Person: ŞENOL, HALIL
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Publication Metadata only Synthesis and rearrangement reactions of 1,4-dihydrospiro[1,4-methanonaphthalene-9,1′-cyclopropane] derivatives(2018-10-04T00:00:00Z) Bayrak, Cetin; Senol, Halil; Sirtbasi, Sedef; Şahin, Ertan; Menzek, Abdullah; ŞENOL, HALILPublication Metadata only Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line(2018-01-01) Tuncay, Salih; Kocyigit, ABDÜRRAHİM; SEÇEN, Hasan; Ocal, Nuket; Topcu, GÜLAÇTI; Guler, ERAY METİN; ŞENOL, HALIL; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; TOPÇU, GÜLAÇTIBackground: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.Publication Metadata only Synthesis and initial evaluation of efficacy of olean-12-en-28-ol, 3 beta-pentacosanoate for the symptomatic treatment of multiple sclerosis(2019-07-01) DAĞ, AYDAN; Sen, A.; ŞENOL, HALİL; Kale, E.; TOPÇU, GÜLAÇTI; ŞENOL, HALIL; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Metadata only Synthesis of new fatty acid derivatives of oleanane and ursane triterpenoids and investigation of their in vitro cytotoxic effects on 3T3 fibroblast and PC3 prostate cancer cell lines(2020-09-01T00:00:00Z) Şenol, Halil; Çokuludağ, Kübra; Aktaş, Asude Sena; Atasoy, Sezen; Dağ, Aydan; Topçu, Gülaçtı; ŞENOL, HALIL; ATASOY, SEZEN; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Metadata only Cycloaddition reaction of spiro[2.4]hepta-4,6-dien-1-ylmethanol and PTAD: a new rearrangement(2016-05-19T00:00:00Z) Senol, Halil; Bayrak, Cetin; Menzek, Abdullah; Şahin, Ertan; Karakus, Murat; ŞENOL, HALILReaction of spiro[2.4]hepta-4,6-dien-1-ylmethanol (3) with phenyltriazolinedione (PTAD) gave 4-phenyl-1-[(3aR(S),6S(R))-1a, 2,3a, 6-tetrahydro-1H-cyclopenta[b]cyclopropa[c]furan-6-yl]-1,2,4-triazolidine-3,5-dione (7) via a novel rearrangement. The structure of this rearranged product was determined by spectroscopic methods and by experimentation. Influences of functional groups on the rearrangement and formation of 7 were discussed. (C) 2016 Elsevier Ltd. All rights reserved.Publication Metadata only Investigation of the potential use of Euphorbia latex as an insecticide in biological control against Dendroctonus micans(2021-06-01T00:00:00Z) Gülmez, Özlem; Albayrak İskender, Nurcan; Şenol, Halil; Algur, Ömer Faruk; ŞENOL, HALIL