİT, CEM; tüzün, Basak; akpınar, Esma; Sahan, EBRU; ŞAHAN, EBRUClozapine withdrawal catatonia refractory to ECT: a case reportPublication Metadata only Oxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?(2019-01-01) DEVECİ, ERDEM; Kocacenk, Tuba; ŞAHAN, EBRU; YILMAZ, ONUR; ÖZTÜRK, AHMET; KIRPINAR, İSMET; DEVECİ, ERDEM; ŞAHAN, EBRU; YILMAZ, ONUR; ÖZTÜRK, AHMET; KIRPINAR, İSMETPublication Metadata only MODAFINIL INTOXICATION INDUCED PERSISTENT PSYCHOSIS: CASE REPORT(2019-01-01T00:00:00Z) ŞAHAN, EBRU; BÖLÜKBAŞI, Özgür; ŞAHAN, EBRU; BÖLÜKBAŞI, ÖZGÜRPublication Metadata only Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study(2022-10-01T00:00:00Z) Cakir, Ahsen; Bozali, Kubra; Celikten, Mert; Guler, Eray Metin; Sahan, Ebru; DURDU, BÜLENT; SÜMBÜL, BİLGE; KOÇYİĞİT, ABDÜRRAHİM; ŞAHAN, EBRU; DURDU, BÜLENT; SÜMBÜL, BİLGE; KOÇYİĞİT, ABDÜRRAHİMSince most infectious diseases can develop into sepsis, it is still a major medical problem. Some in-vivo studies showed promising properties of fluoxetine in the treatment of infections. This study aims the antimicrobial effect of fluoxetine on the inflammatory process used in the treatment of sepsis-modeled rats. Besides, to investigate the efficacy of fluoxetine on modifying the antibiotic effect of imipenem in the inflammatory response. An experimental sepsis model was divided into negative control, positive control, fluoxetine 5 mg/kg, imipenem 60 mg/kg, and combined (fluoxetine; imipenem). Procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), lactate, myeloperoxidase activity (MPO), the inflammation markers interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1) levels were measured by enzyme-linked immunosorbent assay method. Oxidative stress markers, total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), and native thiol (NT) were measured using photometric methods. Oxidative stress index (OSI) was calculated according to TAS and TOS levels. The statistical analysis was performed by Statistical Package for Social Sciences version 22.0. After treatment with fluoxetine, imipenem, and combined groups, IL-1 beta, IL-6, TNF-alpha, MPO activity, MCP-1, hs-CRP, PCT, lactate, and the oxidative stress markers OSI, and disulfide levels were decreased (p < 0.05). The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti-inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model.Publication Metadata only Sialorrhoea associated with sertraline use(2019-09-10T00:00:00Z) ŞAHAN, EBRU; KILIÇARSLAN, TEZER; KIRPINAR, İSMET; ŞAHAN, EBRU; KILIÇARSLAN, TEZER; KIRPINAR, İSMETIntroduction: Sialorrhoea, which has been defined as excessive amount of saliva in the mouth, can be a debilitating symptom. Psychoactive drugs may cause an increase or decrease in saliva secretion. Antidepressant drugs, especially tricyclic antidepressants and less often serotonin reuptake inhibitors, are often associated with a decrease in salivation and the complaint of dry mouth. Case presentation: A 46-year-old male patient with complaints of being depressed, lack of motivation, irritability and difficulty in falling asleep was started on sertraline treatment and had trouble with sialorrhoea after the dose increase, without other causes of hypersalivation. Discussion: We could not find report of any case with antidepressant-associated sialorrhoea in the literature. Future cases may support a relationship between sertraline and sialorrhoea.Publication Metadata only Oianzapine and tardive dyskinesia: a case report(2017-02-01T00:00:00Z) Sahan, EBRU; zengin eroğlu, Meliha; ŞAHAN, EBRUTardive dyskinesia is a serious and common motor side-effect of treatment with especially traditional neuroleptics with an unknown pathophysiological basis. The essential features of neuroleptic-induced tardive dyskinesia (TD) are abnormal, involuntary movements of the tongue, jaw, trunk or extremities that emerges in a patient predisposed to antipsychotic medication. Although the exact pathogenesis of TD is unclear, there is some evidence that dopamine supersensitivity in the nigro-striatal pathway due to the antipsychotics could contribute to these dyskinetic movements. Atypical antipsychotics have less risk in terms of tardive dyskinesia compared to traditional neuroleptics however there is stil probability of late adverse effects. Although it has been suggested that olanzapine can improve tardive dyskinesia in some patients, few reported cases have shown that the prolonged use of olanzapine can instead be associated with tardive dyskinesia/dystonia. Here we report a case who experienced tardive dyskinesia after 12 years of treatment with olanzapine and its treatment with clozapine.Publication Metadata only Anxiety, Depression, and General Psychological Distress in Patients with Coronary Slow Flow(2015-10-01T00:00:00Z) Özcan, Kazim Serhan; karataş, Mehmet Baran; Sahan, EBRU; İpek, Gokturk; Çanga, Yigit; Güngör, Baris; Onuk, Tolga; Çakıllı, Yasin; Arugaslan, Emre; Bolca, Osman; ŞAHAN, EBRUBackground: The relationship between psychiatric illness and heart disease has been frequently discussed in the literature. The aim of the present study was to investigate the relationship between anxiety, depression and overall psychological distress, and coronary slow flow (CSF).