Person: AKBAŞ, FAHRİ
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Publication Open Access Increased mitochondrial common deletion in platelets from patients with type 2 diabetes is not associated with abnormal platelet activity or mitochondrial function(2018-09-01) Karimova, Ayla; HACIOGLU, Yalçin; Bahtiyar, Nurten; NIYAZOGLU, Mutlu; AKBAŞ, FAHRİ; Yilmaz, Erkan; Ulutin, Turgut; Onaran, Ilhan; AKBAŞ, FAHRİPublication Open Access Expression of cardiac inwardly rectifying potassium channels in pentylenetetrazole kindling model of epilepsy in rats(2018-12-01) MEGA TİBER, PINAR; AKYÜZ, ENES; KARAKAŞ, MERVE; AKBAŞ, FAHRİ; AKYÜZ, ENES; BEKER, MERVE; AKBAŞ, FAHRİClinical and experimental studies show that epilepsy affects cardiac function; however, the underlying molecular mechanism has not been fully elucidated. Inwardly-rectifying potassium (Kir) channels transport K+ ions into excitable cells such as neurons and cardiomyocytes; they control the cell excitability by acting towards the repolarization phase of cardiac action potential. Kir channel expression has been previously shown to vary in epileptic brains, at the same time seizures are known to affect the autonomic nervous system. Kir channel expression in cardiac tissue is a possible mechanism for the explanation of cardiac pathology in epilepsy. We investigate the expression of Kir channels in epileptic cardiac tissue by using pentylenetetrazole (PTZ)-kindling model in rats. Our molecular analyses showed significant decrease in cardiac Kir channel mRNA and protein expression of PTZ-kindled rats. Interestingly, both Kir2.x, which directs I-K1 flux in ventricular tissue and Kir3.x, which is responsible for I-KACh in the atria, were observed to decrease significantly. Kir channel expression also differs between females and males. This is the first study to our knowledge in epileptic cardiac tissue showing the expression of Kir channels. Our results show that Kir channels may play a role in cardiac pathology associated with epilepsy.Publication Open Access Hipotiroidi Tedavisine Deneysel Alternatif Yöntem: Tiroid Dokusunun Kapsüle Edilmesi. Experimental Alternative Method for the Treatment of Hypothyroidism: Capsulation of the Thyroid Tissue.(2018-10-01T00:00:00Z) Yücesan, Emrah; Başoğlu, Harun; Özten Kandaş, Nur; Kanımdan, Ebru; Akbaş, Fahri; Ersoy, Yeliz Emine; Ayşan, Erhan; GÖNCÜ, BEYZA SERVET; AKBAŞ, FAHRİ; ERSOY, YELIZ EMINEObjective: Hypothyroidism is a clinical condition that affects all age groups. Generally, lifelong medication is required for the treatment. Despite treatment, symptoms that are related to hormone insufficiency and side effects due to long-term medication can be seen. As an alternative approach, thyroid tissue transplantation may be useful, because of its potential to elevate the thyroid hormone levels and thus increase daily quality of life for the patients. Our aim in this study was to detect the in vitro optimal microencapsulation conditions for thyroid tissues with a biocompatible polymer to avoid immune rejection following transplantation. Material and Methods: Thyroid tissues were isolated mechanically, and followed-up in two groups; tissue and capsulated tissue culture. In-vitro capsule formation and morphology were screened using brightfield microscopy and T3 and T4 levels were evaluated biochemically throughout 60 days. Results: T3 and T4 levels were screened from collected medium samples at day 3., 9., 12., 15., 30., 45., 60.. In capsuled tissues T3 level was detected higher than the non-capsuled and negative control tissues from day 15. However, T4 level was stable for 60 days.Publication Open Access Evidence that Extreme Dilutions of Paclitaxel and Docetaxel Alter Gene Expression of In Vitro Breast Cancer Cells.(2018-02-01) Şeker, S; Güven, C; Akçakaya, H; Bahtiyar, N; Akbaş, FAHRİ; Onaran, İ; AKBAŞ, FAHRİ