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ŞENOL, HALIL

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HALIL
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ŞENOL
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2016 - 201992020 - 202418
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Synthesis of New Oleanane Triterpenoids Including Fatty Acids Esters and Investigation of Their in vitro Cytotoxic Effects on 3T3 Fibroblast and PC3 Prostate Cancer Cell Lines

2019-12-19, Dağ, Aydan, Topçu, Gülaçtı, Atasoy, Sezen, Aktaş, Asude Sena, Şenol, Halil, ŞENOL, HALIL, DAĞ, AYDAN, ATASOY, SEZEN, TOPÇU, GÜLAÇTI

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Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent

2023-01-01, Şenol H., Özgün Acar Ö., Dağ A., Eken A., Güner H., Aykut Z. G., Topçu G., Şen A., ŞENOL, HALIL, DAĞ, AYDAN, TOPÇU, GÜLAÇTI

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Computer Aided Design and Synthesis of New Ursane Triterpenoids with Nuclear Factor Kappa B Inhibition Effect

2019-12-19, Şenol, Halil, Akdemir, Atilla, Topçu, Gülaçtı, ŞENOL, HALIL, AKDEMİR, ATİLLA, TOPÇU, GÜLAÇTI

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Synthesis and initial evaluation of efficacy of olean-12-en-28-ol, 3 beta-pentacosanoate for the symptomatic treatment of multiple sclerosis

2019-07-01, DAĞ, AYDAN, Sen, A., ŞENOL, HALİL, Kale, E., TOPÇU, GÜLAÇTI, ŞENOL, HALIL, DAĞ, AYDAN, TOPÇU, GÜLAÇTI

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Preclinical studies evaluating the therapeutic efficacy of novel natural compound olean-12-en-28-ol, 3β pentacosanoate for multiple sclerosis

2022-09-26, Şenol H., Özgün-Acar Ö., Dağ A., Eken A., Acar B., Aktaş Pepe N., Güner H., Aykut Z. G., Çevik Kaplan S., Ayaz Güner Ş., et al., ŞENOL, HALIL, DAĞ, AYDAN, TOPÇU, GÜLAÇTI

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Synthesis and rearrangement reactions of 1,4-dihydrospiro[1,4-methanonaphthalene-9,1′-cyclopropane] derivatives

2018-10-04T00:00:00Z, Bayrak, Cetin, Senol, Halil, Sirtbasi, Sedef, Şahin, Ertan, Menzek, Abdullah, ŞENOL, HALIL

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Novel Cholinesterase Inhibitors: Synthesis, Characterization, Molecular Docking, Dynamics and ADME Studies

2023-05-25, Şenol H., ŞENOL, HALIL

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Effect of Lipids in Tissue Factor Activity Isolated From Sheep and Lamb Lung

2017-05-25, TENEKECİGİL, ASLIHAN, ŞENOL, HALİL, ŞENOL, AYŞE MERVE, EMEKLİ, NESRİN, ŞENOL, HALIL

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Synthesis of oleanolic acid hydrazide-hydrazone hybrid derivatives and investigation of their cytotoxic effects on A549 human lung cancer cells

2022-01-01T00:00:00Z, Şenol, Halil, Mercümek, Berre, Şahin, Rabia Büşra, Kapucu, Halil Burak, Hacıosmanoğlu, Ebru, ŞENOL, HALIL, MERCÜMEK, BERRE, HACIOSMANOĞLU, EBRU

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Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line

2018-01-01, Tuncay, Salih, Kocyigit, ABDÜRRAHİM, SEÇEN, Hasan, Ocal, Nuket, Topcu, GÜLAÇTI, Guler, ERAY METİN, ŞENOL, HALIL, GÜLER, ERAY METİN, KOÇYİĞİT, ABDÜRRAHİM, TOPÇU, GÜLAÇTI

Background: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.

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